data =  pd.DataFrame(np.random.randn(5, 3), columns=list('ABC'))
#print (data)

def highlight_cols(x):
    #copy df to new - original data are not changed
    df = x.copy()
    #select all values to default value - red color
    df.loc[:,:] = 'background-color: red'
    #overwrite values grey color
    df[['B','C']] = 'background-color: grey'
    #return color df
    return df

data.style.apply(highlight_cols, axis=None)