from random import randint

number = None
guess = None
winner = False
wanna_play = None

while winner != True:
    number = randint(1,10)
    guess = int(input("I have picked a number between 1 and 10. Which one is it? "))
    if guess == number:
        winner = True
        print("You win!")
        wanna_play = input("Play again? (y/n) ")
        if wanna_play == "y":
            winner = False
        else:
            print("Thanks, bye!")
            break

    elif guess > number:
        guess = int(input("Too high! So? "))
    else:
        guess = int(input("Too low! So? "))