Ezio and Snake shared a glance before training their weapons at Octopus. Ezio was the first to fire. Though he rarely used handguns, his aim was decent enough for the dart to hit her in the neck. With a broken laugh, she pulled the dart from her neck and tossed it aside. She continued her approach, although she had begun to slow down. Though not slow enough to duck under Snake's shot. Pulling out two new darts, Snake tossed his spare to Ezio as he reloaded. It took the assassin a moment to figure out how to load his shot, though he eventually managed to reload as Snake fired. This time the dart hit her in her shoulder.

Pulling the dart out, Octopus' laugh was fainter, until a dart fired by Ezio hit her in the neck once more. It then became close to a faint chuckle. Another two darts into the guns. Ezio aimed once more, his face stony to hide an inner grimace. Octopus acted as if the fourth dart to hit her neck had not even touched her. Though a fifth dart, piercing her lower neck, caused her to stumble forward and fall face first, unconscious.