public partial class Form1 : Form {
    public Form1() {
        InitializeComponent();
        this.BackColor = Color.White;
        panel1.BackColor = Color.FromArgb(25, Color.Black);
    }
    protected override void OnPaint(PaintEventArgs e) {
        e.Graphics.DrawLine(Pens.Yellow, 0, 0, 100, 100);
    }
}

public class TransparentPanel : Panel
{
    protected override CreateParams CreateParams
    {
        get {
            CreateParams cp =  base.CreateParams;
            cp.ExStyle |= 0x00000020; // WS_EX_TRANSPARENT
            return cp;
            }
    }
    protected override void OnPaintBackground(PaintEventArgs e)
    {
        //base.OnPaintBackground(e);
    }
}

Public Class TransparentPanel
Inherits Panel
    Protected Overrides ReadOnly Property CreateParams() As System.Windows.Forms.CreateParams
        Get
            Dim cp As CreateParams = MyBase.CreateParams
            cp.ExStyle = cp.ExStyle Or &H20 ''#WS_EX_TRANSPARENT
            Return cp
        End Get
    End Property
    Protected Overrides Sub OnPaintBackground(ByVal e As System.Windows.Forms.PaintEventArgs)
    ''#MyBase.OnPaintBackground(e)
    End Sub
End Class

public class TransparentPanel : Panel
{
    protected override CreateParams CreateParams
    {
        get
        {
            CreateParams cp = base.CreateParams;
            cp.ExStyle |= 0x00000020; // WS_EX_TRANSPARENT
            return cp;
        }
    }

    protected override void OnPaint(PaintEventArgs e)
    {
        e.Graphics.FillRectangle(new SolidBrush(this.BackColor), this.ClientRectangle);
    }
}

panel1.BackColor = Color.FromArgb(100, 88, 44, 55);

panel1 = new TransparentPanel();
panel1.BackColor = System.Drawing.Color.Transparent;
panel1.Location = new System.Drawing.Point(0, 0);
panel1.Name = "panel1";
panel1.Size = new System.Drawing.Size(717, 92);
panel1.TabIndex = 0;
tab2.Controls.Add(panel1);
panel1.BringToFront();

Imports System.Windows.Forms

Imports System.Drawing.Printing.PrintEventArgs