1st tab

<Mandarinka> mode - constant quality (unless you need exact filesizes)
<Mandarinka> deblocking yes, 0:0 for the parameters
<Mandarinka> profile high
<haijime> :P
<Mandarinka> avc level autoguess

2nd tab

chroma ME yes
merange 16
ME algorithm multiple hexagon
subpixel refinement - I'd say 9, if you want it faster, go 7
cabac - yes
number of rereernce frames - 6-16, with anime every bit helps a little, but it gets progressively slower
mixed reference frames - yes
trellis - 2 (1 for speeding up)
psy-rd strenght  -- hmm, it'S new so I'd say 0.8 is enough
psy-trellis: leave off, expereimntal, dunno where it helps
no dct decimation - leave off, only for high bitrates to keep all the noise
no-fast p-skip - allegedly it improves quality a bit, but it slows down teh encoding



3rd tab

macroblock options -- custom, everything checked (or just choose all). you can get it faster for presumably low or no qualtiy drop if you exclude p4x4 (that type is seldom useful to the encoder, or so they say)

adaptive quantization
mode - variance aq
strenght: 0.7 (more will prevent banding and blocking in falt backgrounds and solid areas better, but it costs bits; I'd say thsi could be enough)

B-frames
number of b.f. - 4-6 (as the count increases, the speed drops)
adaptive b-frames - 2-optimal
b-pyramid - yes. except if you want to play it on sony psp or some toy like that
weighted b-prediction - yes
b-frame mode - spatial or auto (auto shouldn't be much slower and is somewhat better)