Public Class Form1
    Private Sub submit_Click(sender As System.Object, e As System.EventArgs) Handles submit.Click
        Dim user As String
        Dim pass As String
        user = uname.Text
        pass = passwd.Text

        Dim request As WebRequest = WebRequest.Create("http://domain.com/test.php")
        request.Method = "POST"
        Dim postData As String
        postData = "username=" & user & "&password=" & pass
        Dim byteArray As Byte() = Encoding.UTF8.GetBytes(postData)
        request.ContentType = "application/x-www-form-urlencoded"
        request.ContentLength = byteArray.Length
        Dim dataStream As Stream = request.GetRequestStream()

do what you want with the stream

reader.Close()
        dataStream.Close()
        response.Close()
    End Sub
End Class