111 Straight OTPs

Eric Cartman and Heidi Turner (South Park, season 20 *only*)
Mysterion and Henrietta Biggle (South Park: The Fractured But Whole)
Sterling Archer and Pam Poovey (Archer)
Tina Belcher and Jimmy Pesto, Jr. (Bob's Burgers)
BoJack Horseman and Princess Carolyn (Bojack Horseman)
Rigby and Eileen Roberts (Regular Show)
Arnold Shortman and Helga Pataki (Hey Arnold!)
Harold Berman and Patty Smith (Hey Arnold!)
Lincoln Loud and Ronnie-Anne Santiago (The Loud House)
Darwin and Carrie (The Amazing World of Gumball)
Dipper Pines and Mabel Pines (Gravity Falls) (pls don't judge pinecest is pure)
Buzz Lightyear and Jessie the Yodeling Cowgirl (Toy Story franchise)
Wreck-It Ralph and Vanellope von Schweetz (Wreck-It Ralph franchise) (SUPER don't judge)
Nick Wilde and Judy Hopps (Zootopia)
Po and Tigress (Kung Fu Panda franchise)
Norman Babcock and Coraline Jones (ParaNorman + Coraline shared universe from /co/)
Shaggy Rogers and Velma Dinkley (Scooby-Doo: Mystery Incorporated)
Donatello and April O'Neil (Teenage Mutant Ninja Turtles 2012)
Silverbolt and Blackarachnia (Beast Wars: Transformers)
Matrix and AndrAIa (Reboot)

Vision and Wanda Maximoff (Marvel Cinematic Universe)
Bruce Banner and Natasha Romanoff (Marvel Cinematic Universe)
Drax and Mantis (Marvel Cinematic Universe)
Leo Fitz and Jemma Simmons (Marvel's Agents of SHIELD)
Danny Rand and Colleen Wing (Marvel's Iron Fist)
Kitty Pryde and Lance Alvers (X-Men Evolution)
Gene Khan and Pepper Potts (Iron Man: Armored Adventures)
Amadeus Cho and Delphyne Gorgon (The Incredible Herc)
Chase Stein and Gert Yorkes (Runaways)
Cassie Lang and Jonas (Young Avengers)
Franklin Richards and Katie Power (Power Pack)
Leonard Snart and Sarah Lance (DC's Legends of Tomorrow)
Damian Wayne and Rachel Roth (DC Animated Movie Universe)
Vic Sage and Helena Bertinelli (Justice League Unlimited)
Conner Kent and M'gann M'orzz (Young Justice, season 1 *only*)
Razer and Aya (Green Lantern the Animated Series)
Brainiac 5 and Shrinking Violet (Legion of Super-Heroes 2006)
Cyborg and Jinx (Teen Titans 2003, Teen Titans Go!)

Abed Nadir and Annie Edison (Community)
Andy Dwyer and April Ludgate (Parks and Recreation)
Jim Halpert and Pam Beesly (The Office)
Jake Peralta and Amy Santiago (Brooklyn Nine-Nine)
John "JD" Dorian and Elliot Reid (Scrubs)
Blake Anderson and Jillian Belk (Workaholics)
Daniel Jackson and Vala Mal Doran (Stargate SG-1)
Rodney McKay and Jennifer Keller (Stargate Atlantis)
Simon Tam and Kaylee Frye (Firefly)
Jayne Cobb and River Tam (Firefly)
Connor and Dawn Summers (Buffyverse)
Xander Harris and Anya Jenkins (Buffy the Vampire Slayer)
Angelus and Darla (Angel)
Hiro Nakamura and Charlie Andrews (Heroes)
Sherlock Holmes and Molly Hooper (Sherlock)
Amy Pond and Rory Williams (Doctor Who)
The 11th Doctor and River Song (Doctor Who)
Raleigh Becket and Mako Mori (Pacific Rim)
Worf Rozhenko and Jadzia Dax (Star Trek: Deep Space Nine)
Jaime Lannister and Brienne of Tarth (Game of Thrones)
Ramsay Bolton and Myranda (Game of Thrones)

