Contents

Declaration
Recommendation
Abstract
List of Acronyms
List of Symbols
List of Tables
List of Figures
List of Schemes
Chapter One
1.1 Introduction
1.2 Statement of the Problem
1.3 Objectives
1.4 Justification and Significance of the Study
Chapter Two
2.1 Literature Review
2.1.1 Albizia Description(Tephrosia)
2.1.2 Ethnomedical and Botanical Information of Albizia(Tephrosia)
2.1.3 Phytochemistry of Albizia(Tephrosia)
2.2 Computational Studies
2.3 Syntheses of the Macrocyclic Spermine Alkaloids
2.3.1 Synthesis
Chapter Three
3.1 Methodology
3.1.1 Computational Studies
3.1.1.1.1 Target Protein
3.1.1.1.2 Ligand(Budmunchiamines)
3.1.1.1.3 Molecular Docking Simulation
3.1.3 Synthesis of the Budmunchiamine Analogue
3.1.4 Biological Evalution of the Compounds
Expected Outcomes
References
Budget
Work Plan