df['new']= '{"A1":'+str(df['A1'].item())+
           ',"A2":'+str(df['A2'].item()) +"}"

import pandas as pd
import numpy as np

df = pd.DataFrame(np.random.rand(5,2))

dicts = []
for row in df.itertuples():
    dicts.append({df.columns[0]: row._1, df.columns[1]: row._2})

packed_blobs = [pack(x) for x in dicts]

dt = np.dtype(('column_name', 'blob_format'))
x = np.array(packed_blobs, dtype=dt)
df['new_col'] = x