Does cholesterol play a role in COVID-19?

A new study published on the preprint server bioRxiv* in May 2020 suggests that the strikingly increased mortality in COVID-19 patients who are either old or also have high blood pressure, diabetes, cardiovascular disease is due to high tissue cholesterol levels. It also indicates the role of a healthy diet, by showing that polyunsaturated fatty acids (PUFA) in blood oppose the effects of cholesterol and thus the risk for severe COVID-19 symptoms.
Variation in Infectivity Between Adults and Children
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19 disease, is known to infect and enter host cells employing the ACE2 receptor molecule present on the outside of the host cell membrane. It was initially thought that low ACE2 levels in children caused the decreased risk for this condition, but recent studies show that this is not necessarily always true. Some children show high ACE2 levels in early childhood.
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