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- Importance of IQ
- https://mpra.ub.uni-muenchen.de/76922/1/MPRA_paper_76922.pdf
- https://archive.li/n5Sxv
- https://archive.li/MGxWa
- Genes matter a lot, generally
- http://news.ubc.ca/2015/05/06/how-your-brain-reacts-to-emotional-information-is-influenced-by-your-genes/
- Other metrics which matter
- https://www.sciencedirect.com/science/article/abs/pii/S0047272711001381
- Epigenetics
- https://whyevolutionistrue.wordpress.com/2018/05/29/the-flimsy-evidence-for-epigenetic-changes-in-dna-to-be-transmitted-between-generations-of-humans/amp/?__twitter_impression=true
- Methylation specifically
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759714/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730924/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334571/
- Racial Bias/Contact Research
- http://news.msu.edu/media/documents/2011/06/f729e36e-e050-45e0-b6cf-27eb8a71bcfc.pdf
- https://web.archive.org/web/20180607092748/http://news.msu.edu/media/documents/2011/06/f729e36e-e050-45e0-b6cf-27eb8a71bcfc.pdf
- http://www.cdnresearch.net/pubs/2015_McDonald_Navarrete_PsychScience.pdf
- https://web.archive.org/web/20180607093011/http://www.cdnresearch.net/pubs/2015_McDonald_Navarrete_PsychScience.pdf
- Miscegenation
- https://archive.li/g85sz
- https://archive.fo/P9Ghc
- http://archive.is/P9Ghc
- http://www.nber.org/papers/w14192
- http://www.nber.org/papers/w14192
- https://www.npr.org/2017/12/07/568948782/black-mothers-keep-dying-after-giving-birth-shalon-irvings-story-explains-why
- https://www.npr.org/sections/codeswitch/2013/11/30/247530095/are-you-interested-dating-odds-favor-white-men-asian-women
- https://archive.fo/ISpHM
- https://web.archive.org/web/20160320234245/http://www.jkp.com/uk/mixed-experiences.html
- Other mental traits
- https://www.sciencedirect.com/science/article/abs/pii/S0047272711001381
- http://news.ubc.ca/2015/05/06/how-your-brain-reacts-to-emotional-information-is-influenced-by-your-genes/
- Expert Opinion
- http://www.intelligence.martinsewell.com/Gottfredson1997.pdf
- Criticisms of HBD/Hereditarianism
- https://www.madinamerica.com/2013/03/the-trouble-with-twin-studies/
- https://www.ethnicity-facts-figures.service.gov.uk/education-skills-and-training/a-levels/students-aged-16-to-18-achieving-3-a-grades-or-better-at-a-level/latest
- Criticisms of critics
- https://www.bitchute.com/video/t5TbcrRbpUAu/
- http://emilkirkegaard.dk/en/?p=7257
- http://emilkirkegaard.dk/en/?p=7257
- https://preservingeurope.wordpress.com/2018/01/04/shaun-vs-the-great-replacement-anti-white-rhetoric-refuted-part-1/
- Morphological differences
- https://www.cell.com/current-biology/pdf/S0960-9822(15)00671-5.pdf
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862912/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361742/
- http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013642
- https://scholar.google.com/scholar?hl=en&as_sdt=0%2C31&as_vis=1&q=african+humans+brain+structure&btnG=#d=gs_qabs&p=&u=%23p%3Doa7SPw_9iysJ
- https://drive.google.com/file/d/1ICXVn7QK4QE3x1g7vcKoSJihYycOFQAl/view
- Medical differences
- https://www.npr.org/2017/12/07/568948782/black-mothers-keep-dying-after-giving-birth-shalon-irvings-story-explains-why
