MAOIs, Psychedelics Today

I've seen various people emphasize that RIMAs are safer than irreversibles; that does seem to be true, but the margin of that seems to be exaggerated. It mostly applies to tyramine (the food compound), i.e., RIMAs have a very high tyramine tolerance threshold[ 1 ]…but almost all foods have very low tyramine, so there's practically no difference (more info on this below).
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I've seen some vague information that says that irreversibles are less forgiving with all potentially contraindicated compounds—and it's probably true—but to quote MAOI advocate Ken Gillman, "As Paracelsus stated, ‘the dose makes the poison’ and that certainly applies to amphetamine."[ 2 ]
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𝘛𝘩𝘦𝘳𝘦 𝘪𝘴 𝘯𝘰𝘸 𝘢 𝘭𝘰𝘵 𝘰𝘧 𝘢𝘤𝘤𝘶𝘮𝘶𝘭𝘢𝘵𝘦𝘥 𝘦𝘹𝘱𝘦𝘳𝘪𝘦𝘯𝘤𝘦 𝘰𝘧 𝘵𝘩𝘦 𝘤𝘰𝘯𝘤𝘶𝘳𝘳𝘦𝘯𝘵 𝘢𝘥𝘮𝘪𝘯𝘪𝘴𝘵𝘳𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘔𝘈𝘖𝘐𝘴 𝘢𝘯𝘥 𝘢𝘮𝘱𝘩𝘦𝘵𝘢𝘮𝘪𝘯𝘦 𝘧𝘰𝘳 𝘵𝘩𝘦𝘳𝘢𝘱𝘦𝘶𝘵𝘪𝘤 𝘱𝘶𝘳𝘱𝘰𝘴𝘦𝘴 𝘪𝘯 𝘥𝘦𝘱𝘳𝘦𝘴𝘴𝘪𝘰𝘯. 𝘐𝘵 𝘪𝘴 𝘴𝘢𝘧𝘦 𝘸𝘩𝘦𝘯 𝘥𝘰𝘯𝘦 𝘤𝘢𝘳𝘦𝘧𝘶𝘭𝘭𝘺. 𝘌𝘢𝘳𝘭𝘺 𝘤𝘰𝘯𝘤𝘦𝘳𝘯𝘴 𝘢𝘣𝘰𝘶𝘵 𝘧𝘳𝘦𝘲𝘶𝘦𝘯𝘵 𝘩𝘺𝘱𝘦𝘳𝘵𝘦𝘯𝘴𝘪𝘰𝘯 𝘩𝘢𝘷𝘦 𝘯𝘰𝘵 𝘮𝘢𝘵𝘦𝘳𝘪𝘢𝘭𝘪𝘻𝘦𝘥 𝘢𝘯𝘥 𝘳𝘦𝘤𝘦𝘯𝘵 𝘤𝘭𝘪𝘯𝘪𝘤𝘢𝘭 𝘳𝘦𝘷𝘪𝘦𝘸𝘴 𝘪𝘯𝘥𝘪𝘤𝘢𝘵𝘦 𝘫𝘶𝘥𝘪𝘤𝘪𝘰𝘶𝘴 𝘶𝘴𝘦 𝘪𝘴 𝘴𝘢𝘧𝘦 [ 354, 355 ].[ 3 ]
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"Very few individuals will ingest more than 25 mg of tyramine, even when consuming high-tyramine foods. For patients on MAOIs, ingestion of amounts under 50 mg are unlikely to cause significant blood pressure effects. Even in the early 1960s, when food tyramine was much higher and MAOI users received no dietary guidance, only 14 deaths were reported among an estimated 1.5 million patients who took MAOIs."
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Meyer, J.M. Modern Use of MAOIs. Psychopharmacology Institute, 2019-07-01 (3. Dietary Restriction: What to Tell Patients About Tyramine)
https://psychopharmacologyinstitute.com/publication/modern-use-of-maois-2289
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"if the conclusion is anything other than tyramine and all mess that goes along with it is anything other than Hocus Pocus old science then it's meaningless collectively. I have been [ tranylcypromine ] for like 30 years and long ago I forgot entirely about all that tyramine and preserved sausages and stuff like that, and yet here I am, happy and healthy"
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pumbungler, 2024-06-03, https://old.reddit.com/r/MAOIs/comments/1d69a32/comment/l6va6ti/
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1. Clarification about how MAOIs function and reversibility
https://forum.dmt-nexus.me/threads/372741/
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2. 18. CNS ‘Stimulants’ and MAOIs Part 2. Psychotropical Research. Ken Gillman, MD, 2022, 2023. https://www.psychotropical.com/cns-stim-maoi-part-2/
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3. Monoamine oxidase inhibitors: A review concerning dietary tyramine and drug interactions. Ken Gillman, MD. PsychoTropical Commentaries (2020) 1:1–71 (Releasers (indirectly acting sympatho-mimetics ISAs))
https://psychotropical.com/wp-content/uploads/2020/03/9.2-MAOI_diet_drug_interactions_2020_current_v.pdf
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