Friction or repeated rubbing causes corns and calluses - thick, hardened dead skin - on the feet and toes. Painful calluses can form at the bottom of foot that typically bears most of the pressure and friction from walking and standing. To relieve corns, a moleskin pad is very helpful; while trimming and surgery for serious cases is preferred to correct foot calluses and foot pain in the bottom of foot.

The foot, ankle, or knee can also suffer from gout, which is usually caused by a high amount of uric acid (UA) in the body, and which results in hard crystals being formed outside the joints, leading to foot pain in the bottom of foot. Patients can suffer from attacks that last for days or even weeks, and normal treatment is with anti-inflammatory or UA-lowering medication. For gout prevention, it is best to eat a low-cholesterol, low-fat diet; avoid high-purine foods and fructose; slowly lose weight; restrict intake of alcohol; and stay hydrated.


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