Pharmaceutical Raw Material Pirfenidone CAS 53179-13-8

High Purity Pharmaceutical Raw Material Pirfenidone CAS 53179-13-8

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Synonyms: 5-methyl-1-phenyl-2(1h)-pyridon;amr-69;PIRFENIDONE;5-METHYL-1-PHENYL-1H-PYRIDIN-2-ONE;5-METHYL-1-PHENYL-2(1H)-PYRIDINONE;5-METHYL-1-PHENYL-2-(1H)-PYRIDONE;5-Methyl-N-phenyl-2-1H-pyridone;Pirfenidone also see 5-Methyl-1-Phenyl-2(1H)-Pyridinone
CAS: 53179-13-8
MF: C12H11NO
MW: 185.22
Purity:99.5%(HPLC)
Solubility:H2O: >10 mg/mL at 60 °C (warming for 30 minutes);DMSO: >20 mg/mL
Chemical Properties Off-White Solid
Usage Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver
Biological Activity Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo . Potent scavenger of free radicals and inhibitor of lipid peroxidation.

Application:
(pirfenidone) is an anti-inflammatory drug used to treat idiopathic pulmonary fibrosis.Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.