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- Удобный информативный FAQ пастбин на английском.
- https://pastebin.com/raw/jeDsZPGd
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- Симптомы
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243791/
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- ДЕСЯТЬ ГЛАВНЫХ НЕ ОТВЕЧЕННЫХ ВОПРОСОВ О SARS2
- The 2019 human coronavirus: Ten areas of uncertainty waiting to be resolved
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235473/
- http://archive.is/eCjTY
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- ОТЧЕТ ВОЗ и КНР В КОТОРОМ ТРЕБУЮТ ПРИЗНАТЬ ВИРУС ОПАСНЫМ
- https://www.rosminzdrav.ru/news/2020/03/04/13469-predstavlen-otchet-o-rabote-mezhdunarodnoy-missii-voz-po-probleme-covid-19
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- СПОСОБЫ ПЕРЕДАЧИ/AIRBORNE/AEROSOLIZATION/FOMITE
- Identifying airborne transmission as the dominant route for the spread of COVID-19
- https://www.pnas.org/content/early/2020/06/10/2009637117
- Stability of SARS-CoV-2 in different environmental conditions
- https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(20)30003-3/fulltext#sec1
- SARS2 and airborne transmissions*
- https://www.sciencedirect.com/science/article/pii/S2590252020300143
- http://archive.is/JsXmN
- Evoporated SARS2 droplets on surfaces
- https://arxiv.org/abs/2005.12262
- http://archive.is/F5Mcy
- Fomite transmissions of SARS2
- https://arxiv.org/abs/2005.11443
- http://archive.is/lexYG
- Surface and air contamination of SARS2
- https://www.medrxiv.org/content/10.1101/2020.05.24.20110346v1
- http://archive.is/pCYen
- SARS2 can travel up to 100 meters
- https://www.researchhub.com/paper/817121/summary
- http://archive.is/tv1JO
- Particulate matter (PM2.5) as a potential SARS-CoV-2 carrier
- >Herein, we report the involvement of fine indoor air particulate with the diameter of ≤ 2.5 µm (PM2.5) as the transport agent of the virus. PM2.5 was collected over four weeks during a 48 hours measurement intervals in four separate wards containing different infected clusters in a teaching hospital in Kuala Lumpur, Malaysia. Our results indicated highest SARS-CoV-2 RNA on PM2.5 in the ward associated with a lavatory.
- https://www.researchsquare.com/article/rs-33354/v1
- [b]Исследование продолжительности жизни вируса вне носителя(до 3х часов в воздухе, 24х часов на картоне и 2-3 дней на пластике и стали[/b]
- >We found that viable virus could be detected in aerosols up to 3 hours post aerosolization, up to 4 hours on copper, up to 24 hours on cardboard and up to 2-3 days on plastic and stainless steel
- https://www.medrxiv.org/content/10.1101/2020.03.09.20033217v1.full.pdf
- Распространяется через фекалии и их запахи - твёрдо и четко
- https://wwwnc.cdc.gov/eid/article/26/8/20-0681_article
- Risk of SARS-CoV-2 infection from contaminated water systems
- >We identify that the virus can remain stable within water for up to 25 days
- https://www.medrxiv.org/content/10.1101/2020.06.17.20133504v1
- Лифт и бессимптомный носитель
- Large SARS-CoV-2 Outbreak Caused by Asymptomatic Traveler, China
- https://wwwnc.cdc.gov/eid/article/26/9/20-1798_article
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- Мелотанин и разная эксперементальная терапия
- Therapeutic Algorithm for Use of Melatonin in Patients With COVID-19
- https://www.frontiersin.org/articles/10.3389/fmed.2020.00226/full
- Melatonin is a dynamic immunological treatment*
- http://archive.is/qD8Ml
- Zinc iodide as a treament for SARS2*
- https://www.sciencedirect.com/science/article/pii/S030698772030503X
- http://archive.is/6IeGp
- Medications to increase/decrease ACE2 expression
- http://archive.is/V4bUp
- https://www.medrxiv.org/content/10.1101/2020.05.25.20100438v1
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- Маски нужны:
- https://www.ncbi.nlm.nih.gov/pubmed/32064854
- https://jamanetwork.com/journals/jama/fullarticle/184819
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- ВСЕ ПРИНИМАВШИЕ АРБИДОЛ УМЕРЛИ НАХУЙ, КЛИНИЧЕСКОЕ ИССЛЕДОВАНИЕ
- https://www.medrxiv.org/content/10.1101/2020.02.17.20024166v3.full.pdf
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- Курильщики подвержены вирусу сильнее
- https://www.medrxiv.org/content/10.1101/2020.02.05.20020107v1
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- Potential influence of Coronavirus/ACE2 on the female reproductive system
- https://academic.oup.com/molehr/advance-article/doi/10.1093/molehr/gaaa030/5828941
- У переболевших COVID-19 наблюдаются проблемы с почками и репродуктивной системой, как следствие - бесплодность
- https://www.medrxiv.org/content/10.1101/2020.02.12.20022418v1.full.pdf
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- Индекс распространения между 6.11 и 8.18, выше чем ожидалось
- https://archive.is/1WTiA
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- [b]Слитая презентация для госпиталей США по подготовке к эпидемии. 98 миллионов зараженных в США, 480к смертей:[/b]
- [b]http://archive.is/9wLaw[/b]
- Ссылка на PDF https://gofile.io/?c=NDDHhj
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- COVID19 - Летающий спидорак, теперь оффициально.
