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usepackage{chemfig}
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usepackage[flushleft]{threeparttable}
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usepackage{siunitx}

begin{document}
begin{frame}{Resultados}
begin{table}[H]
centering
begin{adjustbox}{max height=0.3textheight , max width=0.8textwidth}
begin{threeparttable}
caption{Estimación de p$K_text{a}$ para ácidos y alcoholes}label{table:estimacion_pka_RM1}
begin{tabular}{lccccc}
toprule
 & textbf{} & multicolumn{4}{c}{RM1} \  cmidrule(lr){3-6}
 &  & multicolumn{2}{c}{COSMO} & multicolumn{2}{c}{SS-COSMO} \  cmidrule(lr){3-4}cmidrule(lr){5-6}
 & p$Ktext{a}_{text{exp}}$SI{298}{K} & p$Ktext{a}_{text{calc}}$ & $Delta$p$Ktext{a}$ & p$Ktext{a}_{text{calc}}$ & $Delta$p$Ktext{a}$ \  midrule
textbf{Ácidos}&  &  &  &  &  \
acético & 4.75 & 2.1 & 2.6 & 4.2 & 0.6 \
fluoroacético & 2.59 & -0.8 & 3.3 & -0.8 & 3.4 \
fórmico & 3.75 & ref & - & ref & - \
pirúvico & 2.39 & -3.0 & 5.4 & 0.7 & 1.7 \
glioxílico & 3.18 & -2.3 & 5.5 & 0.4 & 2.8 \
propanoico & 4.86 & 2.3 & 2.5 & 3.9 & 0.9 \
butanoico & 4.83 & 2.6 & 2.3 & 4.2 & 0.7 \
acrílico & 4.25 & 2.0 & 2.3 & 1.0 & 3.3 \
láctico & 3.86 & 0.7 & 3.2 & 5.0 & -1.2 \
benzoico & 4.2 & 1.1 & 3.1 & 1.6 & 2.6 \
MAE &  &  & 3.1 &  & 1.8 \  bottomrule
end{tabular}
begin{tablenotes}
footnotesize
item {Comparación de p$Ktext{a}$ calculados con RM1 y dos estrategias de solvatación: implícita (COSMO) y explícita-implícita(SS-COSMO). $Delta$p$Ktext{a}$ =p$Ktext{a}_{text{exp}}$-p$Ktext{a}_{text{calc}}$.}
end{tablenotes}
end{threeparttable}
end{adjustbox}
end{table}
end{frame}

end{document}