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define('PHPMAILERHOST', 'smtp.sparkpostmail.com');
$phpmailer_smtpuser = 'SMTP_Injection';
$phpmailer_smtppassword = '<API_KEY>';
define('PHPMAILERPORT', 587);

$config['mailtype'] = "html";
$config['protocol'] = 'smtp';
$config['smtp_host'] = 'smtp.sparkpostmail.com';
$config['smtp_user'] = 'user';
$config['smtp_pass'] = 'password';
$config['smtp_crypto'] = 'tls';
$config['smtp_port'] = '587';
$condig['crlf'] = "rn";
$config['newline'] = "rn";

//Sparkpost configuration
$config['mailtype'] = "html";
$config['protocol'] = 'smtp';
$config['smtp_host'] = 'smtp.sparkpostmail.com';
$config['smtp_user'] = 'user';
$config['smtp_pass'] = 'password';
$config['smtp_crypto'] = 'tls';
$config['smtp_port'] = '587';
$condig['crlf'] = "rn";
$config['newline'] = "rn";

//My email code
$to_email = "$Email";
$from_email = "me@mydomain";
$subject = "Email Subject";
$comment =  "<html>Email message</html>";

// Always set content-type when sending HTML email
$headers = "MIME-Version: 1.0" . "rn";
$headers .= "Content-type:text/html;charset=UTF-8" . "rn";

// More headers
$headers .= "From: Info <" . $from_email . ">rn";
//send email
mail($to_email, "$subject", $comment, $headers);

$mail = new PHPMailer;
$mail->SMTPDebug = 3;
$mail->isSMTP();
$mail->Host = 'smtp.sparkpostmail.com';
$mail->Port = 587;
$mail->SMTPSecure = 'tls';
$mail->SMTPAuth = true;
$mail->Username = 'SMTP_Injection';
$mail->Password = '<API_KEY>'; //make sure you add SMTP permission to API Key
$mail->setFrom('testing@sparkpostbox.com'); //you can use w/o adding your sending domain like ~50 messages. Once you add your sending domain, use that.
$mail->addAddress('recipient@domain.com');
$mail->Subject = 'Test subject';
$mail->Body    = 'Hello World!';
$mail->send();