ClearAll[noway];
noway[f_][x_ /; False] := f[x];

expr = noway[Print[{##}]&][x]
(*noway[Print[{##1}]&][x]*)

expr /. x_ /; Head[Head[x]] === foo :> bar

{##1}

Head[Head[expr]]
Head[Head[expr]] === foo
(*noway*)
(*False*)