import pandas as pd
d = {'col1': [1,"newcolumn1name",5, 8,15 ], 'col2':[5,"newcolumn2name"10,15, 20]}
df = pd.DataFrame(data=d)
df1=df
df2=df

df
Out[24]:
             col1            col2
0               1               5
1  newcolumn1name  newcolumn2name
2               5              10
3               8              15
4              15              20

df=df[1:]
new_header = df.iloc[0]
df=df[1:]
df.columns = new_header

df
Out[26]:
1 newcolumn1name newcolumn2name
2              5             10
3              8             15
4             15             20