add_action( 'phpmailer_init', 'wpse8170_phpmailer_init' );
function wpse8170_phpmailer_init( PHPMailer $phpmailer ) {
    $phpmailer->Host = 'your.smtp.server.here';
    $phpmailer->Port = 25; // could be different
    $phpmailer->Username = 'your_username@example.com'; // if required
    $phpmailer->Password = 'yourpassword'; // if required
    $phpmailer->SMTPAuth = true; // if required
    // $phpmailer->SMTPSecure = 'ssl'; // enable if required, 'tls' is another possible value

    $phpmailer->IsSMTP();
}

<?php
defined( 'ABSPATH' ) OR exit;
/**
 * Plugin Name: (WCM) PHPMailer SMTP Settings
 * Description: Enables SMTP servers, SSL/TSL authentication and SMTP settings.
 */

add_action( 'phpmailer_init', 'phpmailerSMTP' );
function phpmailerSMTP( $phpmailer )
{
    # $phpmailer->IsSMTP();
    # $phpmailer->SMTPAuth   = true;  // Authentication
    # $phpmailer->Host       = '';
    # $phpmailer->Username   = '';
    # $phpmailer->Password   = '';
    # $phpmailer->SMTPSecure = 'ssl'; // Enable if required - 'tls' is another possible value
    # $phpmailer->Port       = 26;    // SMTP Port - 26 is for GMail
}

<?php
defined( 'ABSPATH' ) OR exit;
/**
 * Plugin Name: (WCM) PHPMailer Exceptions & SMTP
 * Description: WordPress by default returns <code>FALSE</code> instead of an <code>Exception</code>. This plugin fixes that.
 */

add_action( 'phpmailer_init', 'WCMphpmailerException' );
function WCMphpmailerException( $phpmailer )
{
    if ( ! defined( 'WP_DEBUG' ) OR ! WP_DEBUG )
    {
        $phpmailer->SMTPDebug = 0;
        $phpmailer->debug = 0;
        return;
    }
    if ( ! current_user_can( 'manage_options' ) )
        return;

    // Enable SMTP
    # $phpmailer->IsSMTP();
    $phpmailer->SMTPDebug = 2;
    $phpmailer->debug     = 1;

    // Use `var_dump( $data )` to inspect stuff at the latest point and see
    // if something got changed in core. You should consider dumping it during the
    // `wp_mail` filter as well, so you get the original state for comparison.
    $data = apply_filters(
        'wp_mail',
        compact( 'to', 'subject', 'message', 'headers', 'attachments' )
    );

    current_user_can( 'manage_options' )
        AND print htmlspecialchars( var_export( $phpmailer, true ) );

    $error = null;
    try
    {
        $sent = $phpmailer->Send();
        ! $sent AND $error = new WP_Error( 'phpmailerError', $sent->ErrorInfo );
    }
    catch ( phpmailerException $e )
    {
        $error = new WP_Error( 'phpmailerException', $e->errorMessage() );
    }
    catch ( Exception $e )
    {
        $error = new WP_Error( 'defaultException', $e->getMessage() );
    }

    if ( is_wp_error( $error ) )
        return printf(
            "%s: %s",
            $error->get_error_code(),
            $error->get_error_message()
        );
}

/**
 * Set the following constants in wp-config.php
 * These should be added somewhere BEFORE the
 * constant ABSPATH is defined.
 */
define( 'SMTP_USER',   'user@example.com' );    // Username to use for SMTP authentication
define( 'SMTP_PASS',   'smtp password' );       // Password to use for SMTP authentication
define( 'SMTP_HOST',   'smtp.example.com' );    // The hostname of the mail server
define( 'SMTP_FROM',   'website@example.com' ); // SMTP From email address
define( 'SMTP_NAME',   'e.g Website Name' );    // SMTP From name
define( 'SMTP_PORT',   '25' );                  // SMTP port number - likely to be 25, 465 or 587
define( 'SMTP_SECURE', 'tls' );                 // Encryption system to use - ssl or tls
define( 'SMTP_AUTH',    true );                 // Use SMTP authentication (true|false)
define( 'SMTP_DEBUG',   0 );                    // for debugging purposes only set to 1 or 2

/**
 * This function will connect wp_mail to your authenticated
 * SMTP server. Values are constants set in wp-config.php
 */
add_action( 'phpmailer_init', 'send_smtp_email' );
function send_smtp_email( $phpmailer ) {
    $phpmailer->isSMTP();
    $phpmailer->Host       = SMTP_HOST;
    $phpmailer->SMTPAuth   = SMTP_AUTH;
    $phpmailer->Port       = SMTP_PORT;
    $phpmailer->Username   = SMTP_USER;
    $phpmailer->Password   = SMTP_PASS;
    $phpmailer->SMTPSecure = SMTP_SECURE;
    $phpmailer->From       = SMTP_FROM;
    $phpmailer->FromName   = SMTP_NAME;
}