- Past European Thought on Race
- https://books.google.com/books?id=0kQgSKlUFa8C&printsec=frontcover&dq=race+and+redemption+new+england&hl=en&sa=X&ved=0ahUKEwj4q52r7tXbAhWjwFkKHQ6RA2oQ6AEIJzAA#v=onepage&q=race%20and%20redemption%20new%20england&f=false
- Sex Realism
- https://cepa.stanford.edu/sites/default/files/wp18-13-v201806_0.pdf
- Lead, apparently
- https://www.vox.com/a/lead-exposure-risk-map
- https://www.huffingtonpost.com/entry/most-dangerous-cities-florida_n_4524866
- Academia, the absolute state of
- https://drive.google.com/file/d/0B3c4TxciNeJZOTl3clpiX0JKckk/view
- Immigracion
- https://drive.google.com/file/d/0B7Y5iblDQOJBUURmWHhsRXowV3M/view
- https://drive.google.com/file/d/0B7Y5iblDQOJBUURmWHhsRXowV3M/view
- https://www.census.gov/prod/cen2010/briefs/c2010br-01.pdf
- Huwite Flight
- https://pastebin.com/iekxMVFP
- https://www.theatlantic.com/business/archive/2015/07/white-flight-alive-and-well/399980/
- Ethnic nepotism and politicking
- http://www.foxnews.com/politics/2018/03/08/mexican-presidential-hopeful-campaigns-in-california-slams-trump-and-backs-illegal-immigrants.html
- Autosegregation
- http://sci-hub.tw/https://doi.org/10.1371/journal.pgen.1004572
- http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042702
- European Genetics
- https://commons.m.wikimedia.org/wiki/File:European_genetic_structure_(based_on_SNPs)_PC_analysis.png
- Social Media Debates
- https://archive.li/heskD
- https://archive.li/RA7Vh
- https://archive.li/FO7Ji
- https://archive.li/5sr8E
- https://elifesciences.org/articles/09343
- https://archive.li/7xL92
- https://archive.li/6u69l
- https://archive.li/u5Mx0
- https://archive.li/v8ryH
- https://archive.li/IW6Ln
- https://archive.li/7YY11
- https://archive.li/9C6bq
- https://archive.li/BlKCa
- http://www.pnas.org/content/114/5/e727
- https://archive.li/dNKec
- https://archive.li/LRE8o
- https://archive.li/nGMGt
- https://www.youtube.com/watch?v=etMmhzQL3ho&feature=youtu.be
- Other pastebins and resources
- https://redpilled.club
- https://www.reddit.com/r/HBD/
- https://pastebin.com/u/maxred
- https://www.bitchute.com/video/t5TbcrRbpUAu/
- Sean last's old and current blog:
- http://archive.is/spawktalk.blogspot.com
- https://ideasanddata.wordpress.com/
- Althype old and new site:
- http://neweuropeanp.tumblr.com/
- http://thealternativehypothesis.org/
- Preprint server for biology papers:
- https://www.biorxiv.org/
- Most cited papers in "Intelligence"
- https://www.journals.elsevier.com/intelligence/most-cited-articles
- HBD:
- http://archive.is/6xRv8
- Kirkegaard blog: (+all his papers)
- http://emilkirkegaard.dk/
- David piffer's work:
- https://openpsych.net/person/5
- Metapedia:
- http://en.metapedia.org/wiki/Main_Page
- Library of hate:
- https://libraryofhate.com/
- True Dil tom doc:
- https://docs.google.com/document/d/1n6b_-2gRE_ewAST716x8VwQtn4LuxFPE3kpmeFTMetw/edit?usp=drivesdk
- My doc:
- https://docs.google.com/document/d/14vxK0EYTdnqk_wKCQWYkA9TARzMhqe1uhgxegk5DvFg/edit?usp=drivesdk
- Audacious epigone:
- http://anepigone.blogspot.com/?m=1
- Francis the Guido:
- https://preservingeurope.wordpress.com/
- Arguments for our position
- Matty: I talk about the 80% general Heritability of IQ after 12 years old mostly.
