CREATE SEQUENCE IF NOT EXISTS serial;
CREATE TABLE my_tbl (
    fname    varchar(100),
    lname    varchar(100),
    company  varchar(200),
    id       integer PRIMARY KEY DEFAULT nextval('serial')
);

conn = psycopg2.connect(dbname=dbname, host=host, port=port, user=user, password=pwd)
cur = conn.cursor()
cur.copy_expert("copy {} from STDIN CSV HEADER QUOTE '"'".format(table_name), file)
cur.execute("commit;")