("^(?=.*[a-z])(?=.*[A-Z])(?=.*\d)(?=.*[$@$!%*#?&])[A-Za-z\d$@$!%*#?&]{8,50}")

public static void main(String[] args) throws IOException {
    Pattern pat = Pattern.compile("(?=.*[a-z])(?=.*[A-Z])(?=.*\d)(?=.*[$@!%*#?&])[A-Za-z\d$@!%*#?&]{8,50}");
    System.out.println(pat.matcher("#GRDiD1ddddddddd").matches());
    System.out.println(pat.matcher("GRDiD1ddddddddd!#").matches());
    System.out.println(pat.matcher("GRDiD1d#ddddddd!").matches());
    System.out.println(pat.matcher("GRDiD1d#dd#ddddd!").matches());
}

true
true
true
true

(?=.*[a-z])(?=.*[A-Z])(?=.*\d)(?=.*[$@!%*#?&])[A-Za-z\d$@!%*#?&]{8,50}