PiT things to try

Before Hollijolli Village
Shroob saucer cutscene skip - oob in the trees similar to this https://www.youtube.com/watch?v=Fs_cqkrXByU Then, walk past the cutscene trigger.

Toadwood Forest
TSS in fire puzzle to skip burning the trees. No known method of TSS, if there was a way exiting with the babies softlocks. This seems unlikely to work.

Vim Factory
Rescue adults early - oob in the room to the left after beating Hammer bros. I tried to ledge clip, couldn't get it but it might be possible.

Gritzy Desert
Gritzy Desert skip (faster and working on console) This was close https://www.youtube.com/watch?v=6f4t2ENbTT4

Gritzy Caves
Figure out how "warping" works and find a consistent setup for the 1st section skip

Thwomp Volcano
Apply TSS from the cloud and yellow wall room. E gadd cutscene skip is unlikely to save time. Maybe Mrs. Thwomp skip? What I'm really interested in is Thwomp Caverns skip, get the adults oob in the room with 3 pipes in the volcano, and go in the third pipe. Would likely require real adults on the bottom and top screen.

Star Hill
Commander Shroob skip - Adults can enter one of the top-screen loading zones with ball, store it then exit in ball can skip commander shroob. However the adults can't access that lz.

Shroob Castle
Find a way to get the adults into the dark room. Exit when the babies are in the 3-pipe room, enter the right-most pipe to skip all of the castle.

And yeah, gate skip and toad town early. We'd probably need an entirely new glitch to do those though.