import tkinter as tk
base=tk.Tk()
button1=tk.Button(base,text="push1",width=15)
button2=tk.Button(base,text="push2",width=15)
button3=tk.Button(base,text="push3",width=15)
button4=tk.Button(base,text="push4",width=15)
button1.grid(row=0,column=0,columnspan=2,ipad=5)
button2.grid(row=1,column=0)
button3.grid(row=1,column=1)
button4.grid(row=2,column=0,columnspan=2,ipad=5)
base.mainloop()