documentclass[a4paper, 12pt]{article}
usepackage[top=1in, bottom=1in, left=1in, right=1in]{geometry}
usepackage{ucs}
usepackage{graphicx}
usepackage{float}
usepackage{mathptmx}
usepackage{setspace}
usepackage{anyfontsize}
usepackage[sorting=none]{biblatex}
usepackage{t1enc}
usepackage[utf8x]{inputenc}
usepackage{culmus}
usepackage[english,hebrew]{babel}

addbibresource{Bib.bib}

begin{document}


L{huge{hello hello}}
end{spacing}

medskip
Large{שלום}

section{References:}}
printbibliography[heading=none]

end{document}

Incompatible package 'ucs'. See the biblatex package.

documentclass[a4paper, 12pt]{article}
usepackage[T1]{fontenc}
usepackage[utf8]{inputenc}
usepackage{culmus}
usepackage[english,hebrew]{babel}

pdfmapfile{=culmus.map}

DeclareUnicodeCharacter{05E9}{hebshin}
DeclareUnicodeCharacter{05DC}{heblamed}
DeclareUnicodeCharacter{05D5}{hebvav}
DeclareUnicodeCharacter{05DD}{hebfinalmem}
% and more

begin{document}


Large{שלום}


end{document}