$ ls TestPrograms/
dump2def.cxx         test_arm_sm4.cxx      test_x86_avx.cxx
test_32bit.cxx       test_cxx.cxx          test_x86_avx2.cxx
test_64bit.cxx       test_mixed_asm.cxx    test_x86_avx512.cxx
...

$ cat test_cxx.cxx
#include <string>
int main(int argc, char* argv[])
{
    unsigned int x=0;
    return x;
}

CXXFLAGS="-msse2"
AC_MSG_CHECKING([if $CXXNAME supports $CXXFLAGS and Foo Bar])
AC_LINK_IFELSE(
   [AC_LANG_PROGRAM([TestPrograms/test_x86_sse2.cxx])],
   [AC_MSG_RESULT([yes])],
   [AC_MSG_RESULT([no])]
)

checking if g++ supports -msse2 and Foo Bar... no

CXXFLAGS="-msse2"
AC_MSG_CHECKING([if $CXXNAME supports $CXXFLAGS and Foo Bar])
AC_LINK_IFELSE(
   [AC_LANG_PROGRAM(`cat TestPrograms/test_x86_sse2.cxx`)],
   [AC_MSG_RESULT([yes])],
   [AC_MSG_RESULT([no])]
)

$ g++ -msse2 TestPrograms/test_x86_sse2.cxx
$