$ hyperfine --warmup 1 -i "vpython3 ~/git/depot_tools/autoninja.py -help" "python3 ~/git/depot_tools/autoninja.py -help"
Benchmark 1: vpython3 ~/git/depot_tools/autoninja.py -help
  Time (mean ± σ):     386.2 ms ±   5.4 ms    [User: 179.7 ms, System: 56.5 ms]
  Range (min … max):   380.1 ms … 397.4 ms    10 runs

  Warning: Ignoring non-zero exit code.

Benchmark 2: python3 ~/git/depot_tools/autoninja.py -help
  Time (mean ± σ):     280.1 ms ±  43.3 ms    [User: 192.6 ms, System: 62.6 ms]
  Range (min … max):   238.9 ms … 375.3 ms    12 runs

  Warning: Ignoring non-zero exit code.

Summary
  python3 ~/git/depot_tools/autoninja.py -help ran
    1.38 ± 0.21 times faster than vpython3 ~/git/depot_tools/autoninja.py -help