45  67  Row  Fine
25  22  Abe  Real
58  54  Abe  Noon

58  54  Abe  Noon
25  22  Abe  Real
45  67  Row  Fine

iterable_of_rows = zip(*my_list_of_columns)

import operator
sorted_list_of_rows = sorted(zip(*my_list_of_columns), key = operator.itemgetter(2,3))
list_of_columns = list(zip(*sorted_list_of_rows))

>>> my_list_of_columns = [[45,25,48],[67,22,54],["Row","Abe","Abe"],["Fine","Real","Noon"]]
>>> import operator
>>> sorted_list_of_rows = sorted(zip(*my_list_of_columns), key = operator.itemgetter(2,3))
>>> list_of_columns = list(zip(*sorted_list_of_rows))
>>> list_of_columns
[(48, 25, 45), (54, 22, 67), ('Abe', 'Abe', 'Row'), ('Noon', 'Real', 'Fine')]

>>> print(data)
[[45, 25, 58], [67, 22, 54], ['Row', 'Abe', 'Abe'], ['Fine', 'Real', 'Noon']]

>>> print(sorted(zip(*data), key=lambda x: (x[2], x[3])))
[(58, 54, 'Abe', 'Noon'), (25, 22, 'Abe', 'Real'), (45, 67, 'Row', 'Fine')]