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  1. AN EXPLORATION OF “RESEARCH CHEMICALS,” OLD AND NEW,
  2. written by an anonymous dictionary
  3. edit/reformat by roionsteroids of reddit
  4.  
  5. Updates continue as of march 11th, 2014. if anyone has any other citable / reliable sources about any of these compounds or any other new drugs please let me know and i'll try to keep [forum post] updated throughout my hectic life. the document will to continue update here (if possible):
  6.  
  7. https://www.dropbox.com/s/krjln6uxw63zavz/research%20chemicals.rtf
  8.  
  9. Contents:
  10. foreward
  11. a short glossary
  12. I. Stimulants
  13. II. Psychedelic Hallucinogens (Serotonin agonists)
  14. III. Sedatives
  15. IV. Opioid Analgesics
  16. V. Synthetic Cannabinoids
  17. VI. Dissociative Hallucinogens (NMDA antagonists)
  18. VII. Test Kit Results
  19. VIII. References
  20.  
  21. ———————————
  22.  
  23. FOREWARD - some speculation present
  24.  
  25. “A controlled substance analogue shall, to the extent intended for human consumption, be treated, for the purposes of any Federal law as a controlled substance in schedule I.”[44]
  26. - http://www.deadiversion.usdoj.gov/21cfr/21usc/813.htm
  27. Emphasis mine.
  28.  
  29. Over the past 20 years, a plethora of new drugs have appeared, using legal loopholes, to fill the demand for the experiences provided by hallucinogens and stimulants, sedatives and opioids that had been made illegal. These drugs may be slight variations of a drug already scheduled (in the way that 5-MeO-DMT is a slight modification of DMT) or they could be entirely new drugs that happen to have desirable action (such as 7-OH-MIT, an opioid found in the leaves of the kratom tree).
  30.  
  31. How can these drugs be legally made and sold to people? It’s the law:
  32. “(32)(A) Except as provided in subparagraph (C), the term "controlled substance analogue" means a substance—
  33. (i) the chemical structure of which is substantially similar to the chemical structure of a controlled substance in schedule I or II;
  34. (ii) which has a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than the stimulant, depressant, or hallucinogenic effect on the central nervous system of a controlled substance in schedule I or II; or
  35. (iii) with respect to a particular person, which such person represents or intends to have a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than the stimulant, depressant, or hallucinogenic effect on the central nervous system of a controlled substance in schedule I or II.
  36. (B) The designation of gamma butyrolactone or any other chemical as a listed chemical pursuant to paragraph (34) or (35) does not preclude a finding pursuant to subparagraph (A) of this paragraph that the chemical is a controlled substance analogue.
  37. (C) Such term does not include—
  38. (i) a controlled substance;
  39. (ii) any substance for which there is an approved new drug application;
  40. (iii) with respect to a particular person any substance, if an exemption is in effect for investigational use, for that person, under section 355 of this title to the extent conduct with respect to such substance is pursuant to such exemption; or
  41. (iv) any substance to the extent not intended for human consumption before such an exemption takes effect with respect to that substance.”[45]
  42. - http://www.deadiversion.usdoj.gov/21cfr/21usc/802.htm
  43. Emphasis mine.
  44.  
  45. So what does this mean? According to the Federal Analog Act, these designer drugs, with effects equal to (or more powerful than) Schedule I & II, can be sold as long as they are sold in a way that doesn’t suggest human consumption, such as selling it as “incense,” “bath salts,” “potpourri,” “plant food,” or some other innocuous-sounding product.
  46.  
  47. Now, you wouldn’t smoke and inhale incense, you wouldn’t eat bath salts, but that’s how the drug is sold to you. And if you want to try to find out about effects, dosage, or health risks from the vendor who sold it to you, they can’t tell you because doing so implies human consumption. Even if you buy the pure chemical by itself instead of in some blend (usually online, in which case it’s sold as a “research chemical”), you can’t ask the vendor about effects, dosage, or risks. You also can’t be sure of the purity of the drug or if it’s free of contaminants or impurities.
  48.  
  49. The people making or selling the drugs are forbidden to tell the consumers about negative effects. It’s illegal to inform them about the drug, but it’s legal to sell it to them.
  50.  
  51. When you have a large amount of drug consumers who are unable to buy or use illegal drugs (probation, drug testing, or just can’t find any), many of them will find the convenience of legally purchasing a drug at a gas station or having it delivered to their door and still being able to pass their drug tests to be quite alluring. However, the sharing of knowledge about the effects, dosages, and health risks of these hundreds of new drugs that are sold in gas stations across the USA and internet vendors all over the world is illegal because the act of sharing of this information implies human consumption.
  52.  
  53. People are trying these drugs, people are using these drugs, and at least 12 of these people have had acute kidney injury from certain cannabinoids,[36] over 30 people overdosed on heroin adulterated with acetylfentanyl,[12][87] 9 people in Sweden died eating ground kratom leaves adulterated with a Tramadol analogue,[56] 14 more died from a strong stimulant,[8] powerful neurotoxins have been placed in “legal party pills”,[13][17] super-potent hallucinogens have killed 8 people,[7] fentanyl analogs are being used in fake prescription painkillers,[62] and more negative incidents that haven’t been reported. All because the communication of information about the drug that they’re using or even which one it is that they’re using is prohibited.
  54.  
  55. This is happening in a time where naloxone is, as of February 2014, $42 per kit, demand for it is escalating sharply,[73] higher doses of it are needed to combat the stronger opioids now being sold,[74][77] and its accessibility is being delayed by fickle politics.[78]
  56.  
  57. This document is a catalogue of all of the novel psychoactive compounds that I’m aware of, along with as much concrete, citable information I can find about their potency, dosage, and health risks. It is an attempt to communicate this information to medical professionals, to help them treat people suffering from the problems some of these drugs can cause, and to try to prevent people from dying from these drugs.
  58.  
  59. —————
  60.  
  61. A SHORT GLOSSARY
  62.  
  63. RC - research chemical
  64.  
  65. Empathogen - “A class of psychoactive drugs that produce distinctive emotional and social effects similar to those of MDMA[…] users of empathogens say the drugs often produce feelings of empathy, love, and emotional closeness to others.”
  66. - Wikipedia
  67.  
  68. MAOI - Monoamine oxidase inhibitor
  69.  
  70. safeorscam.com - A website that contains a database of vendor names. You enter the website name or email address of the vendor and you'll be able to see reports from other people about the vendor’s quality of service and the quality of their drugs. You can NOT see a list of vendors on this website, you can only find information on vendors whose web address you already know.
  71.  
  72. http://pdsp.med.unc.edu/pdsp.php - Lets you look up chemicals by receptor affinity.
  73.  
  74. http://ecstasydata.org - reveals the contents of street/internet-sourced chemicals, many RCs show up here
  75.  
  76. http://www.dancesafe.org - sells test kits to test MDMA or whatever chemical you have
  77.  
  78. http://bunkpolice.org - same as above
  79.  
  80. If you want further information about any of these chemicals, you can look them up at https://www.erowid.org/psychoactives/psychoactives.shtml,[0] http://www.bluelight.org/, http://reddit.com/r/drugs or http://drugs-forum.com. The forums are full of people testing/enjoying these drugs themselves, so be warned some of them may be unreliable narrators.
  81.  
  82. The use of straight brackets [] represents an information reference, while the use of curly brackets {} represents a picture of test kit results.
  83.  
  84. The drugs described can have several different names. When one is underlined, that is to show the name that is most commonly used to refer to the drug, in speech and in text.
