String example = "   (22 ;   325)   ";

String pattern = "\s*(\s*\d+\s*;\s*\d+\s*)\s*";

final String REGEX = "\s*\(*\s*;*\s*]";

//s+//(

//s+;//s+

//s+)//s+`

(

)

;

([0-9])w+

String example = "   (22 ;   325)   ";
String[] items = example.replaceAll("[ ()]", "").split(";");

System.out.println(Arrays.asList(items)); // [22, 325]