list1 = ["a", "b", "c", "d"]
list2 = [1, 2, 3]

[a b c 1 2]
[a b c 1 3]
[a b c 2 3]
[a b d 1 2]
[a b d 1 3]
[a b d 2 3]
[a c d 1 2]
[a c d 1 3]
[a c d 2 3]
[b c d 1 2]
[b c d 1 3]
[b c d 2 3]

import itertools
from itertools import combinations

def combi(arr, r):
    return list(combinations(arr, r))

# Driver Function
if __name__ == "__main__":
    a = ["a", "b", "c", "d"]
    r = 3
    a= combi(arr, r)
    print (a)
    b = [1, 2, 3]
    s =2
    b = combi(brr, s)
    print (b)
    crr = a + b
    print (crr)
    c = combi(crr, 2)
    print (c)
    for i in range(len(c)):
        for j in range(len(c)):
            print c[i][j]
            print 'n'

list1 = ["a", "b", "c", "d"]
list2 = [1, 2, 3]

import itertools

comb1 = itertools.combinations(list1, 3)
comb2 = itertools.combinations(list2, 2)
result = itertools.product(comb1, comb2)
result = [list(itertools.chain.from_iterable(x)) for x in result]

[['a', 'b', 'c', 1, 2],
 ['a', 'b', 'c', 1, 3],
 ['a', 'b', 'c', 2, 3],
 ['a', 'b', 'd', 1, 2],
 ['a', 'b', 'd', 1, 3],
 ['a', 'b', 'd', 2, 3],
 ['a', 'c', 'd', 1, 2],
 ['a', 'c', 'd', 1, 3],
 ['a', 'c', 'd', 2, 3],
 ['b', 'c', 'd', 1, 2],
 ['b', 'c', 'd', 1, 3],
 ['b', 'c', 'd', 2, 3]]

>>> from itertools import combinations
>>> list1 = ["a", "b", "c", "d"]
>>> list2 = [1, 2, 3]
>>> [[*x, *y] for x in combinations(list1, 3) for y in combinations(list2, 2)]
[['a', 'b', 'c', 1, 2], ['a', 'b', 'c', 1, 3], ['a', 'b', 'c', 2, 3], ['a', 'b', 'd', 1, 2], ['a', 'b', 'd', 1, 3], ['a', 'b', 'd', 2, 3], ['a', 'c', 'd', 1, 2], ['a', 'c', 'd', 1, 3], ['a', 'c', 'd', 2, 3], ['b', 'c', 'd', 1, 2], ['b', 'c', 'd', 1, 3], ['b', 'c', 'd', 2, 3]]