["hello","18hs","18aaa","21hr"]

>>> import re
>>> words = ["hello", "18hs", "18aaa", "21hr"]
>>> [w for w in words if not re.match(r'd+h', w)]
['hello', '18aaa']

my_list = ["hello","18hs","18aaa","21hr"] # input data

custom_filters = [lambda x: not x.endswith('hr'),
                  lambda x: not x.endswith('hs'),
                  lambda x: not x.endswith('h')] # define custom filters

final = list(filter(lambda x: all([custom_filter(x) for custom_filter in custom_filters]), my_list)) # apply custom filters one by one

# should result in ["hello", "18aaa"]

>>> import re
>>> words = ["hello", "18hs", "18aaa", "21hr"]
>>> [w for w in words if not re.match(r'd+h', w)]
['hello', '18aaa']

>>> words = ["hello", "18hs", "18aaa", "21hr", '7hg']
>>> [w for w in words if not re.match(r'd+h(s|r)$', w)]
['hello', '18aaa', '7hg']