Fuuka Igasaki and Kinji Takigawa (Shuriken Sentai Ninninger)
Hikari Nonomura and Kagura Izumi (Ressha Sentai ToQger)
Rio and Mele (Juken Sentai Gekiranger)
Eiji Hino and Hina Izumi (Kamen Rider OOO)
Kaito Kumon and Yoko Minato (Kamen Rider Gaim)
Shigeru Jou and Yuriko Misaki (Kamen Rider Stronger)

Yamato Ishida and Sora Takenouchi (Digimon Adventure)
Daisuke Motomiya and Hikari Yagami (Digimon Adventure 02)
Takato Matsuda and Juri Katou (Digimon Tamers)
Ryouga Hibiki and Ukyo Kuonji (Ranma 1/2)
Rock Lee and Tenten (Naruto, Naruto Shippuden, and Rock Lee and His Ninja Pals)
Boruto Uzumaki and Sumire Kakei (Boruto: Naruto Next Generations)
Krillin and Lazuli (Dragon Ball Super)
Broly and Cheelai (Dragon Ball Super)
Trunks and Mai (Dragon Ball Super)
Soul Eater Evans and Maka Albarn (Soul Eater)
Lin Yao and Lan Fan (Fullmetal Alchemist)
Karma Akabane and Manami Okuda (Assassination Classroom)
Izuku Midoriya and Ochaco Uraraka (Boku no Hero Academia)
Shoto Todoroki and Momo Yaoyorozu (Boku no Hero Academia)
Tenya Iida and Hatsume Mei (Boku no Hero Academia)
Tsuyu Asui and Fumikage Tokoyami (Boku no Hero Academia)
Bossun and Himeko (SKET Dance)
Switch and Reiko Yuuki (SKET Dance)
Kagura and Sougo Okita (Gintama)
Ira Gamagoori and Mako Mankanshoku (Kill la Kill)
Kazuma Satou and Darkness (Kono Subarashii Sekai ni Shukufuku wo!)
Yuuta Togashi and Rikka Takanashi (Chuunibyou no Koi Demo ga Shitai!)
Mahiro Yasaka and Nyaruko (Nyaruko: Crawling with Chaos)
Tomoya Okazaki and Nagisa Furukawa (Clannad and Clannad: After Story)
Isaac Dian and Miria Harvent (Baccano! and DRRR!)
Shinji Ikari and Rei Ayanami (Neon Genesis Evangelion franchise) (don't judge)
Simon Jiha and Nia Teppelin (Tengen Toppa Gurren-Lagann)
Kotaro Inugami and Natsumi Murakami (Mahou Sensei Negima)
Kyuubi and Katie Forester (Yo-kai Watch)

Shinjiro Aragaki and Kotone Shiomi (Persona 3)
Junpei Iori and Fuuka Yamagishi (Persona 3)
Kanji Tatsumi and Naoto Shirogane (Persona 4)
Yusuke Kitagawa and Futaba Sakura (Persona 5)
Makoto Naegi and Mukuro Ikusaba (Danganronpa IF)
Hajime Hinata and Chiaki Nanami (Super Danganronpa 2)
Fuyuhiko Kuzuryu and Peko Pekoyama (Super Danganronpa 2)
Nekomaru Nidai and Akane Owari (Super Danganronpa 2)
Sonia Nevermind and Gundham Tanaka (Super Danganronpa 2)

Hal Emmerich and Emma Emmerich (Metal Gear Solid franchise) (don't judge)
Marluxia and Larxene (Kingdom Hearts franchise)
Pence and Olette (Kingdom Hearts franchise)
Incineroar and Isabelle (Super Smash Bros Ultimate)
Ellis and Zoey (Left 4 Dead franchise)
Leon Kennedy & Ada Wong (Resident Evil franchise)
Rhys Strongfork and Fiona (Tales from the Borderlands)
9S and 2B (NieR: Automata)