- But they're not exactly wrong. IQ has a crystallized element that you have to control for. That's why distilling g and finding its Heritability is better. Fourth stage did that a couple days ago. Rushton did it as a career for a decade lol
- We've also got GWAS hits, mutational load, evidence for selection in the brain transcriptome, frontal lobe volume, Spearman analyses, personality research, Dan Friedman's stuff on neonate behavior. Every little morsel of research ever done on the subject calls back to a rich history- no, histories, plural- of natural selection operating on the brain in different environments across the globe.
- Me: basically going through each category and showing it's doubtful and how environmental explanations have to get more and more nebulous to cope with this (SES doesnt cause the gap so it must be systems of oppression!)
- Replies to critics
- Debunking Denialism:
- thealternativehypothesis.org/index.php/2016/05/04/debunking-a-denier-part-1-the-existence-of-race-race-iq/
- thealternativehypothesis.org/index.php/2016/05/05/debunking-a-denier-part-2-race-and-crime/
- thealternativehypothesis.org/index.php/2017/02/24/first-worldism-part-3-the-heritability-of-political-views/
- Expert Opinion
- http://www.intelligence.martinsewell.com/Gottfredson1997.pdf
- http://emilkirkegaard.dk/en/wp-content/uploads/2013-survey-of-expert-opinion-on-intelligence.pdf
- General chat essays:
- SUBJECT MATTER: WHITE PREGNANT FEMALES FEAR OF BLACK MEN- REPLICATED STUDIES
- 1.) McDonald-"Fertility and Intergroup Bias in Racial and Minimal-Group Contexts: Evidence for Shared Architecture
- McDonald: "Recent research has shown that White women’s bias against Black men increases with elevated fertility across the menstrual cycle. We demonstrate that the association between fertility and intergroup bias is not limited to groups defined by race, but extends to group categories that are minimally defined, and may depend on the extent to which women associate out-group men with physical formidability. In Study 1, Black and White women with strong associations between the racial out-group and physical formidability displayed greater bias against out-group men as conception risk increased. Study 2 replicated these results in a minimal-group paradigm. These findings are consistent with the notion that women may be endowed with a psychological system that generates intergroup bias via mechanisms that rely on categorization heuristics and perceptions of the physical formidability of out-group men, particularly when the costs of sexual coercion are high.
- https://www.jstor.org/stable/25835467?seq=1#page_scan_tab_contents
- SUBJECT MATTER: WHITE PREGNANT FEMALES FEAR OF BLACK MEN- REPLICATED STUDIES
- 2.) McDonald:"Examining the Link Between Conception Risk and Intergroup Bias: The Importance of Conceptual Coherence-Replication"
- McDonald:"Evolutionary approaches to intergroup bias have predominantly
- focused on male perpetrators of bias (e.g., Sidanius & Pratto, 1999; Van Vugt, De Cremer, & Janssen,
- 2007; Wrangham & Peterson, 1996). However, recent research has examined how the motivations for intergroup
- bias may differ between men and women, providing evidence for a female-specific psychology of prejudice
- against out-group men that is linked to changes in conception risk across the menstrual cycle (McDonald, Asher,
- Kerr, & Navarrete, 2011; Navarrete, Fessler, Fleischman, & Geyer, 2009). Hawkins, Fitzgerald, and Nosek (2015)
- reported a putative failure to confirm this link in a series of replication attempts. Here, we offer three important
- critiques of their replication attempts that should help clarify these apparent inconsistencies. The most important
- critique involves the theoretical coherence of the conceptual replications—specifically, the use of female
- target stimuli in research purportedly aimed at investigating the workings of a psychological system for the avoidance of sexual coercion. Our Commentary is intended to improve understanding of the theoretical arguments
- underlying key predictions in order to facilitate the continued coherence of research in this important area."