  85.  
  86. I have attempted to note when a drug is particularly desirable for recreation. This is because that while only some of these drugs have many positive effects, even the least desirable drugs appear in incense blends, bath salts and other forms of legal highs.
  87.  
  88. The dosages described are largely from user reports, I err on the side of caution and report the smallest active dose found. I have taken active dosages from PiHKAL,[54] Erowid, and TiHKAL[55] where possible.
  89.  
  90. ——————————
  91.  
  92. I. STIMULANTS/EMPATHOGENS
  93.  
  94. A. Cathinone derivatives - Amphetamines with a ketone group (βk) added to the beta position to create a cathinone version, i.e. Methamphetamine (MA) becomes Methcathinone (βk-MA).
  95.  
  96. 1. Methylone (βk-MDMA, M1, methylenedioxymethcathinone) - Methylone is an empathogen. It has similar activity to MDMA with regards to dopamine and norepinephrine release, but only a third of MDMA's power with regards to serotonin release. Placed in Schedule 1 in October of 2011. Active at 100mg oral. Considered to be recreationally desirable. Test kit results at {2} and {9}.
  97. I. Ethylone (βk-MDEA)
  98. II. Butylone (βk-MBDB) - Illegal as of 2014.[21] Test kit results at {2} and {9}.
  99. III. Eutylone (βk-EBDB)
  100. IV. Dibutylone (βk-DMBDB)
  101.  
  102. 2. Mephedrone (4-methylmethcathinone, 4-MMC, MCAT) – Mephedrone is one of the most popular substituted cathinones, a strong, short-acting stimulant with empathogenic qualities similar to that of MDMA. It is a potent releaser of dopamine, norepinephrine, and serotonin. It has a rather unique danger in one of its metabolites: 4-methylephedrine is a long-acting vasoconstrictor.[28] Placed in Schedule 1. Active at 100mg oral, 50mg intranasal. Considered to be recreationally desirable. activity at NAT, SERT, and DAT can be found at footnote [71]. Test kit results at {2} and {9}.
  103. I. 4-MEC (4-methylethcathinone) - active at 100mg intranasal. Illegal as of 2014.[21] Considered to be recreationally desirable. activity at NAT, SERT, and DAT can be found at footnote [71].
  104. II. 4-EMC (4-ethylmethcathinone) - active at 100mg intranasal.
  105. III. 4-FMC (4-fluoromethcathinone, flephedrone) - Illegal as of 2014.[21] Not considered to be recreationally desirable.
  106. IV. 4-BMC (4-bromomethcathinone, brephedrone) - Illegal as of 2014.[21] Not considered to be recreationally desirable.
  107. V. 3-FMC (3-fluoromethcathinone) - Illegal as of 2014. [21]
  108. VI. 2-FMC (2-fluoromethcathinone)
  109. VII. 3-MeoMC (3-methoxymethcathinone)
  110. VIII. 3-MMC (3-methylmethcathinone) Active at 50mg intranasal. Considered to be recreationally desirable. Unscheduled but very likely considered an analogue of Mephedrone.
  111. IX. Benzedrone (4-BMZ, (±)-1-(4-methylphenyl)-2-(benzylamino)propan-1-one) - activity at NAT, SERT, and DAT can be found at footnote [71].
  112. X. Pentedrone (1-phenyl-2-methylamino-pentan-1-one) - Illegal as of 2014.[21] Not considered to be recreationally desirable.
  113. a. 4-methylpentedrone (4-MPD)
  114. XI. Naphyrone (NRG-1, napthylpyrovalerone) - Illegal as of 2014.[21] Not considered to be recreationally desirable. activity at NAT, SERT, and DAT can be found at footnote [71].
  115. XII. 3,4-DMMC (3,4-dimethylmethcathinone) - Not considered to be recreationally desirable.
  116. XIII. 4-MeMABP (alpha-ethylmephedrone)
  117. XIV. Buphedrone (MABP, α-methylamino-butyrophenone)
  118. XV. Pentylone (1-(1,3-benzodioxol-5-yl)-2-(methylamino)pentan-1-one) - Illegal as of 2014.[21] Not considered to be recreationally desirable.
  119. XVI. NEB (N-Ethylbuphedrone)
  120. XVII. 2-MMC (2-methylmethcathinone)
  121. XVIII. Methedrone (bk-PMMA, 4-methoxymethcathinone) - worthless. see PMMA.
  122.  
  123. 3. Methylenedioxypyrovalerone (MDPV) - Pyrovalerone with a methylenedioxy group attached, MDPV is a potent NDRI. active at 2mg.
  124. I. α-PVP (alpha-pyrrolidinopentiophenone) - Illegal as of 2014.[21]
  125. II. 4-MePPP (4-methyl-alpha-pyrrolidinopentiophenone)
  126. III. MDPPP (3,4-methylenedioxy-alpha-pyrrolidinopentiophenone)
  127. IV. α-PBP (alpha-pyrrolidinobutiophenone) - Illegal as of 2014.[21]
  128. V. DL-4662 (1-(3,4-dimethoxyphenyl)-2-(ethylamino)pentan-1-one)
  129. VI. α-PBT (2-(pyrrolidin-1-yl)-1-(thiophen-2-yl)butan-1-one) - A cathinone with the phenyl ring replaced by the sulfur ring. Pyrovalthiones?
  130. VII. α-PVT (2-(pyrrolidin-1-yl)-1-(thiophen-2-yl)pentan-1-one, alpha-pyrrolidinopentiothiophenone) - Similar to the above, Cathinone with phenyl switched for sulfur ring.
  131. VIII. 4-MeO-PVP (4-methoxy-α-Pyrrolidinovalerophenone)
  132. IX. 4-MeO-PBP (4-methoxy-Pyrrolidinobutrophenone)
  133. X. 4F-PVP (4-fluoro-pyrrolidinopropylphenone) - What is happening with the fluorinated Amphetamines is happening here with Cathinone derivatives too, further down the rabbit hole…
  134. XI. 4-MeO-a-PVP (4-methoxy-α- Pyrrolidinovalerophenone)
  135. XII. 4F-PV8 (4f-α-pyrrolidinoheptiophenone, 1-(4-fluorophenyl)-2-(pyrrolidin-1-yl)heptan-1-one)
  136. XII. 4F-PV9 (1-(4-fluorophenyl)-2-(pyrrolidin-1- yl)octan-1-one)
  137. XIII. PV-4 (4-MPHP, 4’-Methyl-α-pyrrolidinohexiophenone)
  138.  
  139. B. Benzofurans - Phenethylamines with modified methylenedioxy groups, removing one of the two oxygens in the methylenedioxy ring to render a benzofuran ring.
  140. 1. 5-APB (5-(2-aminopropyl)benzofuran), and 6-APB (6-(2-aminopropyl)benzofuran) [aka “Benzo Fury”] - Close analogues of MDA, these two benzofurans are empathogens with some hallucinogenic activity. Created as replacements for Mephedrone and Methylone after they had been scheduled in the UK. active at 100mg oral. Considered to be recreationally desirable. activity at NAT, SERT, and DAT can be found at footnote [71]. Both have high affinity for 5-HT2B.[72] Test kit results for 6-APB can be found at {5}.
  141. 2. 5-APDB (5-(2-aminopropyl)2,3-dihydrobenzofuran)
  142. 3. 6-APDB (6-(2-aminopropyl)2,3-dihydrobenzofuran)
  143. 4. 5-MAPB (5-(2-methylaminopropyl)benzofuran) - Active at 50mg oral. Considered to be recreationally desirable.