- https://www.globaltimes.cn/content/1181121.shtml
- [b]Иммунная система идёт по пизде от covid19, воздушный СПИДОРАК официально[/b]
- https://www.nature.com/articles/s41423-020-0424-9
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- COVID-19-associated invasive pulmonary aspergillosis
- https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00686-4
- http://archive.is/zT5JF
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- Животные
- Animal-to-human transmission confirmed
- https://www.biorxiv.org/content/10.1101/2020.05.18.101493v1
- http://archive.is/T85H3
- https://newsroom.wcs.org/News-Releases/articleType/ArticleView/articleId/14010/A-Tiger-at-Bronx-Zoo-Tests-Positive-for-COVID-19-The-Tiger-and-the-Zoos-Other-Cats-Are-Doing-Well-at-This-Time.aspx
- https://www.biorxiv.org/content/10.1101/2020.04.01.021196v1.full.pdf
- Возможные рекомбинации в популяции животных
- Sewage of human waste is spreading the virus to wildlife near the treatment plants including bats, who can mix Coronachan with other coronavirus and then pass it back to humans more lethal than before. Beware sewage leaks near you.
- The study:
- https://www.sciencedirect.com/science/article/pii/S0048969720328758
- >This proposed model is premised on transmission of SARS-CoV-2 from human feces through municipal waste water treatment plants into the natural aquatic environment where potential wildlife hosts become infected.
- >Although we focus on North America, our conceptual model could apply to other parts of the globe as well.(remember Brazilian bat anon?)
- >We believe the existing evidence also supports the plausibility of novel coronaviruses, such as SARS-CoV-2, spilling over to new wildlife hosts through fecal shedding by infected humans and introduction to the natural aquatic environment via the waste water treatment system. Such scrutiny could integrate surveillance of key wildlife species, such as bats and raccoons, which have the potential for acquiring coronaviruses from their aquatic environments.
- Brace for recombination events
- >However, bats remain the most likely species where spillover of SARS-CoV-2 might occur. Bats drink directly from natural water sources, such as lakes, ponds and slow-flowing streams and rivers, by swooping over the water sources and lapping at the surface.
- >Of particular concern, is whether there is the potential for recombination of SARS-CoV-2 with other bat coronaviruses should spillover of SARS-CoV-2 occur in bat populations.
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- [b]1 out of 4 SARS2 patients had kidney failure[/b]
- https://www.medrxiv.org/content/10.1101/2020.05.08.20096040v1
- Исследование с помощью уриноанализа показало что коронавирус может нанести урон почкам.
- https://www.medrxiv.org/content/10.1101/2020.04.03.20051722v1
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- Pulmonary Thromboembolic Disease in Patients with COVID-19 Undergoing Computed Tomography Pulmonary Angiography (CTPA): Incidence and Relationship with Pulmonary Parenchymal Abnormalities
- >The concomitant presence of fibrotic features on CT indicates the need for follow-up for evaluation of CHRONIC pulmonary complications.
- https://www.medrxiv.org/content/10.1101/2020.06.01.20118505v1
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- FDG PET/CT scan reveals hypoactive orbitofrontal cortex in anosmia of COVID-19
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196385/
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- Systemic Effects of Missense Mutations on SARS-CoV-2 Spike Glycoprotein Stability and Receptor Binding Affinity
- https://www.biorxiv.org/content/10.1101/2020.05.21.109835v1.full.pdf
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- The MERS-CoV receptor DPP4 as a candidate binding target of the SARS-CoV-2 spike
- https://www.sciencedirect.com/science/article/pii/S258900422030345X
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- ORF3c gene isolated and emerged with G614 mutation
- A previously uncharacterized gene in SARS-CoV-2 illuminates the functional dynamics and evolutionary origins of the COVID-19 pandemic
- https://www.biorxiv.org/content/10.1101/2020.05.21.109280v1
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- An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations
- SARS2 "superantigen" insertion never seen in SARS CoV
- http://archive.is/G6fEO
- https://www.biorxiv.org/content/10.1101/2020.05.21.109272v1
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- Overall, the data indicates that SARSCoV2 is uniquely adapted to infect humans, raising questions of its origin
- https://arxiv.org/abs/2005.06199
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- Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
- https://www.biorxiv.org/content/10.1101/2020.06.17.157982v1
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- Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
- https://www.nature.com/articles/s41577-020-0331-4
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- SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
- >spike protein’s furin cleavage site is identical to a sequence in the human epithelial sodium channel, which likewise must be cut by furin in order to be activated
- https://archive.is/PxPpi
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- Новый опасный штамм в Индии
- https://www.deccanchronicle.com/science/science/040620/ccmb-clalims-discovery-of-more-virulent-strain-of-covid-19-virus-in-in.html
- https://www.biorxiv.org/content/10.1101/2020.05.31.126136v1
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- Thrombotic Neurovascular Disease in COVID-19 Patients
- >Patients with signs of stroke were delaying coming to the hospital for fear of getting the coronavirus. There's a small window of time in which strokes are treatable, so delays can be life threatening.
- >The mortality rate in covid-19 stroke patients is 42.8%. The typical mortality from stroke is around 5 to 10%.
- >42% of the stroke coronavirus positive patients studied were under the age of 50. Most strokes, over 75% of all strokes in the US, occur in people over the age of 65.
- >The incidence of coronavirus in the stroke population was 31.5%, according to this sample of patients.
- >Patients observed had stroke in large vessels, in both hemispheres of the brain, and in both arteries and veins of the brain - all of these observations are unusual in stroke patients.
- http://archive.is/FjWbJ
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- Иммунитет? Нет.
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- Реинфекции confirmed.
- COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing
- https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1275/5897019
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- Coronavirus protective immunity is short-lasting
- https://www.medrxiv.org/content/10.1101/2020.05.11.20086439v2
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- Spain's coronavirus antibodies study adds evidence against herd immunity
- https://edition.cnn.com/2020/07/06/health/spain-coronavirus-antibody-study-lancet-intl/index.html
- >Spain's large-scale study on the coronavirus indicates just 5% of its population has developed antibodies, strengthening evidence that a so-called herd immunity to Covid-19 is "unachievable," the medical journal the Lancet reported on Monday.
- >The findings show that 95% of Spain's population remains susceptible to the virus. Herd immunity is achieved when enough of a population has become infected with a virus or bacteria -- or vaccinated against it -- to stop its circulation.
- https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31483-5/fulltext
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- Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
- https://www.biorxiv.org/content/10.1101/2020.07.13.190140v1
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- ADE - antibody-dependent enhancement, - Антителозависимое усиление инфекции
- Coronavirus vaccine developers wary of errant antibodies
- https://www.nature.com/articles/d41587-020-00016-w
- Paradoxical dynamics of SARS-CoV-2 by herd immunity and ADE
- https://www.cambridge.org/engage/coe/article-details/5ead2b518d7bf7001951c5a5
- Evidence for SARS2 ADE (peer reviewed)
- https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30702-6#%20
- http://archive.is/26p4J
- Immunity after COVID-19: protection or sensitization ?
- https://www.medrxiv.org/content/10.1101/2020.05.21.20108860v1
- Genomic ADE research
- https://www.cambridge.org/core/services/aop-cambridge-core/content/view/504FE38E2475590EFE93872BC6D67D3D/S2059866120000394a.pdf
- Mistaken assumptions about SARS-CoV-2's aetiology risk creating ineffective or actively harmful vaccines, including the risk of Antibody-Dependent Enhancement (ADE). Such problems in vaccine design are illustrated from past experience in the HIV domain. We propose that the dual effect general method of action of this chimeric virus’s spike, including receptor binding domain, includes membrane components other than the ACE2 receptor, which explains clinical evidence of its infectivity and pathogenicity
- https://www.cambridge.org/core/services/aop-cambridge-core/content/view/DBBC0FA6E3763B0067CAAD8F3363E527/S2633289220000083a.pdf/biovacc19_a_candidate_vaccine_for_covid19_sarscov2_developed_from_analysis_of_its_general_method_of_action_for_infectivity.pdf
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- Immune evasion via SARS-CoV-2 ORF8 protein
- The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I
- Viral infection would elicit effective innate and adoptive immune response to inhibit the viral replication. Apparently, the anti-viral immunity on SARS-CoV-2 infection remains largely unknown. A proportion of recovered patients still exhibit as the virus carriers and the case of CD8+ lymphocytes dysfunction was reported
- These clinical characters of COVID-19 suggest that SARS-Cov2 could lead to adoptive immune disorder while remain active viral replication. In this report, we have demonstrated that SARS-CoV-2 ORF8 mediates MHC-I downregulation, which is not observed in any other strains of SARS-CoV. The discrepancy of ORF8 between SARS-CoV-2 and SARS-CoV could at least partially be responsible for specific COVID-19 clinical and pathological characteristics, which somehow behaves as a chronic viral infection.
- https://www.biorxiv.org/content/10.1101/2020.05.24.111823v1
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- >Dengue Fever, COVID ‐19 (SARS‐CoV ‐2), and Antibody‐Dependent Enhancement (ADE ): A Perspective
- Here, we review the possible antibody‐dependent enhancement (ADE) occurrence, known for dengue infections, when there is a second infection with a different virus strain. Consequently, preexisting antibodies do not neutralize infection, but enhance it, possibly by triggering Fcγ receptor‐mediated virus uptake. No clinical data exist indicating such mechanism for SARS‐CoV‐2, but previous coronavirus infections or infection of SARS‐CoV‐2 convalescent with different SARS‐CoV‐2 strains could promote ADE, as experimentally shown for antibodies against the MERS‐CoV or SARS‐CoV spike S protein.
- https://onlinelibrary.wiley.com/doi/full/10.1002/cyto.a.24047
- http://archive.is/oeoyA
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- Implications of antibody-dependent enhancement of infection for SARS-CoV-2 countermeasures
- >Here, we highlight clinical and experimental observations from earlier CoV outbreaks and suggest strategies that may reduce ADE in treating the SARS-CoV-2 pandemic. Whether SARS-CoV-2 can cause ADE effects remains an open question.
- >Epidemiological studies investigating ADE in individuals with multiple SARS-CoV-2 infections or cross-reactivity to common-cold-causing CoVs will likely take several years. However, given that ADE has been observed with the closely related SARS-CoV, we believe that the question of ADE effects in SARS-CoV-2 should be urgently resolved using experimental immunology.
- >As a cautionary note, no effort has yet been able to identify epitopes that can fully avoid the problem of ADE for any single viral pathogen associated with the phenomenon.
- https://www.nature.com/articles/s41587-020-0577-1
- http://archive.is/gVLtJ
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- Individuals infected with earlier SARS-CoV-2 coronavirus strains could be defenseless against more aggressive European strains with the D614G mutations.
- >Antibodies found in blood of individuals who have fought the disease previously failed to stop the D614G strain.
- >The mutant form was collected from Beijing's current outbreak
- >Dr Ailong said that there is an urgent need to determine what threat this mutation poses to people who have recovered from a different form of the virus. Also worrisome is that the new strain could actually be more worse the second time round in patients who were previously infected with the milder strains and recovered
- >The strain with the D614G mutation began spreading in Europe in early Feb and by May was the dominant strain around the world, presenting in 70% of sequenced samples in Europe and North America. It is now in India, Iran, Middle-East and Brazil
- >12% of the newly infected in Beijing are in critical condition
- >Virus was found in the mouths of imported salmon among other places.
