1. Captain America and / or Iron Man dies.

2. Thor dies or goes away, probably with Asgard.

3. Time Travel is involved

4. Multiverses may be, but at the very least will be mentioned.

5. Highers cosmic powers will be involved or at least mentioned, such as the Living Tribunal.

6. Red Skull will be further involved.

7. Gamora will be revived.

8. Rocket Racoon wil die in this movie or G3.

9. Heimdall (spelling?) was told via time travel to port Hulk probably.

10. Tony's dream is probably more then a dream.

11.