bool pulsadoAntes = false;
List<Items> items;


public override void Update(GameTime gameTime)
{
    MouseState mouse = Mouse.GetState();

    if (mouse.LeftButton == ButtonState.Pressed && !pulsadoAntes)
    {
        pulsadoAntes = true;
    }

    if (mouse.LeftButton == ButtonState.Released)
    {
        if (pulsadoAntes)
        {
            for (int i = 0; i < items.Count; i++)
            {
                if (items[i].Rectangulo.Contains(new Point(mouse.X, mouse.Y)))
                {
                    items[i].Accion();
                }
            }
        }
        pulsadoAntes = false;
    }
}