  144. 5. 5-MAPDB (5-(2-methylaminopropyl)2,3-dihydrobenzofuran)
  145. 6. 6-MAPDB (6-(2-methylaminopropyl)2,3-dihydrobenzofuran)
  146. 7. 5-EAPB (5-(2-ethylaminopropyl)benzofuran). 5-EAPB has already been responsible for at least one death.[1]
  147.  
  148. C. Phenpropylamines/piperidines
  149. 1. Ethylphenidate - An analogue of Methylphenidate (Ritalin). active at 10mg intranasal, 20mg oral. created by the body when Ritalin is consumed in combination with Alcohol. It is now illegal in the island state of Jersey.[17] Considered to be recreationally desirable.
  150. 2. 2-DPMP (desoxypipradol) - NDRI, a half-life of 16-20 hours and active at 2mg. activity at NAT, SERT, and DAT can be found at footnote [71]. Test kit results at {5}.
  151. 3. 3,4-CTMP (3,4-Dichloromethylphenidate) - Another Methylphenidate analogue, it is active at 5mg. Not considered to be recreationally desirable.
  152. 4. MTTA (Mephtetramine, (2-((methylamino)methyl)-3,4-dihydronaphthalen-1(2H)-one)) - active at 50mg intranasal, 100mg oral.
  153.  
  154. D. Substituted Amphetamines
  155. 1. 4-FA (4-fluoroamphetamine) - active at 50mg oral. Considered to be recreationally desirable.
  156. 2. 3-FA (3-fluoroamphetamine) - active at 20mg. more selective for dopamine and noradrenaline release instead of serotonin.[51] Considered to be recreationally desirable.
  157. 3. 2-FA (2-fluoroamphetamine) - active at 20mg intranasal, 50mg oral. Considered to be recreationally desirable.
  158. 4. 4-FMA (4-fluoromethamphetamine) - active at 20mg. Considered to be recreationally desirable.
  159. 5. 2-FMA (2-fluoromethamphetamine) - active at 100mg oral, 45 intravenous. Considered to be recreationally desirable.
  160. 6. Fenproporex (3-(1-phenylpropan-2-ylamino)propanenitrile) - found in tainted diet pills in 2009.[53]
  161. 7. 4-CA (4-chloroamphetamine) - Although this substance has no recreational potential and is in fact a potent serotonergic neurotoxin, some “legal party pill” producers called “AM-HI-CO” have put it in a series of products[16], with names like “E-Blast” and “Diablo XXX.” 4-CA is a potent neurotoxin, with even one dose potentially causing brain damage.[13] still present in Ecstasy pills (rolls) in California as of March 2014.[69]
  162. 8. PMA (paramethoxyamphetamine) - Recreationally worthless. Responsible for several deaths.[18] Illegal. Test kit results at {9} and {11}.
  163. 9. PMMA (paramethoxymethamphetamine) - See PMA. [22][23] Test kit results at {8}, {9}, and {11}.
  164. 10. 5-Me-MDA (5-methyl-methylenedioxyamphetamine) - active at 40mg. Not considered recreationally desirable.
  165. 11. 2-MA (2-methyl-amphetamine, Ortetamine) - 1/10th the potency of dexamphetamine.[89]
  166. 12. 4-MTA (4-methylthioamphetamine)
  167.  
  168. E. Aminoindanes
  169. 1. MDAI (methylenedioxyaminoindane) - active at 20mg. Considered to be recreationally desirable. activity at NAT, SERT, and DAT can be found at footnote [71]. Test kit results at {5}.
  170. 2. 2-AI (2-aminoindane) - active at 15mg intranasal, 20mg oral. Test kit results at {5}.
  171. 3. 5-IAI (5-iodo-2-aminoindane) - active at 100mg oral. Not considered to be recreationally desirable. activity at NAT, SERT, and DAT can be found at footnote [71]. Test kit results at {5}.
  172. 4. NM-2AI (N-methyl-2-aminoindane) - active at 50mg oral.
  173.  
  174. F. Tropanes/*caines
  175. 1. 3b-FBT (3b-(4-Fluorobenzoyloxy)tropane, fluorotropacocaine) - active at 100mg.
  176. 2. 4’-fluorococaine (4'-FC) - active at 10mg.
  177. 3. Dimethocaine - active at 50mg.
  178.  
  179. G. piperazines
  180. 1. TFMPP (trifluoromethylphenylpiperazine) - active at 30mg.
  181. 2. BZP (benzylpiperazine) - active at 50mg oral. half-life of 5.5 hours. can cause seizures and multi-organ toxicity, although no fatalities have been reported from BZP used alone.[31]
  182. 3. MDBZP (methylenedioxybenzylpiperazine) - can’t find any dosing info about MDBZP itself, but a drug called Fipexide (Attentil, Vigilor, 1-(1,3-benzodioxol-5-ylmethyl)-4-[(4-chlorophenoxy)acetyl]piperazine) metabolizes into MDBZP in the human body. Fipexide was used in France and Italy to treat dementia,[58] but is no longer used due to the occurrence of adverse reactions such as fever and hepatitis.[59]
  183. 4. 2C-B-BZP (4-bromo-2,5-dimethoxy-benzylpiperazine)
  184. 5. pFPP (para-fluorophenylpiperazine) - active at 20mg.
  185.  
  186. H. Miscellaneous
  187. 1. MPA (Methiopropamine, Methamthetamine) - Active at 5mg. Methiopropamine is a somewhat misleading name.[92] Imagine Methamphetamine where the phenyl ring is replaced with a thiophene ring and you have Methiopropamine, the thiophene analogue of Methamphetamine. User reports on Erowid claim it's a less-potent, shorter-lasting version of Methamphetamine.[4] activity at NAT, SERT, and DAT can be found at footnote [71].
  188. 2. Nitracaine (3-(diethylamino)-2,2-dimethylpropyl 4-nitrobenzoate)
  189. 3. 4,4’-DMAR (4,4’-dimethylaminorex, Serotoni) - Active at 30mg. This one is based on 4-methylaminorex, which was in turn based on aminorex, which is a stimulant with effects similar to Dexamphetamine. Aminorex was used medically as an appetite suppressor but was withdrawn because it caused pulmonary hypertension, resulting in a number of deaths. 4-methylaminorex has more effects that include a euphoria and sensory enhancement similar to MDMA, but more lucid. A study performed on rats and another on mice found that 4-MAR is “significantly less neurotoxic than methamphetamine or MDMA”[2], although 4-MAR seems to have inherited aminorex’s problems with causing pulmonary hypertension.[3] Based on the information about those older analogues, 4,4-DMAR may inherit 4-MAR’s recreational effects, but it seems likely it'll do the same with the negative health effects. Already responsible for two deaths.[29]
  190. 4. Camfetamine (N-methyl-3-phenyl-norbornan-2-amine) - analog of fencamfetamine.
  191. 5. 5-IT (5-API, 5(2-aminopropyl)indole) - Active at 20mg, 5-IT has been responsible for the deaths of 14 people in Sweden.[8] Not considered to be recreationally desirable. considered a positional isomer of aMT in the USA and is thus illegal there.
  192. 6. Diclofensine (4-(3,4-Dichlorophenyl)-7-methoxy-2- methyl-1,2,3,4-tetrahydroisoquinoline)
  193. 7. RH-34 (3-[2-(2-methoxybenzylamino)ethyl]-1H-quinazoline-2,4-dione) - ketaserin with the 4-(p-fluorobenzoyl) group replaced by a N-(2-methoxybenzyl) group. a moderate-efficacy 5-HT2A agonist.