- Retype: "Evolutionary approaches to intergroup bias have predominantly
- focused on male perpetrators of bias (e.g.,
- Sidanius & Pratto, 1999; Van Vugt, De Cremer, & Janssen,
- 2007; Wrangham & Peterson, 1996). However, recent
- research has examined how the motivations for intergroup
- bias may differ between men and women, providing
- evidence for a female-specific psychology of prejudice
- against out-group men that is linked to changes in conception
- risk across the menstrual cycle (McDonald, Asher,
- Kerr, & Navarrete, 2011; Navarrete, Fessler, Fleischman, &
- Geyer, 2009). Hawkins, Fitzgerald, and Nosek (2015)
- reported a putative failure to confirm this link in a series
- of replication attempts. Here, we offer three important
- critiques of their replication attempts that should help
- clarify these apparent inconsistencies. The most important
- critique involves the theoretical coherence of the
- conceptual replications—specifically, the use of female
- target stimuli in research purportedly aimed at investigating
- the workings of a psychological system for the avoidance
- of sexual coercion. Our Commentary is intended to
- improve understanding of the theoretical arguments
- underlying key predictions in order to facilitate the continued
- coherence of research in this important area.
- SUBJECT MATTER: EPIGENETICS AND RACE
- 1.) Genome-Wide Variation of Cytosine Modifications Between European and African Populations and the Implications for Complex Traits
- Moen:"Elucidating cytosine modification differences between human populations can enhance our understanding of ethnic specificity in complex traits. In this study, cytosine modification levels in 133 HapMap lymphoblastoid cell lines derived from individuals of European or African ancestry were profiled using the Illumina HumanMethylation450 BeadChip. Approximately 13% of the analyzed CpG sites showed differential modification between the two populations at a false discovery rate of 1%. The CpG sites with greater modification levels in European descent were enriched in the proximal regulatory regions, while those greater in African descent were biased toward gene bodies. More than half of the detected population-specific cytosine modifications could be explained primarily by local genetic variation. In addition, a substantial proportion of local modification quantitative trait loci exhibited population-specific effects, suggesting that genetic epistasis and/or genotype · environment interactions could be common. Distinctcorrelations were observed between gene expression levels and cytosine modifications in proximal regions and gene bodies, suggesting epigenetic regulation of interindividual expression variation. Furthermore, quantitative trait loci associated with population-specific modifications can be colocalized with expression quantitative trait loci and single nucleotide polymorphisms previously identified for complex traits with known racial disparities. Our findings revealed abundant population-specific cytosine modifications and the underlying genetic basis, as well as the relatively independent contribution of genetic and epigenetic variations to population differences in gene expression."
- PLEASE READ THE LAST LINE OF THAT ABSTRACT
- 2.) DNA methylation contributes to natural human variation-THIS STUDY PROVES THAT THE MAJORITY OF METHYLATION VARIATION IS FROM GENETIC VARIATION
- Heyn:" DNA methylation differences can be partially traced back to genetic variation,
- suggesting that differentially methylated CpG sites serve as evolutionarily established mediators between the
- genetic code and phenotypic variability. Notably, one-third of the DNA methylation differences were not associated with any genetic variation, suggesting that variation in population-specific sites takes place at the genetic and epigenetic levels, highlighting the contribution of epigenetic modification to natural human variation.
