import hashlib, base64

def PackedBase64MD5(fname):
    hash_md5 = hashlib.md5()
    with open(fname, "rb") as f:
        for chunk in iter(lambda: f.read(4096), b""):
            hash_md5.update(chunk)
    Base64Encoded = base64.b64encode(hash_md5.digest())
    UTFencodedStr = str(Base64Encoded , "utf-8")
    return  UTFencodedStr

full_path = r"C:\Tmp\ChanArchiveOutput\brumbrumm.jpg"
print(PackedBase64MD5(full_path))