kwargs = {}
if platform.system() == 'Windows':
    # from msdn [1]
    CREATE_NEW_PROCESS_GROUP = 0x00000200  # note: could get it from subprocess
    DETACHED_PROCESS = 0x00000008          # 0x8 | 0x200 == 0x208
    kwargs.update(creationflags=DETACHED_PROCESS | CREATE_NEW_PROCESS_GROUP)
    kwargs.update(stderr=subprocess.PIPE)
elif sys.version_info < (3, 2):  # assume posix
    kwargs.update(preexec_fn=os.setsid)
else:  # Python 3.2+ and Unix
    kwargs.update(start_new_session=True)

subprocess.Popen([APP], stdin=subprocess.PIPE, stdout=subprocess.PIPE, stderr=subprocess.PIPE,**kwargs)