  194.  
  195. —————
  196.  
  197. II: PSYCHEDELIC HALLUCINOGENS (SEROTONIN AGONISTS)
  198.  
  199. A. Phenethylamines
  200. 1. 2C-x series - A series of phenethylamine hallucinogens with various properties depending on the group at the 4-position. Mostly discovered by Shulgin’s work into mescaline analogues. 2C = two chains, methoxy groups at positions 2 and 5.
  201. a. 2C-B (4-bromo-2,5-dimethoxyphenethylamine, Nexus) - Active at 5mg. The first 2C to be explicitly scheduled. Considered to be recreationally desirable. Test kit results at {4} and {9}.
  202. I. βk-2C-B - An unusual new drug here. Since 2C-B’s scheduling, an analogue has been created by adding a ketone group to the beta position, much in the same way substituted Cathinones are made.
  203. II. 2C-B-FLY (FLY, 8-bromo-2,3,6,7-benzo-dihydro-difuran-ethylamine) - Bolt two benzofuran rings to the sides of 2C-B and you have FLY. Active at 10mg.
  204. III. Bromo-DragonFLY (3C-bromo-dragonfly, 1-(4-Bromofuro[2,3-f][1]benzofuran-8-yl)propan-2-amine) - Active at 200 micrograms. A potent vasoconstrictor.[24] A Swedish man needed to have the front part of his feet and several fingers on one hand removed after overdosing on it.[25] Responsible for several deaths.[26] One mislabeled batch was sold as 2C-B-FLY, causing several overdoses and at least one death.[27]
  205. b. 2C-C (4-chloro-2,5-dimethoxyphenethylamine) - Active at 15mg. A sedating hallucinogen. Considered to be recreationally desirable. Illegal. Test kit results at {4}.
  206. c. 2C-D (4-methyl-2,5-dimethoxyphenethylamine) - Active at 5 mg. Illegal. Test kit results at {4}.
  207. d. 2C-E (4-ethyl-2,5-dimethoxyphenethylamine) - Active at 5mg. It has killed at least one person in Minnesota.[9] Considered to be recreationally desirable. Illegal. Test kit results at {4} and {9}.
  208. e. 2C-I (4-iodo-2,5-dimethoxyphenethylamine) - Active at 5mg. a stimulating hallucinogen. Considered to be recreationally desirable. Illegal. Test kit results at {4} and {9}.
  209. f. 2C-iP (4-isopropyl-2,5-dimethoxyphenethylamine) - active at 10mg.
  210. g. 2C-P (4-propyl-2,5-dimethoxyphenethylamine) - Active at 2mg. Lasts 8-16 hours. Considered to be recreationally desirable. Illegal. Test kit results at {4}.
  211. h. 2C-T (2C-T-1, 4-thio-2,5-dimethoxyphenethylamine) - Active at 50mg. A sulfur atom at the 4-position opens up a whole subcategory of derivatives, ones not listed usually haven’t even been synthesized/bioassayed yet. Some of them are MAOIs.
  212. I. 2C-T-2 (2,5-Dimethoxy-4-ethylthiophenethylamine)- Active at 5mg. Illegal. Test kit results at {4} and {9}.
  213. II. 2C-T-7 (2,5-Dimethoxy-4-n-propylthiophenethylamine) - Active at 5mg. Illegal. Test kit results at {9}.
  214. III. 2C-T-13 (2,5-dimethoxy-4-(β-methoxyethylthio)phenethylamine) - Active at 25mg.
  215. IV. 2C-T-17 (NIMITZ, 2,5-dimethoxy-4-sec-butylthiophenethylamine) - Active at 60mg.
  216. V. 2C-T-21 (2,5-dimethoxy-4-(2-fluoroethylthio)phenethylamine) - active at 8mg.
  217. i. 2C-N (4-nitro-2,5-dimethoxyphenethylamine) - active at 100mg. illegal.
  218.  
  219. 2. 3C-x series
  220. a. 3C-E (1-(4-ethoxy-3,5-dimethoxyphenyl)propan-2-amine) - Active at 30mg.
  221. b. 3C-P (1-(3,5-dimethoxy-4-propoxyphenyl)propan-2-amine)
  222.  
  223. 3. N-benzylated phenethylamines - Often referred to as “N-Bombs,” a series of chemicals using the 2C-x series as a springboard, adding an N-benzyl group. With recreational use starting in 2010, these drugs are of particular concern, as they are extremely powerful full agonists for the human 5-HT2A receptor. They are extremely cheap per dose and are active in doses of as little as 300 micrograms. Due to the difficulty that most recreational drug users have managing drugs of such high potency, there have been several overdoses, where the lethality of these drugs has reared its head. There are multiple deaths that can be directly attributed to overdosing on an NBOMe series compound.[5] They are NOT as safe as LSD, the classic ultra-powerful hallucinogen, although they are often sold on blotter, much like LSD.
  224. Note: Until I find further information, I would assume that all NBx chemicals below are active at 300 micrograms. The binding affinities of some of these chemicals are available at footnote [20].
  225. a. 25B-NBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine)
  226. b. 25C-NBOMe (2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) - Responsible for at least one death.[6] Considered to be recreationally desirable.
  227. c. 25D-NBOMe (2-(4-methyl-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine)
  228. d. 25I-NBOMe (2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) - Full agonist, binding affinity (Ki) of 0.044nM to 5-HT2A, 2nM to 5-HT2C. Responsible for at least eight deaths.[7] Considered to be recreationally desirable.
  229. e. 25N-NBOMe (2-(4-nitro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine)
  230. f. 25iP-NBOMe (2-[2,5-Dimethoxy-4-(propan-2-yl)phenyl]-N-(2-methoxybenzyl)ethanamine)
  231. g. 25I-NBOH (2-((2-(4-iodo-2,5-dimethoxyphenyl)ethylamino)methyl)phenol) binding affinity (Ki) of 0.061nM at 5-HT2A [19]
  232. h. 25C-NBOH (2-((2-(4-chloro-2,5-dimethoxyphenyl)ethylamino)methyl)phenol)
  233. i. 25I-NBF (2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-fluorophenyl)methyl]ethanamine)
  234. j. 25E-NBOMe (2-(4-Ethyl-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine)
  235. k. 25B-NBF (2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-fluorobenzyl)ethanamine)
  236. l. 25C-NBF (2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-fluorobenzyl)ethanamine)
  237. m. C30-NBOMe (2-(4-chloro-2,5-dimethoxyphenyl)-N-(3,4,5-trimethoxybenzyl)ethanamine)
  238.  
  239. 4. Mescaline analogues
  240. a. Escaline - active at 40mg.
  241. b. Proscaline - active at 30mg.
  242. c. Allylescaline - Active at 20mg. Considered to be recreationally desirable.
  243. d. Methallylescaline (2-{3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl}ethan-1-amine) - active at 40mg.
  244. e. Isoproscaline - active at 40mg.
  245.  
  246. B. Tryptamines
  247. 1. N-alkylated
  248. a. DiPT (diisopropyltryptamine) - active at 15mg.
  249. b. DET (diethyltryptamine) - active at 20mg.
  250. c. DPT (dipropyltryptamine) - active at 75mg oral. Considered to be recreationally desirable. Test kit results at {1}.
  251.  
