...
if  (request.method == 'POST'):
    if request.FILES.has_key('file'):
        file = request.FILES['file']
        with open(settings.destfolder+'/%s' % file.name, 'wb+') as dest:
            for chunk in file.chunks():
                dest.write(chunk)

c = Client()
with open('wishlist.doc') as fp:
  c.post('/customers/wishes/', {'name': 'fred', 'attachment': fp})

from django.core.files.uploadedfile import SimpleUploadedFile

def test_upload_video(self):
    video = SimpleUploadedFile("file.mp4", "file_content", content_type="video/mp4")
    self.client.post(reverse('app:some_view'), {'video': video})
    # some important assertions ...

def upload_file_to_location(request, location=None): # Can use the default configured

import tempfile, csv, os

class UploadPaperTest(TestCase):

    def generate_file(self):
        try:
            myfile = open('test.csv', 'wb')
            wr = csv.writer(myfile)
            wr.writerow(('Paper ID','Paper Title', 'Authors'))
            wr.writerow(('1','Title1', 'Author1'))
            wr.writerow(('2','Title2', 'Author2'))
            wr.writerow(('3','Title3', 'Author3'))
        finally:
            myfile.close()

        return myfile

    def setUp(self):
        self.user = create_fuser()
        self.profile = ProfileFactory(user=self.user)
        self.event = EventFactory()
        self.client = Client()
        self.module = ModuleFactory()
        self.event_module = EventModule.objects.get_or_create(event=self.event,
                module=self.module)[0]
        add_to_admin(self.event, self.user)

    def test_paper_upload(self):
        response = self.client.login(username=self.user.email, password='foz')
        self.assertTrue(response)

        myfile = self.generate_file()
        file_path = myfile.name
        f = open(file_path, "r")

        url = reverse('registration_upload_papers', args=[self.event.slug])

        # post wrong data type
        post_data = {'uploaded_file': i}
        response = self.client.post(url, post_data)
        self.assertContains(response, 'File type is not supported.')

        post_data['uploaded_file'] = f
        response = self.client.post(url, post_data)

        import_file = SubmissionImportFile.objects.all()[0]
        self.assertEqual(SubmissionImportFile.objects.all().count(), 1)
        #self.assertEqual(import_file.uploaded_file.name, 'files/registration/{0}'.format(file_path))

        os.remove(myfile.name)
        file_path = import_file.uploaded_file.path
        os.remove(file_path)

TypeError: sequence item 4: expected bytes, bytearray, or an object with the buffer interface, str found