def SkewArray_new(Genome):
    base_pairs = {'A': 0, 'T': 0, 'G': 1, 'C': -1}
    skew = [0]
    skew = [base_pairs.get(n[1]) for n in enumerate(Genome)]
    return skew

# I need this:
[0, -1, -1, -1, 0, 1, 2, 1, 1, 1, 0, 1, 2, 1, 0, 0, 0, 0, -1, 0, -1, -2]

# But as I am not accumulation, I get this:
[-1, 0, 0, 1, 1, 1, -1, 0, 0, -1, 1, 1, -1, -1, 0, 0, 0, -1, 1, -1, -1]