  252. 2. 4-position substitutions
  253. a. 4-AcO-DMT (psilacetin, 4-acetoxy-dimethyltryptamine) - Active at 10mg. It is a prodrug for 4-HO-DMT (psilocin). Considered to be recreationally desirable. Test kit results at {1}.
  254. b. 4-HO-MET (metocin, 4-hydroxy-methylethyltryptamine) - Active at 5mg. Considered to be recreationally desirable.
  255. c. 4-AcO-MET (metacetin, 4-acetoxy-methylethyltryptamine) - Active at 10mg.
  256. d. 4-AcO-MiPT (mipracetin, 4-acetoxy-methylisopropyltryptamine) - Active at 15mg.
  257. e. 4-HO-DET (ethocin, 4-hydroxy-diethyltryptamine) - Active at 10mg.
  258. f. 4-AcO-DET (ethacetin, 4-acetoxy-diethylltryptamine) - Active at 5mg.
  259. g. 4-AcO-DiPT (ipracetin, 4-acetoxy-diisopropyltryptamine) - Active at 5mg.
  260. h. 4-AcO-DALT (4-acetoxy-diallyltryptamine) - Active at 20mg. Test kit results at {1}.
  261. i. 4-HO-MIPT (miprocin, 4-hydroxy-methisopropyltryptamine) - Active at 5mg.
  262. j. 4-HO-DiPT (iprocin, 4-hydroxy-diisopropyltryptamine) - Active at 5mg.
  263. k. 4-HO-DPT (deprocin, 4-hydroxy-dipropyltryptamine) - Active at 20mg.
  264. l. 4-HO-MPT (meprocin, 4-hydroxy-methpropyltryptamine) - Active at 15mg.
  265. m. 4-HO-MPMI (lucigenol, 4-Hydroxy-N-methyl-(α,N-trimethylene)tryptamine) - Active at 0.5mg.
  266.  
  267. 3. 5-position substitutions
  268. a. 5-MeO-DMT (5-methoxy-dimethyltryptamine) - Active at 2mg vaporized, 3mg intranasal. Test kit results at {1}.
  269. b. 5-MeO-DALT (5-methoxy-diallyltryptamine) - Active at 5mg oral. Test kit results at {1}.
  270. c. 5-MeO-MIPT (moxy, 5-methoxy-methisopropyltryptamine) - Active at 2mg. Considered to be recreationally desirable. Test kit results at {1}.
  271. d. 5-MeO-TMT (Indapex, 5-methoxy-2-methyl-dimethyltryptamine) - Active at 10mg intranasal, 70mg oral.
  272. e. 5-MeO-EiPT (5-methoxy-ethylisopropyltryptamine) - Active at 5mg.
  273. f. 5-MeO-DIPT (foxy, 5-methoxy-diisopropyltryptamine) - Active at 5mg. Considered to be recreationally desirable.
  274. g. 5-MeO-DPT (5-methoxy-dipropyltryptamine)
  275. h. 5-MeO-MPMI (5-Methoxy-N-methyl-(α,N-trimethylene)tryptamine)
  276. i. 5-MeO-NIPT - active at 10mg.
  277. j. 5-MeO-MALT (5-methoxy-methylallyltryptamine) - active at 10mg.
  278.  
  279. 4. LSD derivatives
  280. a. LSZ (Lysergic acid 2,4-dimethylazetidide) - active at 75 micrograms. Considered to be recreationally desirable.
  281. b. AL-LAD - active at 80 micrograms. Considered to be recreationally desirable.
  282. c. ALD-52 - active at 80 micrograms. Considered to be recreationally desirable.
  283. d. ETH-LAD - active at 40 micrograms.
  284. e. PRO-LAD - active at 100 micrograms.
  285.  
  286. 5. α-position substitutions
  287. a. αMT (alpha-methyltryptamine) - Active at 5mg. Used as an antidepressant in Russia, also an MAOI. Considered to be recreationally desirable.
  288. I. 5-MeO-αMT (5-methoxy-alpha-methyltryptamine) - active at 0.5mg. Has often been confused for αMT, which has lead to a number of accidental overdoses[94] and at least one death.[93] Considered to be recreationally desirable.
  289. b. αET (alpha-ethyltryptamine) - active at 75mg.
  290.  
  291. 6. 2-position modifications
  292. a. 2-Me-DMT (2-methyl-dimethyltryptamine, trimethyltryptamine, TMT) - active at 60mg.
  293.  
  294. C. Substituted Amphetamines
  295. 1. DOB (2,5-dimethoxy-4-bromoamphetamine) - Active at 1mg. Illegal. Considered to be recreationally desirable. Test kit results at {9}.
  296. 2. DOC (2,5-dimethoxy-4-chloroamphetamine) - Active at 0.5mg. Considered to be recreationally desirable. Unscheduled, but considered an analogue of DOB.
  297. 3. DOI (2,5-dimethoxy-4-iodoamphetamine) - active at 1.5mg. Test kit results at {9}.
  298. 4. DOM (STP, 2,5-Dimethoxy-4-methylamphetamine) - Active at 1mg. Illegal. Considered to be recreationally desirable.
  299. 5. Trimethoxyamphetamines (TMAs)
  300. a. TMA (3,4,5-trimethoxyamphetamine) - active at 100mg
  301. b. TMA-2 (2,4,5-trimethoxyamphetamine) - active at 10mg
  302. c. TMA-6 (2,4,6-trimethoxyamphetamine) - active at 15mg
  303.  
  304. —————
  305.  
  306. III. SEDATIVES
  307.  
  308. A. Benzodiazepines - Analogues of commonly-used GABA allosteric modulators like Xanax (Alprazolam) and Valium (Diazepam).
  309. 1. Etizolam - Active at 0.5mg. technically a thienodiazepine, Etizolam has effects closer to that of benzodiazepines than that of other thienodiazepines (such as the antipsychotic Zyprexa). It is commonly sold over the internet as powder or pressed into pellets of various colors and used medicinally in India and Japan. There is evidence that it can increase prolactin levels.[10] It is a risk factor for blepharospasms.[68] Considered to be recreationally desirable.
  310. 2. Flubromazepam - Active at 4mg.
  311. 3. Diclazepam (chlorodiazepam) - Active at 0.5mg
  312. 4. Pyrazolam - Active at 0.5mg
  313. 5. Phenazepam - Active at 0.5mg. Discovered in Russia and still used as a sedative there to this day. Has a half-life of 36 hours. Generally not preferred for recreation.
  314. 6. CL-218,872 (3-methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[3,4-f]pyridazine) - found on adulterated plant blends in June 2012. has effects similar to benzodiazepines, but is more structurally similar to cannabinoids.[34]
  315. 7. Premazepam - active at 7.5mg.[88]
  316. 8. Meclonazepam - has sedative/anxiolytic effects comparable to that of other benzos,[95] in addition to having anti-parasitic effects against the parasitic worm Schistosoma mansoni.[96]
  317.  
  318. B. Qualones - Derivatives of Methaqualone (Quaaludes).
  319. 1. Methylmethaqualone - Active at 20mg. causes seizures at high doses.
  320. 2. Etaqualone - Active at 300mg.
  321. 3. Mebroqualone - active at 15mg sublingual.
  322. 4. Mecloqualone - half-life of 2 days.[43]
  323.  
  324. C. Barbiturates
  325. 1. Benzylbutylbarbiturate (5-benzyl-5-(n)-butylbarbituric acid)
  326.  
  327. —————
  328.  
  329. IV. OPIOID ANALGESICS
  330.  