- >Dr Huang and his team selected a strain of the virus that had previously circulated China and manipulated it to create a man-made version containing the mutation
- >They extracted antibodies from 41 blood samples from recovered patients and pitched them against the mutant. All failed to fight the new strain.
- >San Diego report reveals D614G mutation has the potential to increase the number of spike proteins on the coronavirus and boost its ability to infect human cells by a factor of 10.
- >1 of the concerns now is whether the mutated D614G strain will devastate vaccine development since the current vaccines reaching final trials are based on the Wuhan strain.D614G mutation could reduce the effectiveness of vaccines that target the virus’ spike protein
- >It must be noted that here are also other strains with mutations on them being discovered, with another 2 more that might be even more potent.
- https://www.thailandmedical.news/news/warning-d614g-mutation-coronavirus-strains-from-europe-could-render-those-recovered-from-earlier-strains-defenseless-according-to-china
- The D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity and decreases neutralization sensitivity to individual convalescent sera
- https://www.biorxiv.org/content/10.1101/2020.06.20.161323v1
- https://archive.is/gRm6C
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- Антитела - недолговременные
- Prevalence of IgG antibodies to SARS-CoV-2 in Wuhan - implications for the ability to produce long-lasting protective antibodies against SARS-CoV-2
- https://www.medrxiv.org/content/10.1101/2020.06.13.20130252v1
- There may be no immunity against Covid-19, new Wuhan study suggests
- https://www.scmp.com/news/china/science/article/3089476/there-may-be-no-immunity-against-covid-19-new-wuhan-study
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- Viral reactivation in Italian patient
- http://archive.is/NTHMj
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- Sailors on Sidelined Carrier Get Virus for Second Time
- http://archive.is/1izfx
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- Re-infected patients had low protective antibodies
- http://archive.is/2ZqJP
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- Coronaviruses and re-infections overview
- http://archive.is/zLZNY
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- Case study of SARS2/influenza co-infected patient
- http://archive.is/vSjms
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- Иммунитет выживших сильно ослаблен
- https://archive.is/2EQ6x
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- SARS2 and co-infections*
- http://archive.is/OGgqg
- https://www.sciencedirect.com/science/article/pii/S1684118220301274
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- Reactivation/chronic illness from SARS-CoV2
- The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I
- https://www.biorxiv.org/content/10.1101/2020.05.24.111823v1
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- ТЕСТЫ - ХУЙНЯ
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- https://archive.is/mJOrA (Nature)
- also https://covid19testingkits.org/wp-content/uploads/2020/04/Product-Insert-B21888-01-COVID-19-IgG-IgM.pdf
- >Positive results may be due to past or present infection with non-SARS-CoV-2 coronavirus strains
- Antibody tests vastly underperform advertised accuracy
- https://archive.is/MGJrW
- https://www.medrxiv.org/content/10.1101/2020.04.15.20066407v1.full.pdf
- New antigen tests are inaccurate
- https://www.sciencemag.org/news/2020/05/coronavirus-antigen-tests-quick-and-cheap-too-often-wrong
- http://archive.is/a2QBG
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- Вакцины терпят крах
- Oxford vaccine doesn't prevent infections (op-ed)
- https://blogs.sciencemag.org/pipeline/archives/2020/05/18/criticism-of-the-oxford-coronavirus-vaccine
- Harvard Prof: Oxford vaccine is ineffective
- https://www.forbes.com/sites/williamhaseltine/2020/05/16/did-the-oxford-covid-vaccine-work-in-monkeys-not-really/#3f3c240a3c71
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- ЦНС и мозг
- https://pastebin.com/raw/6wGeMfrG
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- RESOURCES FOR NEUROLOGICAL COMPLICATIONS/SYMPTOMS IN COVID-19
- https://www.ean.org/ean/eancore-covid-19
- https://braininfectionsglobal.tghn.org/covid-neurology-resource/
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- Пруфы нейротоксичности вируса
- http://archive.is/byMqw
- https://www.preprints.org/manuscript/202005.0365/v1
- https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.25728
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- Spectrum of neurological manifestations associated with SARS-CoV-2 infection
- Can lead to:
- >Acute Encephalopathy
- >Seizures / Status Epilepticus
- >Acute Hemorrhagic Necrotizing Encephalopathy
- >Ischemic Stroke / Intra Cerebral Hemorrhage / Cerebral Venous Sinus Thrombosis
- >Encephalitis
- >Demyelinating lesions
- >Guillain-Barré Syndrome / Miller Fisher Syndrome
- >Posterior Reversible Encephalopathy Syndrome
- >Subjective neurological symptoms
- https://ictalgroup.org/2020/04/08/spectrum-of-neurological-manifestations-associated-with-sars-cov-2-infections/
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- SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects
- https://www.biorxiv.org/content/10.1101/2020.05.20.106575v1
- http://archive.li/CjHEa
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- ПОВРЕЖДЕНИЯ/ИНФИЦИРОВАНИЕ ЦНС
- SARS2 and the nervous system
- http://archive.is/K64wc
- https://link.springer.com/article/10.1007/s13365-020-00840-5
- COVID-19: A Systematic Review of The Mechanisms of Injury to The Central Nervous System This Far
- 2019-nCoV has an alarming potential to affect the nervous system, and to cause serious illnesses such as seizures, hemorrhagic or ischemic strokes, encephalitis, meningitis, Guillain-Barré Syndrome, and many others.
