import pandas as pd
import os

filename = 'test.xls'

if os.path.exists(filename):
    os.remove(filename)

df = pd.DataFrame({'Data': [10, 20, 30, 20, 15, 30, 45]})

# Create a Pandas Excel writer using XlsxWriter as the engine.
#writer = pd.ExcelWriter(filename, engine='xlsxwriter')
writer = pd.ExcelWriter(filename,)
print('open', os.path.isfile(filename))

df.to_excel(writer, sheet_name='Sheet1')
writer.save()
print('save', os.path.isfile(filename))