  331. A. Kratom - A tree indigenous to southeast Asia with leaves containing a variety of substances, including an opioid. Has a long history of use in Thailand, where it is illegal. Potentially hepatotoxic.[11] plain leaf is active at ~3g oral.
  332. 1. Extracts / enhanced products - There are a wide variety of enhanced products offered by various internet vendors. One vendor called Speciosa Specialists has created a tincture of Kratom that is very powerful (1ml FST ~= 30mg oxycodone) and has a very real risk of abuse. It is, as of March 2014, unclear what exactly is in the tincture. I suspect it is an extract of 7-hydroxy-mitragynine (7-HO-MIT), the most powerful opioid that appears naturally in the Kratom leaf itself and is 17x the potency of morphine. 7-OHM is present in extremely small quantities in leaf, so the tincture is much more susceptible to abuse than the leaf. There also may be mitragynine-pseudoindoxyl analogs available.[61]
  333.  
  334. B. AH-7921 (3,4-dichloro-N-[(1-dimethylamino)-cyclohexylmethyl]benzamide) - Active at 20mg.
  335. C. MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) - Active at 20mg.
  336. D. Bromadol - 504x the potency of morphine for the trans-isomer.[57] found in fake oxycodone tablets in Canada in 2013.[62]
  337. E. Fentanyl derivatives
  338. 1. Acetylfentanyl - 40x the potency of heroin, this analogue has popped up recently and killed at least 10 people, perhaps as a cheap substitute for heroin.[12] there is more info available from the CDC.[63]
  339. 2. Butyrfentanyl
  340. 3. 3-methylfentanyl (Kolokol-1) - between 400-6000x the potency of morphine.[40] has been used as a heroin cut in “China White.”.[37] also used as an aerosol gas form in “Kolokol-1”[39] in the 2002 Moscow Theater hostage crisis to sedate the militants, all 40 militants and over 100 hostages were killed directly from the gas.[38]
  341. 4. Ohmefentanyl (N-[(3R,4S)-1-[(2S)-2-hydroxy-2-phenyl-ethyl] -3-methyl-4-piperidyl]-N-phenyl-propanamide) - 6300x the potency of morphine.[41]
  342. 5. alpha-methylfentanyl - another chemical used as a heroin cut in “China White.”[42][37]
  343. 6. desmethylfentanyl - found in fake oxycodone tablets in Canada in 2013.[62] As of February 2014 continues to do so.[64]
  344.  
  345. F. O-Desmethyltramadol - active at 20mg intranasal. An analogue of Tramadol, it is actually an active metabolite of Tramadol in the body. It has much greater affinity for μ-opioid receptors than Tramadol itself. Was present in an adulterated Kratom leaf blend called Krypton and caused several deaths consumed in this form.[56] Considered to be recreationally desirable.
  346. G. W-15 (1-Phenylethylpiperidylidene-2-(4-chlorophenyl)sulfonamide) - approximately 5.4x the potency of morphine in a phenylquinone writing test when administered subcutaneously.[33]
  347. H. W-18 (1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide) - 10000x the potency of morphine in a phenylquinone writing test,[33] it is similar strength to carfentanyl but not structurally related to currently-scheduled opioids.
  348. I. MPPP (1-Methyl-4-phenyl-4-propionoxypiperidine) - one that will hopefully never return. 70% the potency of morphine, MPPP has a common contaminant from sloppy synthesis called MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine). MPTP is a potent dopaminergic neurotoxin and was responsible for several deaths and onsets of Parkinson’s disease.[75]
  349.  
  350. —————
  351.  
  352. V. SYNTHETIC CANNABINOIDS - These substances are active in single-digit milligram to sub-milligram doses, so vendors often distribute them by measuring doses, dissolving them in Acetone and spraying them on to various inactive plant matter such as Damiana to be sold as “Incense” or “Potpourri.”
  353.  
  354. A. JWH series - named after John W. Huffman, who discovered them.
  355. 1. Napthoylindoles [66]
  356. a. JWH-018 (AM-678, (1-pentyl-3-(1-naphthoyl)indole) - binding affinities: 9.00 ± 5.00 nM at CB1 2.94 ± 2.65 nM at CB2 [46]. detectable with urine testing.[50] illegal in the USA. Test kit results at {3}.
  357. b. JWH-019 - detectable with urine testing.[50]
  358. c. JWH-073 - detectable with urine testing.[50] Test kit results at {3}.
  359. d. JWH-081 - Ki of 1.2 nM at CB1 [48]. detectable with urine testing.[50] Test kit results at {3}.
  360. I. JWH-081-N-(cyclohexylmethyl) - DEA microgram journal confirms this one’s presence in “incense” products sold in the USA as of 2013.[32]
  361. e. JWH-122 - Ki values: 0.69nM at CB1, 1.2nM at CB2.[81] detectable with urine testing.[50]
  362. f. JWH-182
  363. g. JWH-007
  364. h. JWH-098 - illegal in Russia, Sweden, and the UK.
  365.  
  366. 2. Phenylacetylindoles [67]
  367. a. JWH-203
  368. b. JWH-249
  369. c. JWH-250 - Test kit results at {3}.
  370. d. JWH-251
  371.  
  372. 3. 4-alkyl substitutions
  373. a. JWH-210 - (CB1 Ki = 0.46 nM, CB2 Ki = 0.69 nM)[65]
  374.  
  375. 4. aminoalkylindoles
  376. a. JWH-200 (WIN-55,225, (1-(2-morpholin-4-ylethyl)indol-3-yl)-naphthalen-1-ylmethanone) - Test kit results at {3}.
  377. b. Pravadoline (WIN-48,098, (4-methoxyphenyl)-[2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]methanone)
  378.  
  379. B. AM series
  380. 1. AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) - Test kit results at {3}.
  381. 2. AM-2201 - linked to acute kidney injury.[36] detectable with urine testing.[50]
  382. 3. AM-2233 (1-[(N-methylpiperidin-2-yl)methyl]-3-(2-iodobenzoyl)indole) - Ki values for the active (R) enantiomer: 1.8nM at CB1, 2.2nM at CB2.[83]
  383. 4. AM-1248
  384. 5. MAM-2201 (5F-JWH-122, [1-(5-fluoropentyl)-1H-indol-3-yl](4-methyl-1- naphthalenyl)-methanone) - 4-methylnapthyl analog of AM-2201. Test kit results at {7}.
  385. 6. AM-2232 ((1-(4-cyanobutyl)-3-(naphthalen-1-oyl)indole))
  386. 7. AM-679 (1-pentyl-3-(2-iodobenzoyl)indole)
  387. 8. AM-630 (6-iodopravadoline) - weak partial agonist for CB1, inverse agonist for CB2.[82]
  388. 9. AM-1221 (1-[(N-methylpiperidin-2-yl)methyl]-2-methyl-3-(naphthalen-1-oyl)-6-nitroindole)
  389. 10. AM-1241 (1-(methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole)
  390. 11. AM-1220 ((R)-(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone)
  391.  
  392. C. Others
  393. 1. RCS-4 (SR-19, 1-pentyl-3-(4-methoxybenzoyl)indole)
  394. 2. APINACA (AKB-48, 1-pentyl-N-tricyclo[3.3.1.13, 7]dec-1-yl-1H-indazole-3-carboxamide)
  395. 3. UR-144 - Ki values: 150nM at CB1, 1.8nM at CB2.[49] detectable with urine testing.[50] Test kit results at {6}.
