Pregabalin's Seizure Concerns and Related Sources

The below demonstrates that Pregabalin has seizure concerns and greater information about it.
Pregabalin has been shown to induce and or increase the risk of seizures at recreational dosages. There is little evidence showing there is a concern at medical dosages (600mg and under). This risk may be increased when mixed with other drugs that lower seizure threshold. Caution is recommended when using doses of higher than 600mg. Reducing various susceptibility factors may also be beneficial in lowering this risk. Susceptibility factors may include things such as low sodium, lack of sleep, and intensive physical activity.

Studies:
Barker-Haliski, M., & White, H. S. (2015). Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863. https://doi.org/10.1101/cshperspect.a022863

Ben-Menachem, E. (2004). Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18. https://doi.org/10.1111/j.0013-9580.2004.455003.x

French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014). Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597. https://doi.org/10.1212/WNL.0000000000000119

Gayatri, N. A., & Livingston, J. H. (2006). Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398. https://doi.org/10.1017/S0012162206000843

Hitchings, A. W. (2016). Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154. https://doi.org/10.1097/FAD.0000000000000016

Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020). Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440. https://doi.org/10.1111/bcp.14348

Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010). Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561. https://doi.org/10.1111/j.1471-4159.2010.06625.x

Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018). Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20. https://doi.org/10.1080/24734306.2018.1458465

Reports:
https://www.reddit.com/r/gabagoodness/comments/111hnbq/had_a_seizure_from_600mg_lyrica_300mg_redose_will/
https://www.reddit.com/r/gabagoodness/comments/z45ypv/i_overdosed_on_pregabalin_and_had_2_really_bad/
https://www.reddit.com/r/gabagoodness/comments/10yos15/how_does_a_seizure_on_pregabalin_looks_like/
https://www.reddit.com/r/gabagoodness/comments/w832w5/what_kind_of_seizures_does_pregabalin_cause/
https://www.reddit.com/r/gabagoodness/comments/115tz8s/pregabalintwitching/
https://www.bluelight.org/community/threads/seizures-from-pregabalin-lyrica.896412/

Altair. (n.d.-a). Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.” Retrieved May 21, 2024, from https://www.erowid.org/experiences/exp.php?ID=69917
Douke, R. (n.d.). Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.” Retrieved May 21, 2024, from https://www.erowid.org/experiences/exp.php?ID=83232
Sean. (n.d.-b). Pregabalin - Erowid Exp - “Stay Away.” Retrieved May 21, 2024, from https://www.erowid.org/experiences/exp.php?ID=67302