- 1.) McDonald-"Fertility and Intergroup Bias in Racial and Minimal-Group Contexts: Evidence for Shared Architecture
- http://news.msu.edu/media/documents/2011/06/f729e36e-e050-45e0-b6cf-27eb8a71bcfc.pdf
- https://web.archive.org/web/20180607092748/http://news.msu.edu/media/documents/2011/06/f729e36e-e050-45e0-b6cf-27eb8a71bcfc.pdf
- 2.) McDonald:"Examining the Link Between Conception Risk and Intergroup Bias: The Importance of Conceptual Coherence-Replication"
- http://www.cdnresearch.net/pubs/2015_McDonald_Navarrete_PsychScience.pdf
- https://web.archive.org/web/20180607093011/http://www.cdnresearch.net/pubs/2015_McDonald_Navarrete_PsychScience.pdf
- NEW TOPIC
- SUBJECT MATTER: EPIGENETICS AND RACE
- 1.) Genome-Wide Variation of Cytosine Modifications Between European and African Populations and the Implications for Complex Traits
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730924/
- http://archive.is/PAXOt
- 2.) DNA methylation contributes to natural human variation-THIS STUDY PROVES THAT THE MAJORITY OF METHYLATION VARIATION IS FROM GENETIC VARIATION
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759714/
- http://archive.is/FJOoK
- SUBJECT MATTER: TWINS-VALIDITY OF GENETIC PREDISPOSITIONS
- 1)Jacob Felson: What can we learn from twin studies? A comprehensive evaluation of the equal environments assumption
- https://pdfs.semanticscholar.org/6c61/c3c0909c4aee8a72ad2e1c9d629cc200558e.pdf
- https://web.archive.org/web/20180606083159/https://pdfs.semanticscholar.org/6c61/c3c0909c4aee8a72ad2e1c9d629cc200558e.pdf
- 2)Dalton Conley :"Heritability and the Equal Environments Assumption: Evidence
- from Multiple Samples of Misclassified Twins"
- https://link.springer.com/article/10.1007%2Fs10519-013-9602-1
- https://archive.fo/iAXph
- 3.) William G. Iacono: "The utility of twins in developmental cognitive neuroscience research: How
- twins strengthen the ABCD research design"
- https://www.sciencedirect.com/science/article/pii/S1878929317301135
- https://archive.fo/fafiQ
- 4.) Hallgrmsson: "Spatial Coherence of Oriented White Matter Microstructure:
- https://arxiv.org/abs/1802.05342
- https://archive.fo/eRweu
- 5.) Waldman: "Twins’ Rearing Environment Similarity and Childhood
- Externalizing Disorders: A Test of the Equal Environments Assumption"
- https://link.springer.com/article/10.1007%2Fs10519-014-9685-3
- https://archive.fo/fiI6t
- 6.) Mara ten Kate: "White matter hyperintensities and vascular risk factors in
- https://www.sciencedirect.com/science/article/pii/S0197458018300447
- https://archive.fo/wh2lV
- 7.) Cocaro: "Reduced frontal grey matter, life history of aggression, and underlying
- genetic influence"
- https://www.ncbi.nlm.nih.gov/pubmed/29174436
- https://archive.fo/DAFqM
- 8.)Jacob Felson-What Can we Learn From Twin Studies?
- https://pdfs.semanticscholar.org/3ed6/ea579e47a3e7446254c63de8816a368993a7.pdf
- https://web.archive.org/web/20180606084440/https://pdfs.semanticscholar.org/3ed6/ea579e47a3e7446254c63de8816a368993a7.pdf
- SUBJECT MATTER: EPIGENETICS AND RACE
- 1.) Gertz: "Analysis of DNA Methylation in a Three-Generation Family Reveals Widespread Genetic Influence on Epigenetic Regulation"
- http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002228
- https://web.archive.org/save/http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002228
- 2.) Fraser:"Population-specificity of human DNA methylation"
- https://www.ncbi.nlm.nih.gov/pubmed/22322129
- https://archive.fo/YAnsh
- 1.) Manuck:" Racial and ethnic differences in preterm birth: A complex,multifactorial problem"
- https://www.sciencedirect.com/science/article/pii/S0146000517300988
- https://archive.fo/I4V5v
- SUBJECT MATTER: TWINS-VALIDITY OF GENETIC PREDISPOSITIONS
- Jacob Felson: What can we learn from twin studies? A comprehensive evaluation of the equal environments assumption
- Felson: "Results support a middle ground position; it is likely that the EEA is
- not strictly valid for most outcomes, but the resulting bias is likely modest."
