mySQLConnection iConn = new mySQLConnection();  /*Ceate and open connection*/
String insertQuery = "INSERT INTO computer_screen(filecontent) VALUES(@filecontent)";
MySqlCommand command = new MySqlCommand(insertQuery, iConn.mcon);

command.Parameters["@filecontent"].Value =     File.ReadAllBytes(@"C:\err_0422_114255.jpg");
command.ExecuteNonQuery();

CREATE TABLE `computer_screen` (
  `id`           int AUTO_INCREMENT NOT NULL,
  `filecontent`  blob,
  /* Keys */
  PRIMARY KEY (`id`)
) ENGINE = MyISAM;