Work fine

from sqlalchemy import create_engine
from sqlalchemy.orm import sessionmaker
from config import Config
from sqlalchemy.orm import declarative_base
from sqlalchemy import Column,String, Integer, DATETIME

engine = create_engine(Config.SQLALCHEMY_DATABASE_URI, echo=True)

Session = sessionmaker(bind=engine)
session = Session()

Base = declarative_base()

class PPESSOA(Base):

    __tablename__ = 'PPESSOA'

    CODIGO = Column(Integer, primary_key=True)

    CPF = Column(String)
    EMAILPESSOAL = Column(String)
    EMAIL = Column(String)
    NOME = Column(String)
    NOMESOCIAL = Column(String)
    SEXO = Column(String)
    NACIONALIDADE = Column(String)
    ESTADONATAL = Column(String)
    DTNASCIMENTO = Column(DATETIME)
    CARTIDENTIDADE = Column(String)
    ORGEMISSORIDENT = Column(String)
    UFCARTIDENT = Column(String)
    CODMUNICIPIO = Column(String)
    ESTADO = Column(String)

ppessoa:PPESSOA = session.query(PPESSOA).filter(PPESSOA.CODIGO==30861).one()
ppessoa.EMAIL = '[email protected]'

session.commit()
session.close()