- There is strong evidence supporting the link between 2019-nCoV and nervous damage, and that there are at least three means by which it may directly enter the CNS, and three by which it may cause indirect harm to the CNS
- https://iajmh.emnuvens.com.br/iajmh/article/view/115
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- There's two ways the virus appears to enter the CNS, through the olfactory nerve and through BBB breakdown. The olfactory route is the mechanism behind common early symptoms like anosmia.
- >Once SARS-CoV-2 reaches the olfactory bulb, it may target the deeper parts of the brain including the thalamus and brainstem by trans-synaptic transfer as described for many viral disease
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192347/
- But BBB breakdown is associated with acute systemic inflammation
- >the intense systemic inflammatory response linked to viral infection can lead to blood–brain barrier (BBB) breakdown. This in turn can allow peripheral cytokines to gain access to the CNS, where they may trigger or exacerbate neuroinflammation leading to encephalitis
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172664/
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- [b]Coronavirus: Neuropsychiatric symptoms and immunologic mechanisms[/b]
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152874/
- https://www.frontiersin.org/articles/10.3389/fneur.2020.00498/abstract
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- SARS2 is "neurotoxin-like"
- http://archive.is/QKJc8
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- SARS-CoV-2 can induce brain and spine demyelinating lesions
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197630/
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- Review of neurological conditions
- http://archive.is/fm94T
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- Neuroradiological features in coronavirus patients: first evidence in a complex scenario
- http://archive.is/TlxB3
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- SARS2 enters neurons within 2 days of infections, neurodegenerative
- http://archive.is/CjHEa]
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- Loss of taste/smell fourth most common symptom
- http://archive.is/8Ii0r
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- Taste disorders present in half of SARS2 cases
- https://www.gastrojournal.org/article/S0016-5085(20)30595-3/fulltext
- http://archive.is/lyuHN
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- Meningoencephalitis Without Respiratory Failure in a Young Female Patient With COVID-19 Infection in Downtown Los Angeles
- https://pubmed.ncbi.nlm.nih.gov/32305574/
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- Continuous Electroencephalography (cEEG) Characteristics and Acute Symptomatic Seizures in COVID-19 Patients
- https://www.medrxiv.org/content/10.1101/2020.05.26.20114033v1
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- Стволовые клетки
- Lung epithelial stem cells express SARS-CoV-2 entry factors: implications for COVID-19
- https://www.biorxiv.org/content/10.1101/2020.05.23.107334v1
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- Neuropilin-1 is a host factor for SARS-CoV-2 infection
- https://www.biorxiv.org/content/10.1101/2020.06.05.134114v1
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- Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system
- https://www.biorxiv.org/content/10.1101/2020.06.07.137802v1
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- Neutrophils maybe causing viral sepsis and MIS-C
- http://archive.is/HfadL
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- Reactivation/neurodamage of SARS2 mirrors Nipah virus
- http://archive.is/p6nOm
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- Brainstem involvement in fatal SARS2 cases
- http://archive.is/Q46iL
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- Longterm neurological consequences of SARS2
- http://archive.is/6cwbT
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- Review: neuropsychiatric aspects of SARS2
- http://archive.is/2wBXi
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- 31/71 patients experienced SARS2 delirium
- http://archive.is/pqkl4
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- Encephalopathy in SARS2, no BBB cross
- http://archive.is/EWP6e
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- Ischemic brain damage in SARS2 patients
- http://archive.is/UALgD
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- ICUs Become A ‘Delirium Factory’ For COVID-19 Patients
- >Although COVID-19 is best known for damaging the lungs, it also increases the risk of life-threatening brain injuries — from mental confusion to hallucinations, seizures, coma, stroke and paralysis. The virus may invade the brain, as well as starve the organ of oxygen by damaging the lungs. To fight the infection, the immune system sometimes overreacts, battering the brain and other organs it normally protects.
- >Some of the best-known symptoms of COVID-19 might be caused by the virus invading the brain, said Dr. Robert Stevens, an associate professor of anesthesiology and critical care medicine at Johns Hopkins University.
- >Many COVID patients develop “silent hypoxia,” in which they are unaware that their oxygen levels have plummeted dangerously low, Stevens added. When hypoxia occurs, regulatory centers in the brain stem — which control respiration — signal to the diaphragm and the muscles of the chest wall to work harder and faster to get more oxygen into the body and force out more carbon dioxide, Stevens said. The lack of this response in some patients with COVID-19 could indicate the brain stem is impaired.
- http://archive.is/K0Nqz
- --------------------------------------------------------------------------------------------------------------------------------
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- Critically ill SARS-CoV-2 patients display lupus-like hallmarks of extrafollicular B cell activation
- http://archive.li/5JiBd
- >permanent lung damage?
- >SARS-Cov2 enables anaerobic bacteria (Prevotella, et al) to colonize the lungs disrupting homeostasis - symptoms (ARDS, septic shock, blood clots, arterial stroke) finds resonance, with key differences, in the ‘forgotten disease’ Lemierre Syndrome
- osf.io/usztn/
- >for the first time, SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with coronavirus.
- medrxiv.org/content/10.1101/2020.04.30.20083907v1
- Coronavirus may lurk deep in lungs after patients recover, study suggests
- http://archive.is/AoZZJ
- https://www.medrxiv.org/content/10.1101/2020.03.29.20041962v2
- Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation
- >Actor Nick Cordero struggling to survive Coronachan gave him blood clots that lead to necessary leg amputation, wife says his healthy lungs deteriorated to that of a 50 year old heavy smoker
- goodmorningamerica.com/wellness/story/broadway-star-nick-cordero-holes-lungs-battle-covid-70449370
- >Most who "recovered" haven't actually recovered
- >researchers found mild to significant lung abnormalities on the chest computed tomography (CT) images of 94 percent of patients with coronavirus upon discharge from the hospital, suggesting follow-up monitoring of patients might be necessary.
