Nootropic Powder γ -aminobutyric acid (GABA) For Brain Devel

Nootropic Powder γ -aminobutyric acid (GABA) For Brain Development CAS No.: 56-12-2

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Synonym: Gamma Aminobutyric Acid; 4-Aminobutyric acid; GABA; Gamma-Aminobutyric acid; Piperidinic acid; 4-AMINOBUTANOIC ACID; 4-AMINOBUTYRIC ACID; 4-AMINO-N-BUTYRIC ACID; GABA; GAMMA-AMINOBUTYRIC ACID; GAMMA-AMINO-N-BUTYRIC ACID; PIPERIDIC ACID; PIPERIDINIC ACID;
CAS No.: 56-12-2
EINECS No.: 200-258-6
Molecular formula: C4H9NO2
Molecular weight: 103.12
Content: 99%
Packing: 25KG/Drum
Appearance: White powder
Grade: Food grade
Category: Food additives

γ-Aminobutyric acid or GABA) is the chief inhibitory neurotransmitter in the mammaliancentral nervous system. It plays the principal role in reducing neuronalexcitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone.

γ Aminobutyric acid (GABA) is a kind of natural amino acid, which is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays a role in regulating neuronal excitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone. When the level of GABA in the brain decreases below a certain level seizures and other neurological disorders may occur. GABA can act as a natural calming and antiepileptic agent in the brain, also increases levels , which is desirable to most adults since this hormone allows children and teenagers to grow and gain weight increase muscle mass without putting on extra pounds.

γ -aminobutyric acid (GABA) Function:

Neurotransmitter
In vertebrates, GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neuronal processes. This binding causes the opening of ion channels to allow the flow of either negatively charged chloride ions into the cell or positively charged potassium ions out of the cell. This action results in a negative change in the transmembrane potential, usually causing hyperpolarization. Two general classes of GABA receptor are known: GABAA in which the receptor is part of a ligand-gated ion channel complex, and GABAB metabotropic receptors, which are G protein-coupled receptors that open or close ion channels via intermediaries

Brain development
While GABA is an inhibitory transmitter in the mature brain, its actions are primarily excitatory in the developing brain. The gradient of chloride is reversed in immature neurons, and its reversal potential is higher than the resting membrane potential of the cell; Activation of a GABA-A receptor thus leads to efflux of Cl- ions from the cell, i. e. A depolarizing current. The differential gradient of chloride in immature neurons is primarily due to the higher concentration of NKCC1 co-transporters relative to KCC2 co-transporters in immature cells. GABA itself is partially responsible for orchestrating the maturation of ion pumps. GABA-ergic interneurons mature faster in the hippocampus and the GABA signalling machinery appears earlier than glutamatergic transmission. Thus, GABA is the major excitatory neurotransmitter in many regions of the brain before the maturation of glutamatergic synapses.

Profile:

GABA is an amino acid mostly found in human eyes and brain.  It is an inhibitory neurotransmitter and the brain's natural calming agent.  This means it promotes relaxation, eases anxiety, and nervous tension.  Therefore, those who need to calm down and relax, especially before retiring to their bedroom for the night, will find GABA supplementation beneficial.

GABA is also capable of increasing human growth hormone in the body, which makes it popular among athletes and especially bodybuilders.

Description:

Since it was discovered in 1950, almost 50,000 papers have been published about GABA.   Amazingly, very few of those focused on using GABA as a supplement, as they have mostly been centered around the mechanisms of action only.  This has led to speculation that the drug companies do not want GABA to become mainstream,  fearing to lose revenue from anxiety drugs .

Nevertheless, the studies that have been done have shown that GABA works well as a tranquilizer with a calming effect.  In that same study for example, a 40 year old woman who suffered from extreme anxiety was given a strong dose of GABA, and her anxiety disappeared.

Application:

GABA works by regulating brain and nerve activity via inhibiting a number of neurons working in the brain.  An excess of norepinephrine/adrenaline can make our brains experience abundance of tension, stress, and nervousness.    Our body is smart in this situation, and will work to neutralize this via releasing GABA, which will inhibit this extra adrenaline.   Adding GABA supplementation can go a long way to aid the body in this inhibition, and overcoming nights of tossing and turning.

Without GABA, nerve cells fire too often and too frequently, which will lead to anxiety disorders and even conditions like addiction, headaches, and Parkinson's syndrome.

For bodybuilding:
Sleep is crucial for athletes because this is the time when recovery takes place.   Bodybuilders can benefit from GABA use to help them relax after a strong workout, and to help them improve their sleep as part of a supplemental stack.

Dosage:

If you run GABA solo, the dosages can range from 250mg up to 750mg per day.  As part of a supplemental stack typical dosages are much lower as they work in synergy with other ingredients like melatonin.

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