Pharma Raw Powder Oxcarbazepine For Anticonvulsant And Treat

Pharma Raw Powder Oxcarbazepine For Anticonvulsant And Treatment Of Epilepsy CAS 28721-07-5

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Oxcarbazepine Description:
Oxcarbazepine is an anticonvulsant drug primarily used in the treatment of epilepsy. There is some evidence for oxcarbazepine as a mood-stabilizing agent and thus, it can be used as add-on therapy for bipolar disorder in patients that have failed or are unable to tolerate approved treatments.

Common side effects include nausea, vomiting, dizziness, drowsiness, headache, double vision and trouble with walking.Although not common, anaphylaxis may occur.Due to its structural similarities to carbamazepine there is approximately a 25-30% chance of cross-reactivity between the two medications.

Oxcarbazepine is marketed as Trileptal by Novartis and available in some countries as a generic drug.There is also an extended-release formulation marketed as Oxtellar XR by Supernus Pharmaceuticals.

Product Name:Oxcarbazepine
Synonyms:10,11-DIHYDRO-10-OXO-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE;10,11-DIHDYRO-10-OXO-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE;5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE, 10,11-DIHYDRO-10-OXO-;TRILEPTAL;f)azepine-5-carboxamide,10,11-dihydro-10-oxo-5h-dibenz(;gp47680;OXCARBAMAZEPINE;OXCARBAZEPINE
CAS:28721-07-5
MF:C15H12N2O2
MW:252.27
EINECS:249-188-8

Product Categories:Heterocyclic Compounds;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents;Heterocycles;Metabolites & Impurities;Pharmaceutical raw material;Chiral Reagents, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;COREG;Other APIs

Melting point:215-216°C
storage temp.: Store at RT
solubility:DMSO: ~9 mg/mL
form:solid
color:white
Water Solubility:Soluble in DMSO, methanol, water, ethanol and acetone.
Chemical Properties:Pale Yellow Powder
Uses:A metabolite of Eslicarbazepine acetate, (BIA 2-093), a novel central nervous system drug.
Uses:beta-adrenergic blocker
Uses:The keto derivative of Carbamazepine. Used as an anticonvulsant


Medical uses

Oxcarbazepine is an anticonvulsant used to reduce the occurrence of epileptic episodes, and is not intended to cure epilepsy.Oxcarbazepine is used alone or in combination with other medications for the treatment of focal (partial) seizures in adults.In pediatric populations, it can be used by itself for the treatment of partial seizures for children 4 years and older, or in combination with other medications for children 2 years and older.

In addition, oxcarbazepine has been shown to improve mood and reduce anxiety; therefore, it is a potential option for add-on therapy in the treatment of bipolar disorder.


Side effects

The most common side effects associated with oxcarbazepine include:
dizziness (6.4%)
blurred or double vision (2.1%)
fatigue (2.1%)
headaches (2.9%)
nausea (4.9%)
vomiting (2%)
sleepiness (2.4%)

there is evidence of difficulty in concentration and mental sluggishness


Other rare side effects of oxcarbazepine include:
severe low blood sodium (1%)
anaphylaxis / angioedema
hypersensitivity (especially if experienced with carbamazepine previously [25-30% cross-reactivity])
toxic epidermal necrolysis (TEN, 0.5 to 6 cases per million-person years)
Stevens-Johnson syndrome (SJS, 0.5 to 6 cases per million-person years)
thoughts of suicide (<1%)

Serum sodium levels should be considered in maintenance treatment or symptoms of hyponatremia develop.Some side effects (such as headache) are more pronounced shortly after a dose is taken and tend to fade with the passage of time (60 to 90 minutes). Other side effects include stomach pain, tremor, rash, diarrhea, constipation, decreased appetite and dry mouth. Photosensitivity is a potential side-effect and people could experience severe sunburns as a result of sun exposure.

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