  396. 4. 5F-UR-144 (XLR-11, (1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone) - associated with acute kidney injury.[36] detectable with urine testing.[50]
  397. 5. QUPIC (PB-22, 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester) - detectable with urine testing.[50] found in synthetic cannabis blends in Japan in 2013.[90]
  398. 6. 5F-QUPIC (5F-PB-22, 8-quinolinyl ester-1-(5-fluoropentyl)-1H-indole-3-carboxylic acid)
  399. 7. 5F-APINACA (5F-AKB-48)
  400. 8. 5F-AB-PINACA (N-[(1R)-1-carbamoyl-2-methyl-propyl]-1-(4-fluorobutyl)indazole-3-carboxamide)
  401. 9. AB-PINACA (N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-1-pentyl-1H-indazole-3-carboxamide)
  402. 10. AB-CHMINACA ((R)-N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide)
  403. 11. APICA (2-NE1, SDB-001, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide) - full agonist at CB1 (EC50 = 34nM) and CB2 (EC50 = 29nM).[80]
  404. 12. QUCHIC (BB-22, 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester) - found in synthetic cannabis blends in Japan in 2013.[90]
  405. 13. AB-FUBINACA (N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide)
  406. 14. CB-13 (SAB-378, naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone)
  407. 15. MDA-19 ((2Z)-2-(1-hexyl-1,2-dihydro-2-oxo-3H-indol-3- ylidene)hydrazide, benzoic acid)
  408. 16. HU-210 (1,1-dimethylheptyl-11-hydroxytetrahydrocannabinol) - 100-800x the potency of THC.[47]
  409. 17. EG-018 (naphthalen-1-yl(9-pentyl-9H-carbazol-3-yl)methanone)
  410. 18. 5F-AMB ((R)-methyl-2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate) - analogue of AB-PINACA
  411. 19. FUB-PB22 (naphthalen-1-yl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate) - analog of PB-22 with the pentyl side chain replaced by a 4-fluorobenzyl group and the 8-quinolinol replaced by a naphthalene group.
  412. 20. MN-24 (NNE1, AM-6527, N-1-naphthalenyl-1-pentyl-1H-indole-3- carboxamide)
  413. 21. FAB-144 (1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone) - analogue of 5F-UR-144.
  414. 22. 5F-MN-18 (1-(5-fluoropentyl)-N-(naphthalen-1-yl)-1H-indazole-3-carboxamide)
  415. 23. AB-001 (1-pentyl-3-(1-adamantoyl)indole)
  416. 24. RCS-8 (SR-18, BTM-8, 1-(2-cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole)
  417. 25. JTE-907 (N-(benzo[1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxamide) - this is a selective CB2 inverse agonist.[79]
  418. 26. STS-135 (5F-APICA, N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide) - terminally-fluorinated analog of APICA.
  419. 27. 5F-MN-24 (5F-NNE1, 1-(5-fluoropentyl)-N-(naphthalen-1-yl)-1H-indole-3-carboxamide)
  420. 28. MN-25 (UR-12, 7-methoxy-1-(2-morpholinoethyl)-N-((1S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-1H-indole-3-carboxamide (N-[(S)-fenchyl]-1-[2-(morpholin-4-yl)ethyl]-7-methoxyindole-3-carboxamide)
  421. 29. Org-28611 (SCH-900,111 , [1-(cyclohexylmethyl)-7-methoxyindol-3-yl]-[(3S)-3,4-dimethylpiperazin-1-yl]methanone)
  422. 30. CP-47,497 (cannabicyclohexanol, 2-[(1R,3S)-3-hydroxycyclohexyl]- 5-(2-methyloctan-2-yl)phenol) - Test kit results at {3}.
  423. 31. JTE 7-31 (2-[2-(4-hydroxyphenyl)ethyl]-5-methoxy-4-(pentylamino)-2,3-dihydro-1H-isoindol-1-one) - discovered by Japan Tobacco, Ki values: 11nM at CB1, 0.088nM at CB2.[84]
  424. 32. A-834,735 (1-(tetrahydropyran-4-ylmethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone) - Abbott Laboratories. Ki values: 12nM at CB1, 0.21nM at CB2.[85]
  425. 33. A-796,260 (1-(2-morpholin-4-ylethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone) - Abbott Laboratories. Ki values: 945nM at CB1, 4.6nM at CB2.[85]
  426. 34. A-836,339 (N-[3-(2-methoxyethyl)-4,5-dimethyl-1,3-thiazol-2-ylidene]-2,2,3,3-tetramethylcyclopropane-1-carboxamide) - Abbott Laboratories. Ki values: 270nM at CB1, 0.64nM at CB2.[86]
  427. 35. ADB-FUBINACA (N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide) - found in synthetic cannabis blends in Japan in 2013.[90] Ki value of 0.36nM at CB1.[91]
  428. 36. ADBICA (N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indole-3-carboxamide) - found in synthetic cannabis blends in Japan in 2013.[90]
  429. 37. CP-55,940 - Test kit results at {3}.
  430.  
  431. D. THJ series
  432. 1. THJ-018 (1-naphthalenyl(1-pentyl-1H-indazol-3-yl)-methanone) - Indazole analogue of JWH-018
  433. 2. THJ-2201 (1-[(5-fluoropentyl)-1H-indazol-3-yl](naphthalen-1-yl)methanone) - Indazole analogue of AM-2201
  434. 3. THJ (1-pentyl-N-(quinolin-8-yl)-1H-indazole-3-carboxamide)
  435.  
  436. E. Endocannabinoid reuptake inhibitors - these drugs, instead of directly agonizing cannabinoid receptors, increase concentrations of cannabinoids already present in the body, such as anandamide.
  437. 1. URB-597 ([3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate)
  438. 2. LY-2,183,240 (N,N-dimethyl-5-[(4-biphenyl)methyl]tetrazole-1-carboxamide)
  439. 3. URB-754 (6-methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one)
  440.  
  441. —————
  442.  
  443. VI. DISSOCIATIVE HALLUCINOGENS (NMDA ANTAGONISTS)
  444.  
  445. A. Methoxetamine (MXE, 3-MeO-2-Oxo-PCE) - Active at 5mg. Test kit results at {9}.
  446. B. Diphenidine ((±)-1-(1,2-Diphenylethyl)piperidine) - active at 60mg intranasal
  447. 1. Methoxphenidine (MXP, 2-MeO-Diphenidine) - active at 60mg
  448.  
  449. C. Ketamine analogues
  450. 1. 2-MeO-Ketamine (2-(2-Methoxyphenyl)-2-(methylamino)cyclohexanone) - active at 50mg.
  451. 2. N-Ethyl-Norketamine (NEK, ethketamine, 2-(2-chlorophenyl)-N-(ethylamino)cyclohexanone) - active at 50mg.
  452.  
  453. D. PCP analogues
  454. 1. 3-MeO-PCP (3-methoxy-phencyclidine, 1-[1-(3-methoxyphenyl)cyclohexyl]-piperidine) - active at 10mg sublingual.
  455. 2. 4-MeO-PCP (4-methoxy-phencyclidine, 1-[1-(4-methoxyphenyl)cyclohexyl]-piperidine) - active at 25mg. impure, sloppy synthesis can produce very dangerous byproducts.[76] Test kit results at {1}.
  456.  
  457. E. Tiletamine - responsible for several deaths in combination with zolazepam. often abused as Telazol, a veterinary anesthetic which is 1:1 parts tiletamine/zolazepam.[60]
  458. F. Dizocilpine (MK-801) - One fatality involving MK-801, Benzodiazepines, and Alcohol[15]
  459.  
