usepackage{lscape}
begin{landscape}
    small
    begin{center}
    caption{Central composite design in the original and coded (between brackets) form of the independent variables percentage of modifier (A), temperature  (B) and pressure (C) and experimental results for the response variables, retention factors of lycopene (k$_{1}$), beta-carotene (k$_{2}$), coenzyme Q10 (k$_{3}$) and lutein (k$_{4}$) and separation factors of the pairs lycopene/beta-carotene ($alpha_{12}$), beta-carotene/coenzyme Q10 ($alpha_{23}$) and coenzyme Q10/lutein ($alpha_{34}$), between brackets the standard deviation.}
    label{ANOVA4a}
    begin{tabular}{P{1.0cm}|P{3cm}|P{2.9cm}|P{2.3cm}|P{1.5cm}|P{1.5cm}|P{1.5cm}|P{1.5cm}|P{1.5cm}|P{1.5cm}|P{1.5cm}}
    hline
    textbf{Run} & multicolumn{3}{c}{textbf{Factor}} & multicolumn{7}{c}{textbf{Response}}\
    hline
     & Percentage of modifier (A) & Temperature (B) & Pressure (C) & k$_{1}$ & k$_{2}$ & k$_{3}$ & k$_{4}$ & $alpha_{12}$ & $alpha_{23}$ & $alpha_{34}$\
    hline
     1 & 24 (+1) & 25 (-1) & 2200 (+1) & 1.59 ($pm$0.02) & 2.01 ($pm$0.02) & 2.01 ($pm$0.02) & 3.63 ($pm$0.02) &    1.27 ($<$0.01) & 0.97 ($pm$0.04) & 1.80 ($<$0.01)\
     hline
    end{tabular}
    end{center}
end{landscape}