The first, and probably most important, "tip" is to not ragequit when you lose a Pokemon. It is extremely frustrating to have the Starly you just grinded die to a back to back critical hit, but its just part of the game. To avoid this, if you're doing a run where items are allowed, try to use a Potion before you are in KO range of a critical hit. This may be hard to maintain, but you won't be sorry when you see that critical hit happen right on the turn you use that Potion. The bottom line is, critical hits are <b>EXTREMELY</b> common when they hurt the most, and it is most likely statistically impossible to go through an entire playthrough without seeing at least a few. Don't always rely on hanging just above the KO range for non-critical hits. One thing that can facilitate easy healing is death fodder. These Pokemon are your friends and you should bond with them, but useless Bidoof #3, lovingly nicknamed Blarajan, can be used as death fodder to allow you to heal your starter if you desperately need it. For instance, on a given Gym you probably won't need all 6 (or 5) of your main party. If you have an excess of boxed Pokemon that would need to be grinded a lot to even think about being useful, you may wish to box a few of your main Pokemon to allow for 1-2 death fodder Pokemon. This may seem against the idea of Nuzlocke, but if something has to take a hit for the team, better off it being a Bidoof than your starter. Speaking of Bidoof, make sure to have a decent HM slave at all times. It would really suck to get to Victory Road, and then not have any Pokemon who can learn Waterfall or the like. You will almost always have a Pokemon that can learn a needed HM, but just something to keep at the back of your mind as you play.

This tip does not apply to BW games, but Gyarados is very powerful. The Old Rod is easily obtained early on, and you can usually find a water body in a town. This means that Magikarp is 100% obtainable (unless you are extremely unlucky). Once Magikarp evolves, Gyarados will help tremendously with its raw power, great bulk, and Intimidate. This, coupled with the fact that Electric-type attacks are not very common in the game, make Gyarados a star player in any Nuzlocke run.