Using <a class="StrictlyAutoTagAnchor" title="View all articles about DNA here" href="http://www.scienceandtechnologyresearchnews.com/tag/dna/">DNA</a> from salmon, <a class="StrictlyAutoTagAnchor" title="View all articles about researchers here" href="http://www.scienceandtechnologyresearchnews.com/tag/researchers/">researchers</a> in South <a class="StrictlyAutoTagAnchor" title="View all articles about Korea here" href="http://www.scienceandtechnologyresearchnews.com/tag/korea/">Korea</a> hope to make <a class="StrictlyAutoTagAnchor" title="View all articles about better here" href="http://www.scienceandtechnologyresearchnews.com/tag/better/">better</a> biomedical and other photonic devices based on <a class="StrictlyAutoTagAnchor" title="View all articles about organic here" href="http://www.scienceandtechnologyresearchnews.com/tag/organic/">organic</a> thin films. Often used in cancer treatments and health monitoring, thin films have all the capabilities of <a class="StrictlyAutoTagAnchor" title="View all articles about silicon here" href="http://www.scienceandtechnologyresearchnews.com/tag/silicon/">silicon</a>-based devices with the possible added advantage of being more compatible with living tissue.

A thin film is just what it sounds like, a layer of material only nanometers or micrometers thick that can be used to channel light. If the film is a dielectric—that is, an insulator such as <a class="StrictlyAutoTagAnchor" title="View all articles about glass here" href="http://www.scienceandtechnologyresearchnews.com/tag/glass/">glass</a>—it can be used without worrying that it might conduct electricity.

“<a class="StrictlyAutoTagAnchor" title="View all articles about DNA here" href="http://www.scienceandtechnologyresearchnews.com/tag/dna/">DNA</a> is the most abundant <a class="StrictlyAutoTagAnchor" title="View all articles about organic here" href="http://www.scienceandtechnologyresearchnews.com/tag/organic/">organic</a> material, and it is a transparent dielectric, comparable to <a class="StrictlyAutoTagAnchor" title="View all articles about silica here" href="http://www.scienceandtechnologyresearchnews.com/tag/silica/">silica</a>,” said Kyunghwan “Ken” Oh, of the Photonic Device Physics Laboratory at <a href="https://www.yonsei.ac.kr/en_sc/">Yonsei University</a>, Seoul, South <a class="StrictlyAutoTagAnchor" title="View all articles about Korea here" href="http://www.scienceandtechnologyresearchnews.com/tag/korea/">Korea</a>. In the journal <a href="https://www.osapublishing.org/ome/home.cfm"><em>Optical Materials Express</em></a><em>,</em> from The <a class="StrictlyAutoTagAnchor" title="View all articles about Optical Society here" href="http://www.scienceandtechnologyresearchnews.com/tag/optical-society/">Optical Society</a> (<a href="http://www.osa.org/en-us/home/">OSA</a>), Oh and his colleagues lay out their method for fabricating the thin films in a way that gives them fine control over the material’s optical and thermal properties.

As the basis for the <a class="StrictlyAutoTagAnchor" title="View all articles about silica here" href="http://www.scienceandtechnologyresearchnews.com/tag/silica/">silica</a> <a class="StrictlyAutoTagAnchor" title="View all articles about glass here" href="http://www.scienceandtechnologyresearchnews.com/tag/glass/">glass</a> that <a class="StrictlyAutoTagAnchor" title="View all articles about makes here" href="http://www.scienceandtechnologyresearchnews.com/tag/makes/">makes</a> up optical fibers, <a class="StrictlyAutoTagAnchor" title="View all articles about silicon here" href="http://www.scienceandtechnologyresearchnews.com/tag/silicon/">silicon</a> has long been a dominant material in inorganic photonic devices because it’s readily available and easy to work with from the <a class="StrictlyAutoTagAnchor" title="View all articles about materials here" href="http://www.scienceandtechnologyresearchnews.com/tag/materials/">materials</a> perspective. Oh argues that DNA can play the same role in organic photonic devices because it can be found throughout the living world. It could, for instance, be used to make waveguides similar to silica fibers to carry light within the body. Organic devices should also be easy to manufacture, more flexible than silicon and environmentally friendly.

<strong>‘A sharper arrow’</strong>
One key property of <a class="StrictlyAutoTagAnchor" title="View all articles about materials here" href="http://www.scienceandtechnologyresearchnews.com/tag/materials/">materials</a> used in photonic devices is the refractive index, which determines how light is directed. An optical fiber requires a <a class="StrictlyAutoTagAnchor" title="View all articles about core here" href="http://www.scienceandtechnologyresearchnews.com/tag/core/">core</a> with one index, wrapped in a cladding with a different enough index so that when light hits the interface between <a class="StrictlyAutoTagAnchor" title="View all articles about core here" href="http://www.scienceandtechnologyresearchnews.com/tag/core/">core</a> and cladding, it is forced back into the core instead of leaking away. Makers of optical fiber not only need material with two different refractive indexes, they need to control the magnitude of that difference to get the desired effects.