  460. —————
  461.  
  462. VII. TEST KIT RESULTS - varying-quality test kit results on various drugs from various reagents.
  463. {1} various tryptamines, 4-meo-pcp - http://www.google.com/imgres?sa=X&rlz=1C5CHFA_enUS565US565&espvd=210&es_sm=91&biw=1280&bih=590&tbm=isch&tbnid=MZ6-0l41c7ejzM%3A&imgrefurl=http%3A%2F%2Fwww.tripproject.ca%2Ftrip%2F%3Fq%3Dnode%2F2005&docid=p59KdL8EelwpsM&imgurl=http%3A%2F%2Fwww.benzo-fury.me.uk%2Fimages%2Ftest%2FTryptamines.jpg&w=854&h=1417&ei=2r4fU-bIM-TF0QHf8oD4CA&zoom=1&ved=0CFoQhBwwAg&iact=rc&dur=2094&page=1&start=0&ndsp=18
  464. {2} methylone, mephedrone, butylone - http://www.google.com/imgres?sa=X&rlz=1C5CHFA_enUS565US565&espvd=210&es_sm=91&biw=1280&bih=590&tbm=isch&tbnid=SLxS152zBAeC3M%3A&imgrefurl=http%3A%2F%2Fwww.bluelight.org%2Fvb%2Fthreads%2F512598-Marquis-Mecke-Mandellin-results-for-stim-empathogen-2C-X-RC-s-amp-more%2Fpage2&docid=lahNZkuWKpu4wM&imgurl=http%3A%2F%2Fimg13.imageshack.us%2Fimg13%2F6495%2Fuser60367pic68171260235.jpg&w=600&h=450&ei=2r4fU-bIM-TF0QHf8oD4CA&zoom=1&ved=0CGYQhBwwBg&iact=rc&dur=622&page=1&start=0&ndsp=18
  465. {3} various cannabinoids - http://www.google.com/imgres?start=115&sa=X&rlz=1C5CHFA_enUS565US565&espvd=210&es_sm=91&biw=1280&bih=590&tbm=isch&tbnid=KncG8QIIhQiqhM%3A&imgrefurl=http%3A%2F%2Fwww.research-chemical-wholesale.com%2Fpage_4&docid=7Ou1LaaR_14BCM&imgurl=http%3A%2F%2Fwww.research-chemical-wholesale.com%2Fimages%2Ftest%2FSynthetic-Cannabinoids.jpg&w=744&h=734&ei=4MAfU5PrOuuL0QGZ9oCICQ&zoom=1&ved=0CFcQhBwwGjhk&iact=rc&dur=3080&page=8&ndsp=16
  466. {4} various 2C-x chemicals - http://www.google.com/imgres?start=115&sa=X&rlz=1C5CHFA_enUS565US565&espvd=210&es_sm=91&biw=1280&bih=590&tbm=isch&tbnid=2Dr15WOj5wqodM%3A&imgrefurl=http%3A%2F%2Fwww.research-chemical-wholesale.com%2Fpage_4&docid=7Ou1LaaR_14BCM&imgurl=http%3A%2F%2Fwww.research-chemical-wholesale.com%2Fimages%2Ftest%2FPsychedelics-Phenethylamines.jpg&w=549&h=712&ei=4MAfU5PrOuuL0QGZ9oCICQ&zoom=1&ved=0CDwQhBwwEThk&iact=rc&dur=2517&page=8&ndsp=16
  467. {5} various stimulants - http://www.google.com/imgres?start=223&sa=X&rlz=1C5CHFA_enUS565US565&espvd=210&es_sm=91&biw=1280&bih=590&tbm=isch&tbnid=OaD0BExuMiOy6M%3A&imgrefurl=http%3A%2F%2Fwww.bluelight.org%2Fvb%2Fthreads%2F513513-The-6-APB-thread-(Part-2)%2Fpage19&docid=2BXMqhSvF4kWmM&imgurl=http%3A%2F%2Fi28.tinypic.com%2F255rwh4.jpg&w=1200&h=1600&ei=VcMfU8n_AfS60AGonYGQCg&zoom=1&ved=0CFcQhBwwGjjIAQ&iact=rc&dur=2079&page=14&ndsp=19
  468. {6} UR-144 - http://www.google.com/imgres?start=205&sa=X&rlz=1C5CHFA_enUS565US565&espvd=210&es_sm=91&biw=1280&bih=590&tbm=isch&tbnid=fIih5Jucv9H4IM%3A&imgrefurl=http%3A%2F%2Fwww.drugs-forum.com%2Fforum%2Fshowthread.php%3Ft%3D210553&docid=XNrjex3Snq493M&imgurl=http%3A%2F%2Fwww.shahspace.com%2FUR-144.jpg&w=500&h=375&ei=VcMfU8n_AfS60AGonYGQCg&zoom=1&ved=0CBgQhBwwBTjIAQ&iact=rc&dur=876&page=13&ndsp=18
  469. {7} MAM-2201 - http://www.google.com/imgres?start=149&sa=X&rlz=1C5CHFA_enUS565US565&espvd=210&es_sm=91&biw=1280&bih=590&tbm=isch&tbnid=DYK9x1PcfL-eJM%3A&imgrefurl=http%3A%2F%2Fwww.drugs-forum.com%2Fforum%2Fshowthread.php%3Ft%3D210553&docid=XNrjex3Snq493M&imgurl=http%3A%2F%2Fwww.shahspace.com%2FMAM-2201.jpg&w=500&h=375&ei=BMMfU5mKL4bi0QG13YCYDw&zoom=1&ved=0CK4BEIQcMDc4ZA&iact=rc&dur=1841&page=10&ndsp=19
  470. {8} PMMA - http://www.google.com/imgres?start=115&sa=X&rlz=1C5CHFA_enUS565US565&espvd=210&es_sm=91&biw=1280&bih=590&tbm=isch&tbnid=1jKYNPBaopkdxM%3A&imgrefurl=http%3A%2F%2Fwww.bluelight.org%2Fvb%2Fthreads%2F690310-PMMA-Reactions-to-Marquis-Mandelin-Mecke-Simons-amp-Robadope-(GC-MS-Verified)&docid=yezEz1F1Jrp77M&imgurl=http%3A%2F%2Fimageshack.us%2Fa%2Fimg43%2F958%2Fzbcg.jpg&w=1236&h=606&ei=BMMfU5mKL4bi0QG13YCYDw&zoom=1&ved=0CEgQhBwwFThk&iact=rc&dur=1330&page=8&ndsp=16
  471. {9} the reference sheet made by DanceSafe - http://imgur.com/bO8o4z0, http://www.dancesafe.org/wp-content/uploads/2014/02/kit-instructions-back.jpg
  472. {10} BunkPolice.org reference sheet for Marquis reagent - http://bunkpolice.org/basic-test-kit/, http://www.bunkpolice.org/wp-content/uploads/Marquis-Infographic61.jpg
  473. {11} BunkPolice.org reference sheet for Mandelin reagent - http://bunkpolice.org/mandelin-test-kit/, http://www.bunkpolice.org/wp-content/uploads/Mandelin-Infographic3.jpg
  474. {12} BunkPolice.org reference sheet for Ehrlich reagent - http://bunkpolice.org/ehrlichs-test-kit/, http://bunkpolice.org/wp-content/uploads/2012/09/ehrlichs_infographic.jpg
  475.  
  476. —————
  477.  
  478. VIII. REFERENCES
  479. thank you to everyone discovering and spreading information
  480.  
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