- 2.) Dalton Conley :"Heritability and the Equal Environments Assumption: Evidence
- from Multiple Samples of Misclassified Twins"
- Dalton: "Overall, the evidence suggests that typical twin heritability
- estimates of behavioral outcomes are not upwardly biased
- by failing to address the covariance between genes and
- environment. In other words, our evidence supports the
- EEA and lends credence to methods used here and in
- previous studies that compare similarity based on actual
- and perceived zygosity to assess the EEA. Further, our
- results build on previous research to suggest that phenotypic
- similarity and perceived zygosity are not co-determined."
- 3.) William G. Iacono: "The utility of twins in developmental cognitive neuroscience research: How
- twins strengthen the ABCD research design"
- Iacono: "The study of twins has provided compelling evidence of the ubiquitous
- influence of genetics, as well as environments, on important
- human traits ranging from anthropometric characteristics, to physiological
- and biochemical traits, to diseases, and psychological and behavioral
- traits and disorders"
- 4.) Hallgrmsson: "Spatial Coherence of Oriented White Matter Microstructure:
- Applications to White Matter Regions Associated with Genetic Similarity"
- Hallgrmsson :" This method is demonstrated on a population of monozygotic
- (MZ) and dizygotic (DZ) twins, with a control
- group composed of the same individuals with their pairings
- scrambled such as to keep the same demographic proles
- but otherwise form unrelated strangers. The method discovers
- 3.7% of all white matter voxels to be associated with
- genetic similarity (35.1k voxels, p < 104, false discovery
- rate 1.5%), 75% of which form twenty-two contiguous
- white matter regions. These white matter regions generalize
- to a population of non-twin siblings and are shown
- to be a good indicator of genetic similarity there as well,
- as compared to a population of strangers. The regions
- encapsulate nearly all of deep white matter."
- 5.) Waldman: "Twins’ Rearing Environment Similarity and Childhood
- Externalizing Disorders: A Test of the Equal Environments Assumption"
- Waldman: "We found that MZ twins experienced substantially more
- similar rearing environments than DZ twins, but that there
- was little evidence that MZ and DZ correlations for the
- externalizing symptom dimensions varied by rearing
- environment similarity. Thus, these results constitute evidence
- for the validity of the EEA for childhood externalizing
- disorders."
- 6.) Mara ten Kate: "White matter hyperintensities and vascular risk factors in
- monozygotic twins"
- Kate: "The withinetwin pair correlation for total WMHs was 0.76 and for Framingham score was 0.77. Within
- participants, Framingham score was associated with total and periventricular WMHs (r ¼ 0.32). Framingham
- score in 1 twin was also associated with total WMHs in the co-twin (r ¼ 0.26). Up to 83% of the
- relation between both traits could be explained by shared genetic effects. In conclusion, monozygotic
- twins have highly similar vascular risk and WMH burden, confirming a genetic background for these
- traits. The association between both traits is largely driven by overlapping genetic factors"
- 7.) Cocaro: "Reduced frontal grey matter, life history of aggression, and underlying
- genetic influence"
- Cocaro: "Genetic factors accounted for the majority of the
- phenotypic correlations between aggression and mPFC GMV (85.3%) and between aggression and lPFC GMV
- (63.7%). Reduced GMV of prefrontal brain regions may be a neuronal characteristic of individuals with substantial
- histories of aggressive behavior regardless of psychiatric diagnosis. As such, these data suggest an
- anatomical correlate, with a possible genetic etiology, associated with functional deficits in social-emotional
- information processing"
- 8.)Jacob Felson-What Can we Learn From Twin Studies? (2009 Book) (This one is a hard one to find, I got the copy from a pirateer)
- Felson:"The findings are not easily categorized as supporting or undermining the EEA.
- Some violations of EEA were found for some outcomes, but the bias caused by these
- violations is likely to be modest in most cases. Researchers should not conduct twin
- studies without including controls for environmental similarity. However, the findings
- also indicate that many of the results of twin studies are robust with these controls.
