No known remedy, blessing, or ritual has effectively purged the curse of lycanthropy. The closest anyone ever came was alchemist Theodora Glick, who was brought in to inspect Guthril, a werewolf captured by the local constabulary. Through a complex ceremony involving mystic circles inlaid with the wolfsbane plant, a blanket woven with blessed silver thread, and a lightning storm, Glick managed to force Guthril to revert to human form and stay that way through three lunar cycles. Unfortunately, the ritual was only temporary, and Guthril re-emerged stronger than ever. He utterly destroyed Glick's laboratory in Gavony and fled into the night.

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PLANESWALKER'S GUIDE TO INNISTRAD: KESSIG AND WEREWOLVES