- itnonline.com/content/study-looks-ct-findings-covid-19-through-recovery
- Coronavirus patient puzzles New York doctors with rare symptoms
- >patient’s lungs indicated a fungal invasion
- >He developed a cytokine storm within a few hours of the disease’s onset, something that rarely happens so quickly
- http://archive.is/LF4oe
- Strokes in young patients 20s-30s rapidly growing
- http://archive.is/MW1SL
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- ГЛАЗА
- CAN SARS2 DAMAGE THE EYES?
- >All patients showed hyper-reflective lesions at the level of ganglion cell and inner plexiform layers more prominently at the papillomacular bundle in both eyes. Ganglion cell and plexiform layer findings could be associated with CNS manifestations that have been described in animal studies and in COVID-19 neurological events
- http://archive.is/mz7gn
- >The ocular implications of human CoV infections have not been widely studied. However, CoVs have been known to cause various ocular infections in animals. Clinical entities such as conjunctivitis, anterior uveitis, retinitis, and optic neuritis have been documented in feline and murine models
- http://archive.is/2sOYQ
- >Across all eye specimens, immunohistochemical analysis revealed expression of ACE2 in the conjunctiva, limbus, and cornea, with especially prominent staining in the superficial conjunctival and corneal epithelial surface. Surgical conjunctival specimens also showed expression of ACE2 in the conjunctival epithelium, especially prominent in the superficial epithelium
- http://archive.is/rhgAq
- >It cannot be excluded that SARS-CoV-2 could both infect the eye and the surrounding structures. SARS-CoV-2 may use ocular structure as an additional transmission route, as demonstrated by the COVID-19 patients’ conjunctival secretion and tears positivity to reverse transcriptase-PCR SARS-CoV-2-RNA assay.
- http://archive.is/wLxe9
- >12 patients had ocular manifestations, such as epiphora, conjunctival congestion, or chemosis, and these commonly occurred in patients with more severe systemic manifestations...more significant changes in blood test values appeared in patients with ocular abnormalities
- http://archive.is/1q5Fn
- >Fifteen (27%) had aggravated ocular symptoms, of which 6 (11%) had prodromal ocular symptoms before disease onset. Ocular symptoms are relatively common in COVID-19 disease and may appear just before the onset of respiratory symptoms
- http://archive.is/yXzA4
- >ACUTE VISION LOSS IN A PATIENT WITH COVID-19
- https://www.medrxiv.org/content/10.1101/2020.06.03.20112540v1
- >Transient cortical blindness in COVID-19
- https://www.jns-journal.com/article/S0022-510X(20)30194-5/pdf
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- Дети.
- Characteristics and Outcomes of Children With Coronavirus
- https://jamanetwork.com/journals/jamapediatrics/fullarticle/2766037
- "Hyperinflammatory shock in children during coronavirus pandemic"
- https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31094-1/fulltext
- >SHOW ME SIGNIFICANT DEATHS OF THE YOUNG AND HEALTHY IN ANY COUNTRY
- Count all the latest kawasaki deaths then
- Outbreak of Kawasaki disease in children during coronavirus pandemic: a prospective observational study in Paris, France
- http://archive.is/Qn3Ne
- --------
- Kawasaki Disease: The Role of Immune Complexes Revisited
- https://www.frontiersin.org/articles/10.3389/fimmu.2019.01156/full
- https://www.ahajournals.org/doi/10.1161/circ.131.suppl_2.54
- Abstract 54: The Correlation Between IgE And The Level Of Interleukin-21 In Kawasaki Disease
- --------
- https://synapse.koreamed.org/search.php?where=aview&id=10.4078/jrd.2013.20.1.4&code=1010JRD&vmode=PUBREADER
- Relation between Kawasaki Disease and Immunoglobulin E
- ---------
- https://www.nature.com/articles/pr2009122
- Molecular Genetics of Kawasaki Disease
- ------------
- https://www.frontiersin.org/articles/10.3389/fped.2019.00018/full
- Causes of Kawasaki Disease—From Past to Present
- -----
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047536/
- >2 Kids and a Teenager dead in New York
- http://archive.is/BN5Dm (CNN, 10/05)
- http://archive.is/fSqVH (RT, 10/05)
- >15 cases in Paris, 70 in New York
- http://archive.is/txKpf (German tagesschau, 14/05)
- >First fatality in France is a 14-year old with no underlying conditions
- http://archive.is/DPSIy (France24, 15/05)
- >Researchers at the Imperial College London early in developing a test
- http://archive.is/VCEQx (FOX, 20/05)
- >Kawasaki-like syndrome now called PMIS (paediatric multisystem inflammatory syndrome) or MIS-C (multisystem inflammatory syndrome in children)
- >20 cases in Bergamo, Italy with Kawasaki symptoms - more than the past 5 years combined
- >Other affected children develop persistent fevers
- http://archive.is/Z4guz (Al-Jazeera, 21/05)
- MIS-C / PMIS / Kawasaki-like syndrome update
- >Symptoms include stomach pains, fever, rashes
- >heart damage all but confirmed
- >Six weeks asymptomatic incubation
- http://archive.is/HssbI (CNN, 20/05)
- >Two cases at Seattle Children's, 13 and 10
- http://archive.is/DRuOy (KIRO7, 22/05)
- >38% of cases have acute kidney injury
- >51% got myocardial impairment
- >75% went into shock
- http://archive.is/9Tg5H (DAIC, 20/05)
- Heart failure in inflammatory syndrome in children in coronavirus pandemic
- http://archive.vn/YngG1
- https://archive.vn/fPgBc
- young adults can also get strange kawasaki like symptoms
- Up to 5 NY Children Dead, 93 Sickened by Rare Coronavirus-Related Illness
- http://archive.is/BERaE
- Children have lower viral loads than adults
- http://archive.is/yP27O
- SARS2: severe childhood disease needing specialist care
- http://archive.is/IiKeK
- >but they're "no worse" than other sick children in specialist hospitals, i.e. cancer patients
- Fatal Central Nervous System Co-Infection with SARS-CoV-2 and Tuberculosis in a Healthy Child
- >The detection of SARS-CoV-2 RNA in cerebellar tissue and the demonstration of seroconversion in IgG and IgA assays was consistent with acute SARS-CoV-2 infection of the central nervous infection. However, the cause of death was brain herniation from her rapidly progressive central nervous system tuberculosis. SARS-CoV-2 may mask or worsen occult tuberculous infection with severe or fatal consequences.
