HKEY_LOCAL_MACHINESystemCurrentControlSetControlSession Manager

??C:Long Directory NameLong File Name.exe

mv %WINDIR%System32mfc42.dll %WINDIRSystem32mfc42.dll.old
Install new mfc42.dll
Tell user to save work and restart applications

using System.Runtime.InteropServices;
using System.Diagnostics;

static public class FileUtil
{
    [StructLayout(LayoutKind.Sequential)]
    struct RM_UNIQUE_PROCESS
    {
        public int dwProcessId;
        public System.Runtime.InteropServices.ComTypes.FILETIME ProcessStartTime;
    }

    const int RmRebootReasonNone = 0;
    const int CCH_RM_MAX_APP_NAME = 255;
    const int CCH_RM_MAX_SVC_NAME = 63;

    enum RM_APP_TYPE
    {
        RmUnknownApp = 0,
        RmMainWindow = 1,
        RmOtherWindow = 2,
        RmService = 3,
        RmExplorer = 4,
        RmConsole = 5,
        RmCritical = 1000
    }

    [StructLayout(LayoutKind.Sequential, CharSet = CharSet.Unicode)]
    struct RM_PROCESS_INFO
    {
        public RM_UNIQUE_PROCESS Process;

        [MarshalAs(UnmanagedType.ByValTStr, SizeConst = CCH_RM_MAX_APP_NAME + 1)]
        public string strAppName;

        [MarshalAs(UnmanagedType.ByValTStr, SizeConst = CCH_RM_MAX_SVC_NAME + 1)]
        public string strServiceShortName;

        public RM_APP_TYPE ApplicationType;
        public uint AppStatus;
        public uint TSSessionId;
        [MarshalAs(UnmanagedType.Bool)]
        public bool bRestartable;
    }

    [DllImport("rstrtmgr.dll", CharSet = CharSet.Unicode)]
    static extern int RmRegisterResources(uint pSessionHandle,
                                          UInt32 nFiles,
                                          string[] rgsFilenames,
                                          UInt32 nApplications,
                                          [In] RM_UNIQUE_PROCESS[] rgApplications,
                                          UInt32 nServices,
                                          string[] rgsServiceNames);

    [DllImport("rstrtmgr.dll", CharSet = CharSet.Auto)]
    static extern int RmStartSession(out uint pSessionHandle, int dwSessionFlags, string strSessionKey);

    [DllImport("rstrtmgr.dll")]
    static extern int RmEndSession(uint pSessionHandle);

    [DllImport("rstrtmgr.dll")]
    static extern int RmGetList(uint dwSessionHandle,
                                out uint pnProcInfoNeeded,
                                ref uint pnProcInfo,
                                [In, Out] RM_PROCESS_INFO[] rgAffectedApps,
                                ref uint lpdwRebootReasons);

    /// <summary>
    /// Find out what process(es) have a lock on the specified file.
    /// </summary>
    /// <param name="path">Path of the file.</param>
    /// <returns>Processes locking the file</returns>
    /// <remarks>See also:
    /// http://msdn.microsoft.com/en-us/library/windows/desktop/aa373661(v=vs.85).aspx
    /// http://wyupdate.googlecode.com/svn-history/r401/trunk/frmFilesInUse.cs (no copyright in code at time of viewing)
    ///
    /// </remarks>
    static public List<Process> WhoIsLocking(string path)
    {
        uint handle;
        string key = Guid.NewGuid().ToString();
        List<Process> processes = new List<Process>();

        int res = RmStartSession(out handle, 0, key);
        if (res != 0) throw new Exception("Could not begin restart session.  Unable to determine file locker.");

        try
        {
            const int ERROR_MORE_DATA = 234;
            uint pnProcInfoNeeded = 0,
                 pnProcInfo = 0,
                 lpdwRebootReasons = RmRebootReasonNone;

            string[] resources = new string[] { path }; // Just checking on one resource.

            res = RmRegisterResources(handle, (uint)resources.Length, resources, 0, null, 0, null);

            if (res != 0) throw new Exception("Could not register resource.");

            //Note: there's a race condition here -- the first call to RmGetList() returns
            //      the total number of process. However, when we call RmGetList() again to get
            //      the actual processes this number may have increased.
            res = RmGetList(handle, out pnProcInfoNeeded, ref pnProcInfo, null, ref lpdwRebootReasons);

            if (res == ERROR_MORE_DATA)
            {
                // Create an array to store the process results
                RM_PROCESS_INFO[] processInfo = new RM_PROCESS_INFO[pnProcInfoNeeded];
                pnProcInfo = pnProcInfoNeeded;

                // Get the list
                res = RmGetList(handle, out pnProcInfoNeeded, ref pnProcInfo, processInfo, ref lpdwRebootReasons);
                if (res == 0)
                {
                    processes = new List<Process>((int)pnProcInfo);

                    // Enumerate all of the results and add them to the
                    // list to be returned
                    for (int i = 0; i < pnProcInfo; i++)
                    {
                        try
                        {
                            processes.Add(Process.GetProcessById(processInfo[i].Process.dwProcessId));
                        }
                        // catch the error -- in case the process is no longer running
                        catch (ArgumentException) { }
                    }
                }
                else throw new Exception("Could not list processes locking resource.");
            }
            else if (res != 0) throw new Exception("Could not list processes locking resource. Failed to get size of result.");
        }
        finally
        {
            RmEndSession(handle);
        }

        return processes;
    }
}

string[] files = Directory.GetFiles(target_dir);
    List<Process> lstProcs = new List<Process>();

    foreach (string file in files)
    {
        lstProcs = ProcessHandler.WhoIsLocking(file);
        if (lstProcs.Count > 0) // deal with the file lock
        {
            foreach (Process p in lstProcs)
            {
                if (p.MachineName == ".")
                    ProcessHandler.localProcessKill(p.ProcessName);
                else
                    ProcessHandler.remoteProcessKill(p.MachineName, txtUserName.Text, txtPassword.Password, p.ProcessName);
            }
            File.Delete(file);
        }
        else
            File.Delete(file);
    }

public static void localProcessKill(string processName)
{
    foreach (Process p in Process.GetProcessesByName(processName))
    {
        p.Kill();
    }
}

public static void remoteProcessKill(string computerName, string fullUserName, string pword, string processName)
{
    var connectoptions = new ConnectionOptions();
    connectoptions.Username = fullUserName;  // @"YourDomainNameUserName";
    connectoptions.Password = pword;

    ManagementScope scope = new ManagementScope(@"\" + computerName + @"rootcimv2", connectoptions);

    // WMI query
    var query = new SelectQuery("select * from Win32_process where name = '" + processName + "'");

    using (var searcher = new ManagementObjectSearcher(scope, query))
    {
        foreach (ManagementObject process in searcher.Get())
        {
            process.InvokeMethod("Terminate", null);
            process.Dispose();
        }
    }
}