import cv2

#TM_SQDIFF_NORMED
method = cv2.TM_SQDIFF_NORMED
small_image = cv2.imread('d2.png', 0) # что ищу
large_image = cv2.imread('d1.png', 0) # где ищу
result = cv2.matchTemplate(small_image, large_image, method)
mn,_,mnLoc,_ = cv2.minMaxLoc(result)
MPx,MPy = mnLoc
trows,tcols = small_image.shape[:2]
cv2.rectangle(large_image, (MPx,MPy),(MPx+tcols,MPy+trows),(0,0,255),10)
res = cv2.resize(large_image, dsize=(2500,2500))
cv2.namedWindow("Resized", cv2.WINDOW_NORMAL)
cv2.imshow("Resized", res)
cv2.waitKey(0)