- https://www.researchsquare.com/article/rs-33272/v1
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- Беременные
- Placentas from COVID-19-positive pregnant women show injury
- https://news.northwestern.edu/stories/2020/05/placentas-from-covid-19-positive-pregnant-women-show-injury
- SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with coronavirus.
- medrxiv.org/content/10.1101/2020.04.30.20083907v1
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- Локдауны и меры
- Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe
- https://www.nature.com/articles/s41586-020-2405-7
- The effect of large-scale anti-contagion policies on the COVID-19 pandemic
- https://www.nature.com/articles/s41586-020-2404-8_reference.pdf
- Fear and knowledge of SARS2 by region
- https://www.medrxiv.org/content/10.1101/2020.05.26.20113233v1
- http://archive.is/k07jC
- 55% of US deaths caused by 1-week lockdown delay
- http://archive.is/ECxx5
- Models with linear curves may be wrong
- http://archive.is/RttwF
- Masks & city disinfection needed to slow spread
- http://archive.is/SASx3
- Governance of lockdowns
- http://archive.is/YdC0p
- NY SARS2 higher viral loads than Chicago SARS2
- https://www.medrxiv.org/content/10.1101/2020.05.19.20107144v1
- http://archive.is/iq3t3
- US: biggest clusters NYC, NOLA, Chi
- https://www.medrxiv.org/content/10.1101/2020.05.22.20110155v1
- http://archive.is/labfF
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- Температура и для летомпройдёт шизиков
- No evidence for less transmission above T=26C/80F*
- http://archive.is/tGvA6
- -------------------------------------------------------------------------------------------
- Про заражения до января в Европе и США - их не было.
- The emergence of SARS-CoV-2 in Europe and the US
- >Infections in US and EU didn't happen before Jan
- https://www.biorxiv.org/content/10.1101/2020.05.21.109322v1
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- Смертность
- Observed CFR is dependent on actual testing rate
- http://archive.is/AeX83
- The illusion of confirmed cases
- http://archive.is/dHiT5
- 26% пациентов за пределами Китая умерли
- Peer reviewed
- http://archive.is/Hfqx9
- http://archive.is/MsJBC
- >In the largest-ever study of coronavirus cases outside China, 26% of patients died. Their symptoms came in ‘clusters.’
- https://www.bmj.com/content/369/bmj.m1985
- Sweden: "worst outbreak since Spanish flu"
- http://archive.is/JABnB
- Excess mortality in England at height of SARS2
- https://www.medrxiv.org/content/10.1101/2020.05.26.20113357v1
- http://archive.is/w5QzX
- Факторы риска и группы риска
- A review of risk factors for mortality in SARS2*
- https://onlinelibrary.wiley.com/doi/10.1002/jmv.26050
- US CFR ~4.85%, smoking has no affect on mortality
- http://archive.is/GEC5l
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- SARS2 and the nicotinic cholinergic system
- http://archive.is/H2TqG
- Chromobacterium as broad spectrum anti-virals
- http://archive.is/Az046
- Open data resources for SARS2
- http://archive.is/r4tIP
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- Учёные в говне мочёные.
- https://www.mercurynews.com/2020/05/24/coronavirus-research-stanford-scientists-accused-of-hyping-covid-19-antibody-study/amp/
- >disseminating information about their research, offering it quickly and without filters in the effort to understand and control
- > new communication model is striking at the heart of scientific integrity, publicizing research that has been corrupted by speed, sloppiness and opacity
- >Stanford University, where a trio of researchers are accused of promoting faulty analysis and “tipping the scale” on antibody studies that they say proves the virus is more widespread and less lethal than we feared, and that public health restrictions are too strict
- >Peer review? It’s raucous and transparent, crowdsourced — via email and Twitter — by scores of commentators.
- >more than 10,000 COVID-related papers have been published since January
- >29 studies were published during the 2003 SARS pandemic
- >too much research lacks rigor and responsibility, experts say. Methods aren’t explained; statistical analyses aren’t transparent. Breaking from the usual protocol, testing is rushed into human study before completion of more basic work
- >Treatment trials are using flawed strategies. There is duplication of effort, creating waste
- >tests of the new Moderna vaccine, researchers didn’t wait to see how well it prevents infection in animals before trying it in people and tests involving just eight people, the company revealed very little data about the vaccine’s success
- >“When we do research under pandemic conditions, it is important to maintain the same standard of rigor as we would outside a pandemic,”
- >The nation’s first study of its type, it found that the virus was astoundingly 50 to 85 times more prevalent than presumed. But that meant the death rate was far lower.Yet the project raised eyebrows from the start. Even before they started collecting data, the researchers openly questioned “stay at home” orders.