- The flaws of twin studies are not fatal, but rather seem no worse (and maybe better)
- than the flaws of the typical causal study that relies on observational data."
- SUBJECT MATTER: EPIGENETICS AND RACE
- NEW TOPIC
- SUBJECT MATTER: EPIGENETICS AND RACE
- 1.) Gertz: "Analysis of DNA Methylation in a Three-Generation
- Family Reveals Widespread Genetic Influence on Epigenetic Regulation"
- Gertz:"We found that 75% of genotype-dependent differential methylation events in
- the family are also seen in unrelated individuals and that overall genotype can explain 80% of the variation in DNA
- methylation. These events are under-represented in CpG islands, enriched in intergenic regions, and located in regions of low evolutionary conservation. Even though they are generally not in functionally constrained regions, 22% (twice as manyas expected by chance) of genes harboring genotype-dependent DNA methylation exhibited allele-specific gene expression as measured by RNA-seq of a lymphoblastoid cell line, indicating that some of these events are associated with gene expression differences. Overall, our results demonstrate that the influence of genotype on patterns of DNA methylation is widespread in the genome and greatly exceeds the influence of imprinting on genome-wide methylation patterns."
- 2.) Fraser:"Population-specificity of human DNA methylation"
- Fraser:" Here we measure DNA methylation near the transcription start sites of over 14, 000 genes in 180 cell lines
- derived from one African and one European population. We find population-specific patterns of DNA methylation
- at over a third of all genes. Furthermore, although the methylation at over a thousand CpG sites is heritable, these
- heritabilities also differ between populations, suggesting extensive divergence in the genetic control of DNA
- methylation. In support of this, genetic mapping of DNA methylation reveals that most of the population
- specificity can be explained by divergence in allele frequencies between populations, and that there is little overlap
- in genetic associations between populations. These population-specific genetic associations are supported by the
- patterns of DNA methylation in several hundred brain samples, suggesting that they hold in vivo and across
- tissues."
- NEW TOPIC
- SUBJECT MATTER: RACE MIXING AND HEALTH
- 1.) Manuck:" Racial and ethnic differences in preterm birth: A complex,multifactorial problem"
- "Preterm birthremainstheleadingcauseofmorbidityandmortalityamongnonanomalous
- neonates, andisamajorpublichealthproblem.Non-Hispanicblackwomenhavea2-fold
- greater riskforpretermbirthcomparedwithnon-Hispanicwhiterace.Thereasonsforthis
- disparity arepoorlyunderstoodandcannotbeexplainedsolelybysociodemographic
- factors. Underlyingfactorsincludingacomplexinteractionbetweenmaternal,paternal,
- and fetalgenetics,epigenetics,themicrobiome,andthesesociodemographicriskfactors
- likely underliesthedifferencesbetweenracialgroups,buttheserelationshipsarecurrently
- poorly understood.Thisarticlereviewstheepidemiologyofdisparitiesinpretermbirth
- rates andadversepregnancyoutcomesanddiscusspossibleexplanationsfortheracialand
- ethnic differences,whileexaminingpotentialsolutionstothismajorpublichealth
- problem."
- RETYPE: "Preterm birth remains the leading cause of morbidity and mortality among nonanomalous neonates, and is a major public health problem. Non-Hispanic black women have a 2-fold greater risk for preterm birth compared with non-Hispanic white race. The reasons for this disparity are poorly understood and cannot be explained solely by sociodemographic factors. Underlying factors including a complex interaction between maternal, paternal, and fetal genetics, epigenetics, the microbiome, and these sociodemographic risk factors likely underlies the differences between racial groups, but these relationships are currently poorly understood. This article reviews the epidemiology of disparities in preterm birth rates and adverse pregnancy outcomes and discuss possible explanations for the racial and ethnic differences, while examining potential solutions to this major public health problem."
- Future Topics: predictive power of hereditarianism versus egalitarianism
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