In fine-tuning a method for using DNA to create thin films that could be used in photonic devices, Oh’s team was able to get a range of refractive indexes four times greater than that available in silicon. With a greater index difference between core and cladding, they can make much thinner optical fibers, as low as 3 microns in diameter, compared to a minimum of 10 in silicon. This allows for a smaller spot size for the light coming out of the fiber, which could be useful in applications that must carefully target light. “If you have a small target, you should have a sharper arrow,” said Oh.

Potential applications could include photodynamic therapy, where a cancer patient is given a <a class="StrictlyAutoTagAnchor" title="View all articles about drug here" href="http://www.scienceandtechnologyresearchnews.com/tag/drug/">drug</a> or other substance that binds to <a class="StrictlyAutoTagAnchor" title="View all articles about cells here" href="http://www.scienceandtechnologyresearchnews.com/tag/cells/">cells</a> in a <a class="StrictlyAutoTagAnchor" title="View all articles about tumor here" href="http://www.scienceandtechnologyresearchnews.com/tag/tumor/">tumor</a> and light activates the <a class="StrictlyAutoTagAnchor" title="View all articles about drug here" href="http://www.scienceandtechnologyresearchnews.com/tag/drug/">drug</a> and destroys the cancer <a class="StrictlyAutoTagAnchor" title="View all articles about cells here" href="http://www.scienceandtechnologyresearchnews.com/tag/cells/">cells</a>, leaving healthy tissue untouched. The films may also be useful in <a class="StrictlyAutoTagAnchor" title="View all articles about optogenetics here" href="http://www.scienceandtechnologyresearchnews.com/tag/optogenetics/">optogenetics</a>, in which light is used to control the activity of specific <a class="StrictlyAutoTagAnchor" title="View all articles about brain here" href="http://www.scienceandtechnologyresearchnews.com/tag/brain/">brain</a> cells, or to make sensors to measure the pressure or oxygen content of blood pressure that could be worn for a long time without causing irritation because they are organic.

<strong>Grappling with inconsistent results</strong>
To make a thin film, which can be used as the basis for photonic devices, <a class="StrictlyAutoTagAnchor" title="View all articles about researchers here" href="http://www.scienceandtechnologyresearchnews.com/tag/researchers/">researchers</a> have to dissolve DNA in water, and then dissolve that mixture into an organic solvent. The liquid is placed on a surface, which spins so the material spreads evenly. The solvent then evaporates to leave the film behind. Because DNA doesn’t readily dissolve, researchers first mix it with a solution of water and cetyltrimethylammonium (CTMA), a soap-like surfactant. The mixture produces a precipitate, which can then be dissolved into the solvent and spin-coated.

While researchers have used this procedure for several years, their results have been inconsistent. “We noticed that, depending on the papers, the refractive index and material properties varied in a wide range, so we were very curious about it,” said Oh. “And we found out the fabrication process was a little bit different from research group to research group.”

<strong>Controlling the process</strong>
Three graduate students in Oh’s lab—Woohyun Jung, Hwiseok Jun and Seongjin Hong—found that by controlling the amount of water and CTMA in their mixture, they could fine-tune the refractive index of the thin film. Testing revealed different mixtures, depending on whether they added droplets of water and DNA into the CTMA solution, or water and CTMA into the DNA bath. Oh describes the strand of DNA as a rope, with sites along it to which the CTMA can bind. “If you drop this rope into a CTMA bath, there are tons of CTMA available, so you can soak the rope with the CTMA,” said Oh. On the other hand, if you drop CTMA onto a large <a class="StrictlyAutoTagAnchor" title="View all articles about batch here" href="http://www.scienceandtechnologyresearchnews.com/tag/batch/">batch</a> of DNA, the “rope” may not get completely wet; that is, there are areas of DNA without CTMA attached.

The more water the mixture contained, the less CTMA there was, and vice versa. By carefully controlling the amount of both, the team could achieve the desired index of refraction. The same approach provided control over the thermal properties of the film, allowing the researchers to control how much the refractive index changed when the film was heated or cooled. That could allow the film to be used as a temperature <a class="StrictlyAutoTagAnchor" title="View all articles about sensor here" href="http://www.scienceandtechnologyresearchnews.com/tag/sensor/">sensor</a>, as changes in the light passing through it would be linked to changes in temperature.

Oh’s lab is also exploring other methods to control the optical properties of DNA. His hope is to develop a set of fundamental principles and processes that will allow manufacturers to <a class="StrictlyAutoTagAnchor" title="View all articles about build here" href="http://www.scienceandtechnologyresearchnews.com/tag/build/">build</a> a wide range of optical devices, including a new generation of <a class="StrictlyAutoTagAnchor" title="View all articles about wearable here" href="http://www.scienceandtechnologyresearchnews.com/tag/wearable/">wearable</a> sensors.

Source : <a href="http://www.osa.org/en-us/about_osa/newsroom/news_releases/2017/dna_the_next_hot_material_in_photonics/"><strong>OSA</strong></a>