- http://archive.is/RX9Rc
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- Несортированное
- Sensitivity of antibody assays
- http://archive.is/xiiyG
- http://archive.is/gavvB
- http://archive.is/4ovjC
- Zinc as a prophylactic
- http://archive.is/YCVvM
- Over 1300 introductions of SARS2 into UK
- http://archive.is/KpGPI
- Findings of NYC SARS2-MISC cases
- http://archive.is/raOh9
- Deterioration of SARS2 pts with GI symptoms
- http://archive.is/Gv0oc
- SARS2 pulmonary post-mortem findings
- http://archive.is/FaCi9
- Molecular profile of severe SARS2
- http://archive.is/LRNfi
- Review of myocardial injury in SARS2
- http://archive.is/x7bms
- SARS2 on the male reproductive system
- http://archive.is/ftKXB
- 74% of people moderately to strongly believe SARS2 has lab origins
- http://archive.is/8jXee
- Excess deaths in Italy by region
- http://archive.is/YKkV1
- Viral load infectious regardless of age, symptoms
- http://archive.is/WQ1Es
- High degree of asymptomatic transmission among nurses
- http://archive.is/Wyiz6
- Misinformation, social norms driving icarus effect of SARS2
- http://archive.is/ibedp
- SARS2 "fake news" is endemic to source country
- http://archive.is/uBRWr
- "Fake news" bots tweeting as much as NYT/CDC
- http://archive.is/jSwK9
- G614 mutation neutral to protein function
- http://archive.is/t2bgP
- NETs driving SARS2 sepsis pathologies
- http://archive.is/WGMnJ
- (NETs are thought to enhance hypercoagulation in HIV patients http://archive.is/Gro4C)
- Estimation of global CFR
- http://archive.is/vJtOz
- Case study of negative swab SARS2 patient
- http://archive.is/uyk0f
- Cattle may have been an intermediate host*
- https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25817
- http://archive.is/NkSld
- Second waves over wide range of model scenarios
- http://archive.is/Ti21i
- A2H, H2A, should we be concerned?
- http://archive.is/I9ovC
- Virus lineage in Thailand, truncated ORF7a
- http://archive.is/RXEWf
- https://archive.vn/WcH7Q
- Non lung related symptoms of commie coof a summary
- How SARS2 pandemic has changed pre-print literature
- http://archive.is/SfaV6
- Mechanism for how famotidine fights SARS2
- http://archive.is/qPfzI
- Abnormal liver markers among SARS2 patients
- http://archive.is/iCrhN
- https://archive.vn/josvg
- swedish herd immunity is a long way off if they ever reach it
- https://archive.vn/jwWiT
- france recording 70 new cases of corona after 1 week of reopening schools
- Half of COVID tweets are by misinformation bots
- http://archive.is/vYwob
- SARS2 found in heart, eyes, brain of hACE2 knockout mice
- http://archive.is/dk5Zk
- Call for transparency in SARS2 modelling
- http://archive.is/Gnm11
- Tennessee's 'open test policy' slowing spread
- http://archive.is/tcrON
- Simulation of repurposed drugs for SARS2
- http://archive.is/NjJ6k
- Never seen": COVID hijacks cells, DNA
- http://archive.is/XwTOn
- UK: PPE goes thru 4 levels of profit skimming
- http://archive.is/6joLU
- Canada MD: "Pandemics are never one wave"
- http://archive.is/drMz2
- China launched 90k tweets of disinformation
- http://archive.is/WxWQN
- Brazil new epicenter of global pandemic
- http://archive.is/0PtE2
- 1 out of 4 Americans hesistant about vaccine
- http://archive.is/sx75M
- Delay in lockdowns caused 30k extra US deaths
- http://archive.is/zfi1V
- Jewish doctors treating COVID with marijuana
- http://archive.is/TWhY4
- 80% of infections are caused by 10% of people
- http://archive.is/bWuL7
- China again seizes control of PPE factories
- http://archive.is/3SahP
- Experts: US has 3 months to prepare for 2nd wave
- http://archive.is/AjnXR
- Top HIV scientist says SARS2 vaccine highly unlikely
- http://archive.is/tcH9b
- US meat safety largely unenforced
- http://archive.is/BKJN5
- Half of COVID tweets are by bots
- http://archive.is/TKdLB
- Newborn dies in South Africa
- http://archive.is/iW38v
- 87% of US nurses reusing PPE
- http://archive.is/EItzr
- Cambridge: Online only until summer 2021
- http://archive.is/lEKe3
- Sweden nowhere near herd immunity
- http://archive.is/fdCXI
- CDC is inflating ability to test
- http://archive.is/vDdNJ
- Cloth masks are political not scientific
- http://archive.is/vEFsN
- Italy put COVID patients in nursing homes
- http://archive.is/WiTpK
- Over 122,000 deaths went unreported in 14 countries
- https://archive.is/Qlutx
- Almost all countries only report deaths that occur in hospitals
- https://archive.is/rZp0M
- Hispanics and blacks account for most deaths in California
- https://archive.is/FJAsj
- For coronaviruses, antibodies don't guarantee immunity
- https://archive.is/BV4CI
- Novel coronavirus can survive high temperatures
- https://archive.is/SxQDu
- Italy doesn't report deaths at home and nursing homes
- https://archive.is/zWJw1
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